Establishing the minimal clinically important difference for the Questionnaire of Olfactory Disorders

Mattos, José L.; Schlosser, Rodney J.; Mace, Jess C.; Smith, Timothy L.; Soler, Zachary M.

doi:10.1002/alr.22135

Cited by 50 publications

(69 citation statements)

References 20 publications

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“…Next, inflation may have altered the current values in the Thompson and Hickey classification. Additionally, loss to postoperative study follow‐up may introduce some measure of relative selection bias, although the percentage of follow‐up loss (∼21%) in this investigation is similar to that of other patient cohorts electing ESS in a tertiary referral environment …”

Section: Discussionmentioning

confidence: 61%

Socioeconomic factors impact quality of life outcomes and olfactory measures in chronic rhinosinusitis

Beswick¹,

Mace

Rudmik

et al. 2018

Int Forum Allergy Rhinol

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Background Healthcare disparities related to socioeconomic factors may adversely impact disease states and treatment outcomes. Among patients with chronic rhinosinusitis (CRS), the impact of socioeconomic factors on outcomes following endoscopic sinus surgery (ESS) remains uncertain. Methods Adult patients with refractory CRS were prospectively enrolled into an observational, multi‐institutional cohort study between March 2011 and June 2015. Socioeconomic factors analyzed included household income, insurance status, years of education completed, race, age, and ethnicity. Income was stratified according to the Thompson and Hickey model. The 22‐item Sino‐Nasal Outcome Test (SNOT‐22) and Brief Smell Identification Test (BSIT) were completed preoperatively and postoperatively. Results A total of 392 patients met inclusion criteria. Higher age and male gender were associated with better mean preoperative SNOT‐22 scores (both p < 0.02), whereas Medicare insurance status and male gender were associated with worse preoperative mean BSIT scores (both p < 0.02). Postoperatively, higher household income ($100,001+/year) and lower age were associated with a greater likelihood of improving at least 1 minimal clinically important difference (MCID) on SNOT‐22 scores (OR = 2.40 and 1.03, respectively, both p < 0.05), while no factors were associated with increased odds of achieving a MCID on BSIT scores. Conclusions Preoperative olfactory function and postoperative quality of life (QOL) improvement were associated with metrics of socioeconomic status in patients with CRS electing ESS. The odds of experiencing a clinically meaningful QOL improvement were more than twice as likely for patients with the highest household income level compared to other income tiers. Further investigation is warranted to identify barriers to postoperative improvement.

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Section: Discussionmentioning

confidence: 61%

Socioeconomic factors impact quality of life outcomes and olfactory measures in chronic rhinosinusitis

Beswick¹,

Mace

Rudmik

et al. 2018

Int Forum Allergy Rhinol

Self Cite

View full text Add to dashboard Cite

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“…Mattos et al showed that olfactoryspecific questionnaires can be helpful for post-treatment follow-up, they also established the minimal clinically important difference of these questionnaires which helps to gauge clinically relevant differences in olfactory function, and the impact of interventions. 20 However, Philpott et al reported that only 28% patients in a rhinology clinic are aware of their olfactory function before being tested. 21 A survey at the clinic conducted by Lötsch et al have shown that almost 30% (355/1227) of anosmic subjects rated their ability to smell as at least "average".…”

Section: Assessment Of Olfactory Function 21 | Subjective Assessmentmentioning

confidence: 99%

“…Therefore, “subjective” olfactory assessment appears to be helpful for olfaction screening when psychophysical tests are unavailable. Mattos et al showed that olfactory‐specific questionnaires can be helpful for post‐treatment follow‐up, they also established the minimal clinically important difference of these questionnaires which helps to gauge clinically relevant differences in olfactory function, and the impact of interventions 20 . However, Philpott et al reported that only 28% patients in a rhinology clinic are aware of their olfactory function before being tested 21 .…”

Section: Assessment Of Olfactory Functionmentioning

confidence: 99%

Olfaction: Sensitive indicator of inflammatory burden in chronic rhinosinusitis

Xing

Whitcroft

Hummel

2020

Laryngoscope Investig Oto

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Background and Objective: Olfactory dysfunction has a high prevalence in chronic rhinosinusitis (CRS) patients and significantly affects quality of life. CRS is recognized as a complex disorder encompassing heterogeneous inflammatory processes in the nose and paranasal sinuses. Olfactory dysfunction in CRS patients is associated with the level of inflammatory mediators and the efficiency of inflammatory control. Learning about the association between CRS-related inflammation and olfactory function will provide clues to the pathogenesis of CRS. Structure: The first section of this review describes the assessment of olfactory function using various measures, from ratings to MR based imaging. Then, we discuss the conductive and inflammatory mechanisms related to olfactory dysfunction in CRS: olfaction is associated with certain inflammatory patterns and is potentially a marker of CRS subtype. Finally, we review anti-inflammatory therapies including conservative and surgical approaches, and their effectiveness in olfactory dysfunction in CRS. Conclusion: Assessment of olfactory function should be considered in the clinical evaluation of CRS patients, not only for detecting and quantifying patients' symptom, but also because it appears to be useful to objectively assess the efficacy of CRS treatment over time. In addition, olfaction can be expected to expand the library of CRS phenotypes and endotypes and, hence, pave the way for more precise, tailored treatment options.

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“…Two studies used the QOD-NS to report the postoperative olfactory changes in non-classified CRS patients. 35,37 There was obvious evidence of heterogeneity between the trials and thus, a random-effects model was used. Quantitative analysis identified 239 patients with non-classified CRS, with an improvement of −6.57 per item in the weighted mean difference (95% CI: −10.30 to − 2.84, P = .001) ( Figure S3).…”

Section: The Qod-ns and Olfactory Changesmentioning

confidence: 99%

Olfactory changes after endoscopic sinus surgery for chronic rhinosinusitis: A meta‐analysis

Zhao

Chen

Tang

2020

Clinical Otolaryngology

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Establishing the minimal clinically important difference for the Questionnaire of Olfactory Disorders

Abstract: Distribution-based MCID values of the QOD-NS range between 2.6 and 8.6 points, with an average of 5.2. When stratified by preoperative QOD-NS scores the majority of patients reporting abnormal preoperative QOD-NS scores achieved a MCID.

Cited by 50 publications

References 20 publications

Socioeconomic factors impact quality of life outcomes and olfactory measures in chronic rhinosinusitis

Socioeconomic factors impact quality of life outcomes and olfactory measures in chronic rhinosinusitis

Olfaction: Sensitive indicator of inflammatory burden in chronic rhinosinusitis

Olfactory changes after endoscopic sinus surgery for chronic rhinosinusitis: A meta‐analysis

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