Establishing an antigen‐negative red blood cell inventory in a hospital‐based blood bank

Le, Nguyet; Harach, Mary; Kay, Julie K.; Brown, Rosemary P.; Everetts, Jovanna N.; Herman, Jay H.

doi:10.1111/trf.12270

Cited by 8 publications

(7 citation statements)

References 4 publications

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“…Costs in the model were approximated from average costs at CUMC charged for each patient for various procedures, blood products and laboratory tests. The CUMC costs also closely approximated the reimbursement costs published by Centers for Medicare and Medicaid as well as the ones reported from another centre in the north‐eastern US . Only direct costs were included in the model (Table b).…”

Section: Methodsmentioning

confidence: 80%

Phenotypically matched vs. traditional screen method for preparing red blood cell units in patients with abnormal placentation: a decision analysis approach

2014

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Section: Methodsmentioning

confidence: 80%

Phenotypically matched vs. traditional screen method for preparing red blood cell units in patients with abnormal placentation: a decision analysis approach

2014

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“…The same study showed that establishing institutional inventory of antigen negative units significantly reduced cost as compared to obtaining antigen negative units from outside suppliers, a practice that can be adopted by large transfusion centers [13].…”

Section: Discussionmentioning

confidence: 93%

Lifetime risk and characterization of red blood cell alloimmunization in chronically transfused patients with sickle cell disease

Woldie

Swerdlow²,

M.H.³

et al. 2015

Int J Blood Transfus Immunohematol

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“…1–4 In the setting of stem cell therapy, delayed red cell engraftment complications due to alloimmunization can be obviated. 5–7 This prophylactic matching can be accomplished by serologic testing 8,9 or by red cell genotype ‘dry’ matching. 10 …”

Section: Introductionmentioning

confidence: 99%

Integration of red cell genotyping into the blood supply chain: a population-based study

Flegel

Gottschall

Denomme

2015

The Lancet Haematology

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Background When problems with compatibility arise, transfusion services often perform time-consuming serologic testing to locate antigen-negative red cell units for safe transfusion. New technologies enabled red cell genotyping for all clinically relevant blood group antigens. We performed mass-scale genotyping and provided access to a large red cell database to meet the demand for antigen-negative red cell units beyond ABO and Rh. Methods A red cell genotype database was established in 2010. Hospitals were given online access to a web-based antigen query portal in 2013 to find antigen-negative units in their inventories. Findings Genotype data were analyzed for 43,066 blood donors covering a set of 42 clinically relevant red cell antigens. Requests were filled for 5661 of 5672 patient encounters (99.8%) requiring antigen-negative red cell units in a multi-ethnic and multi-racial population. Red cell genotyping met the demand for antigen-negative blood in 5339 of 5672 (95%) patient encounters, while 333 remaining requests were filled using serologic data. In a pilot phase, seven community and rural transfusion services searched their local inventories using an online antigen query portal. Interpretation Red cell genotyping has the potential to transform the way antigen-negative red cell units are provided. An antigen query portal may reduce the need to ship blood or perform serologic screening. The wealth of genotype data, easily accessible online, facilitates the supply of affordable antigen-negative red cell units for patient safety. Physicians may recognize these new efficiencies for patient transfusion support. Funding BloodCenter of Wisconsin Diagnostic Laboratories Strategic Initiative and the NIH Clinical Center Intramural Research Program.

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Establishing an antigen‐negative red blood cell inventory in a hospital‐based blood bank

Abstract: Establishing an AG- inventory in a hospital-based blood bank is cost-effective and time-efficient.

Cited by 8 publications

References 4 publications

Phenotypically matched vs. traditional screen method for preparing red blood cell units in patients with abnormal placentation: a decision analysis approach

Phenotypically matched vs. traditional screen method for preparing red blood cell units in patients with abnormal placentation: a decision analysis approach

Lifetime risk and characterization of red blood cell alloimmunization in chronically transfused patients with sickle cell disease

Integration of red cell genotyping into the blood supply chain: a population-based study

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