Establishing an alternative method for the quantitative analysis of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans by comprehensive two dimensional gas chromatography–time-of-flight mass spectrometry for developing countries

Vos, Jayne De; Gorst-Allman, Peter; Rohwer, Egmont Richard

doi:10.1016/j.chroma.2011.03.050

Cited by 19 publications

(9 citation statements)

References 18 publications

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“…Linear regression analyses were performed after blank correction, using the Data Analysis Toolkit in Excel. The limit of detection (LOD) of each target compound was calculated as three times the signal to noise (S/N) ratio and the limit of quantitation (LOQ) as ten times the S/N ratio [23]. The use of matrix matched standards for calibration purposes was necessary in order to correct for any reduced recoveries for heavier PAHs.…”

Section: Matrix Matched Calibration Standardsmentioning

confidence: 99%

Monitoring of atmospheric gaseous and particulate polycyclic aromatic hydrocarbons in South African platinum mines utilising portable denuder sampling with analysis by thermal desorption–comprehensive gas chromatography–mass spectrometry

Geldenhuys

Rohwer

Naude

et al. 2015

Journal of Chromatography A

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Concentrations of diesel particulate matter and polycyclic aromatic hydrocarbons (PAHs) in platinum mine environments are likely to be higher than in ambient air due to the use of diesel machinery in confined environments. Airborne PAHs may be present in gaseous or particle phases each of which has different human health impacts due to their ultimate fate in the body. Here we report on the simultaneous sampling of both phases of airborne PAHs for the first time in underground platinum mines in South Africa, which was made possible by employing small, portable denuder sampling devices consisting of two polydimethylsiloxane (PDMS) multichannel traps connected in series separated by a quartz fibre filter, which only require small, battery operated portable personal sampling pumps for air sampling. Thermal desorption coupled with comprehensive gas chromatography -mass spectrometry (TD-GCxGC-TofMS) was used to analyse denuder samples taken in three different platinum mines. The samples from a range of underground environments revealed that PAHs were predominantly found in the gas phase with naphthalene and mono-methylated naphthalene derivatives being detected at the highest concentrations ranging from 0.01 to 18 g m -3 . The particle bound PAHs were found in the highest concentrations at the idling load haul dump vehicle exhausts with a dominance of fluoranthene and pyrene. Particle associated PAH concentrations ranged from 0.47 to 260 ng m -3 and included benzo[k]fluoranthene, benzo[a]pyrene, indeno[1,2,3-cd]pyrene and benzo [ghi]perylene. This work highlights the need to characterise both phases in order to assess occupational exposure to PAHs in this challenging sampling environment.

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Section: Matrix Matched Calibration Standardsmentioning

confidence: 99%

Monitoring of atmospheric gaseous and particulate polycyclic aromatic hydrocarbons in South African platinum mines utilising portable denuder sampling with analysis by thermal desorption–comprehensive gas chromatography–mass spectrometry

Geldenhuys

Rohwer

Naude

et al. 2015

Journal of Chromatography A

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“…De Vos et al (de Vos et al, 2011a) developed an alternative method of GC coupled with High Resolution Mass Spectrometry (HRMS) for analysis of PCDDs and PCDFs using GC×GC-TOFMS in different matrices. Three GC column combinations (Rtx-Dioxin 2Rtx-PCB, Rxi-5 SilMSRtx-200 and Rxi-XLBRtx-200) were evaluated to quantify PCDDs and PCDFs in numerous soil and sediment samples taken from various strategic sites in South Africa with a highest result obtained of 76 ng Toxic Equivalent Quantity/kg.…”

Section: Pcdds and Pcdfsmentioning

confidence: 99%

Recent Applications of Comprehensive Two-Dimensional Gas Chromatography to Environmental Matrices

Cardinaël¹,

Auguste²,

Peulon-Agasse³

2012

Advanced Gas Chromatography - Progress in Agricultural, Biomedical and Industrial Applications

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“…1,2,14 Comprehensive two-dimensional gas chromatography with time of flight mass spectrometry (GC × GC-TOFMS) has demonstrated remarkable results in several fields of analytical chemistry. [15][16][17] Nevertheless, in contrast with areas such as environmental [18][19][20][21] and petroleum chemistry, 20,22,23 few works describe the application of the GC × GC-TOFMS system in doping analysis. It was already demonstrated the higher sensitivity of the system with the preservation of the full spectral information relative to the detection of methyltestosterone metabolites, clenbuterol, epimetendiol and 3'OH-stanozolol at 2 ng/ mL.…”

Section: Introductionmentioning

confidence: 99%

Specificity and selectivity improvement in doping analysis using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry

Barbosa¹,

Leal²,

Padilha³

et al. 2012

Quím. Nova

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Recebido em 5/9/11; aceito em 21/11/11; publicado na web em 31/1/12Comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry was used for the identification of forty doping agents. The improvement in the specificity was remarkable, allowing the resolution of analytes that could not be done by one-dimensional chromatographic systems. The sensitivity observed for different classes of prohibited substances was clearly below the value required by the World Anti-Doping Agency. In addition time-of-flight mass spectrometry gives full spectrum for all analytes without any interference from the matrix, resulting in selectivity improvements. These results could support the implementation of an exhaustive monitoring approach for hundreds of doping agents in a single injection.

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Establishing an alternative method for the quantitative analysis of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans by comprehensive two dimensional gas chromatography–time-of-flight mass spectrometry for developing countries

Cited by 19 publications

References 18 publications

Monitoring of atmospheric gaseous and particulate polycyclic aromatic hydrocarbons in South African platinum mines utilising portable denuder sampling with analysis by thermal desorption–comprehensive gas chromatography–mass spectrometry

Monitoring of atmospheric gaseous and particulate polycyclic aromatic hydrocarbons in South African platinum mines utilising portable denuder sampling with analysis by thermal desorption–comprehensive gas chromatography–mass spectrometry

Recent Applications of Comprehensive Two-Dimensional Gas Chromatography to Environmental Matrices

Specificity and selectivity improvement in doping analysis using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry

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