Establishing biological reference intervals for novel platelet parameters (immature platelet fraction, high immature platelet fraction, platelet distribution width, platelet large cell ratio, platelet-X, plateletcrit, and platelet distribution width) and their correlations among each other

Sachdev, Ritesh; Tiwari, Aseem Kumar; Goel, Shalini; Raina, Vimarsh; Sethi, Monisha

doi:10.4103/0377-4929.134676

Cited by 60 publications

(40 citation statements)

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“…In contrast with previous studies, we reported an inverse association between p-LCR and acute presentation [37], while we confirmed the well-established relationship between platelets count and size [38], thus suggesting that p-LCR could represent a Breactive^condition of increased consumption of circulating platelets, with the release in the bloodstream of larger, immature fractions, of platelets. In fact, higher levels of thrombopoietin, a key hormone in thrombopoietic signalling, have been related to platelet size in CAD patients [39,40].…”

Section: Discussionsupporting

confidence: 57%

Platelet Larger Cell Ratio and High-on Treatment Platelet Reactivity During Dual Antiplatelet Therapy

Verdoia

Pergolini

Rolla

et al. 2015

Cardiovasc Drugs Ther

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Section: Discussionsupporting

confidence: 57%

Platelet Larger Cell Ratio and High-on Treatment Platelet Reactivity During Dual Antiplatelet Therapy

Verdoia

Pergolini

Rolla

et al. 2015

Cardiovasc Drugs Ther

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“…[4,5]. As different autoanalyzer can have different values, making it difficult to compare between studies, necessitating each study define its mean [27][28][29][30]. In Dengue illness an MPV of less than nine has been suggested to have a diagnostic potential with a high reported sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Rising Mean Platelet Volume (MPV) Heralding Platelets Recovery in Dengue?

Khandal¹,

Raghuraman²

2017

AJCMR

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Infectious diseases including Dengue illness remains the commonest cause of hospitalization in Indian settings. It is a significant global public health problem, with 2.5 billion world's population at risk and an estimated 50 to 390 million annual infections. Clinically, dengue illness manifestation varies from asymptomatic state to severe symptomatic disease. Symptomatic disease events in turn range from self-limiting dengue fever (DF) to severe dengue. Severe dengue, manifests as; dengue hemorrhagic fever (DHF), hypovolemic shock-dengue shock syndrome (DSS) or severe organ impairment. Thrombocytopenia is a common element to both dengue fever and severe dengue; and clinicians, unfortunately, tend to 'react' to thrombocytopenia with platelet transfusions at predetermined platelet thresholds. Readily available lab parameters to guide the clinician of impending platelet recovery is needed, one such parameter gaining recent interest is Platelet Indices (PIs): mean platelet volume (MPV) and platelet distribution width (PDW). Serially observing mean platelet volume along with Platelets might be valuable, with a rising trend in MPV suggesting platelet and patient recovery.

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“…5 The normal range for MPV in Indian population is from 8.6-15.5 fL. 6 PDW is a marker of volume variability in platelets size and is elevated in the presence of platelet anisocytosis. 7 The PDW reported varies with reference intervals ranging from 8.3 to 56.6%.…”

Section: Platelet Indicesmentioning

confidence: 99%

Platelet indices evaluation in patients with dengue fever

Mukker

Kiran

2018

Int J Res Med Sci

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Background: Platelet indices (PIs)-Platecrit, mean platelet volume (MPV) and platelet distribution width (PDW)-are a group of platelet parameters obtained as a part of complete blood count using automated hematology analyzers. Evidence suggests that PIs may have diagnostic and prognostic value in febrile thrombocytopenia. This study aims to understand the profile of PIs in dengue fever. Aims and objectives was to study the platelet indices in patients with dengue fever.Methods: The present study is a retrospective observational study conducted in a tertiary hospital in Kerala. Platelet count, mean platelet volume (MPV), platecrit and Platelet distribution width (PDW) along with routine blood parameters hemoglobin(Hb), hematocrit, WBC, Platelet count, serum bilirubin, liver enzymes (AST, ALT) of 123 patients were collected. These 123 patients were grouped into three according to the platelet count (<20000,20000-100000, >100000). All the test results are available in hospital database. This was accessed using inpatient numbers obtained from medical records department of our institution. All analysis was done using free to use software R and values were rounded off to the nearest decimal point. Non normally distributed parameters were expressed as median (IQR). Parameters which did not follow normal distribution were analyzed with Kruskall Wallis test and the values are expressed as mean (SD) and a p value <0.05 was considered statistically significant.Results: Platelet indices PDW (57±13.8 vs. 55.4±6.9, p value 0.001) and MPV (9.2±0.09 vs. 13.8±1.3fL, p value <0.001) values were significantly altered in dengue fever with platelet counts below 20,000 compared to platelet count more than one lakh group. Similarly, the Platelet index (MPVxPDW\PLCxPCT), MPV\PLC, MPV\Platecrit, PDW\PLC and PDW\Platecrit ratio showed statistically significant difference between the different platelet groups.Conclusions: Platelet indices are useful parameters in dengue infection. Other than platelet count, PDW, MPV, platecrit are useful to monitor dengue fever.

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Establishing biological reference intervals for novel platelet parameters (immature platelet fraction, high immature platelet fraction, platelet distribution width, platelet large cell ratio, platelet-X, plateletcrit, and platelet distribution width) and their correlations among each other

Abstract: These novel platelet parameters offer newer avenues in research and clinical use. Establishing biological reference interval for different platelet parameters would help determine true high and low values and help guide treatment decisions.

Cited by 60 publications

References 0 publications

Platelet Larger Cell Ratio and High-on Treatment Platelet Reactivity During Dual Antiplatelet Therapy

Platelet Larger Cell Ratio and High-on Treatment Platelet Reactivity During Dual Antiplatelet Therapy

Rising Mean Platelet Volume (MPV) Heralding Platelets Recovery in Dengue?

Platelet indices evaluation in patients with dengue fever

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