Establishing a malaria diagnostics centre of excellence in Kisumu, Kenya

Ohrt, Colin; Obare, Peter; Na-Nakorn, Ampon; Adhiambo, Christine; Awuondo, Ken; O’Meara, Wendy Prudhomme; Remich, Shon; Martin, Kurt; Cook, Earnest; Chrétien, Dominique; Lucas, Carmen; Osoga, Joseph; McEvoy, Peter; Owaga, M. L.; Odera, James Sande; Ogutu, Bernhards

doi:10.1186/1475-2875-6-79

Cited by 64 publications

(63 citation statements)

References 17 publications

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“…15 Although there is value in maintaining microscopic skills, the variability in technical capacity introduces a serious concern regarding diagnostic accuracy that has been reduced with the use of RDTs in other settings. [16][17][18][19] On the other hand, there are benefits of maintaining microscopy skills and not depending solely on RDTs. With microscopy, parasite density can be quantified.…”

Section: Discussionmentioning

confidence: 99%

The Role of Laboratory Supervision in Improving the Quality of Malaria Diagnosis: A Pilot Study in Huambo, Angola

Luckett

Mugizi

Lopes

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. In 2006, the Angolan National Malaria Control Program introduced clinical guidelines for malaria case management, which included diagnostic confirmation of malaria before administration of treatment; however, diagnostic practices were inconsistent and of unknown quality. In 2009, a laboratory supervision program was implemented in Huambo Province, with the goal of assessing and improving diagnosis of malaria within the confines of available in-country resources. Supervisions were carried out from 2009 to 2014 using a standardized supervision tool by national laboratory trainers. Data from the first supervision were compared with that from the final supervision. Over the study period, the number and level of training of laboratory technicians increased, and there was a nonstatistically significant trend toward improved laboratory conditions. There was a significant reduction in false-positive microscopy slide reading (P = 0.0133). Laboratory infrastructural capacity to diagnose other communicable diseases, including syphilis, human immunodeficiency virus and hepatitis B virus infections (P = 0.0012, 0.0233 and 0.0026, respectively), also improved significantly. Laboratory supervision for malaria diagnosis found significant areas for improvement, and in combination with concurrent capacitybuilding activities, it improved the diagnostic capacity for malaria and other diseases. Importantly, this study demonstrates that locally available resources can be used to improve the accuracy of malaria diagnosis.

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Section: Discussionmentioning

confidence: 99%

The Role of Laboratory Supervision in Improving the Quality of Malaria Diagnosis: A Pilot Study in Huambo, Angola

Luckett

Mugizi

Lopes

et al. 2016

The American Society of Tropical Medicine and Hygiene

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“…This training has been shown to improve sensitivity and specificity of microscopic diagnosis of malaria to 85% and 90%, respectively. 6 The two expert study microscopists also attended the 2-week Malaria Microscopy Training Course. They both hold degrees in medical laboratory science.…”

Section: Methodsmentioning

confidence: 99%

High Sensitivity and Specificity of Clinical Microscopy in Rural Health Facilities in Western Kenya Under an External Quality Assurance Program

Wafula

Sang

Cheruiyot

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Microscopic diagnosis of malaria is a well-established and inexpensive technique that has the potential to provide accurate diagnosis of malaria infection. However, it requires both training and experience. Although it is considered the gold standard in research settings, the sensitivity and specificity of routine microscopy for clinical care in the primary care setting has been reported to be unacceptably low. We established a monthly external quality assurance program to monitor the performance of clinical microscopy in 17 rural health centers in western Kenya. The average sensitivity over the 12-month period was 96% and the average specificity was 88%. We identified specific contextual factors that contributed to inadequate performance. Maintaining high-quality malaria diagnosis in high-volume, resource-constrained health facilities is possible. BACKGROUND

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“…21 DoD-GEIS scientists in Asia, East Africa, and South America have documented the continued spread of markers suggesting the potential for malaria drug resistance emergencenotably recent artesunate-class drug resistance-while working to standardize laboratory methodology and microscopy. [22][23][24][25][26][27][28][29][30] A collaboration between the National Aeronautics and Space Administration, USAMRU-K, and DoD-GEIS headquarters has developed an effective, satellite-based early warning tool for rift valley fever in East Africa and is now working to expand its applicability to other climate-dependent epidemic diseases. [31][32][33][34][35][36] The network has also overseen the development and refinement of a series of systems designed to bring real-time disease surveillance to remote or low-resource settings, including Cambodia, Laos, Thailand, the Philippines, and Andean Ridge countries of South America.…”

Section: Discussionmentioning

confidence: 99%

Global Infectious Disease Surveillance at DoD Overseas Laboratories, 1999–2007

Sueker

Chrétien²,

Gaydos³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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Abstract. The United States Department of Defense Global Emerging Infections Surveillance and Response System (DoD-GEIS) conducted a review in 2008 of projects funded by DoD-GEIS at five partner overseas laboratories from 1999 through 2007. During this period, the annual overseas programming budget grew from US$1.038 million to US$21 million. The review describes the distribution of project priorities and geographic locations over the years, the types of outcomes the projects generated, and the frequency with which they involved collaboration with other public health agencies and organizations, including CDC and WHO. Areas for further program strengthening are identified.

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Establishing a malaria diagnostics centre of excellence in Kisumu, Kenya

Cited by 64 publications

References 17 publications

The Role of Laboratory Supervision in Improving the Quality of Malaria Diagnosis: A Pilot Study in Huambo, Angola

The Role of Laboratory Supervision in Improving the Quality of Malaria Diagnosis: A Pilot Study in Huambo, Angola

High Sensitivity and Specificity of Clinical Microscopy in Rural Health Facilities in Western Kenya Under an External Quality Assurance Program

Global Infectious Disease Surveillance at DoD Overseas Laboratories, 1999–2007

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