Establishment and analysis of in vitro biomass from Salvia corrugata Vahl. and evaluation of antimicrobial activity

Bisio, Angela; Fraternale, Daniele; Schito, Anna Maria; Parricchi, Anita; Piaz, Fabrizio Dal; Ricci, Donata; Ruffoni, B.; Tommasi, Nunziatina De

doi:10.1016/j.phytochem.2015.12.017

Cited by 20 publications

(20 citation statements)

References 53 publications

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“…Once the complete assignment of the NMR data of conacytone is at hand, and thanks to a reviewer observation, it follows that the data agree with those of an oily molecule named turbinatone, which was isolated from Eupatorium turbinatum , to which structure 3 was assigned independently. In addition, 3 was also detected recently in Salvia corrugata .…”

Section: Resultsmentioning

confidence: 67%

Absolute configuration of the diterpenoids icetexone and conacytone from Salvia ballotaeflora

et al. 2017

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Detailed literature inspections regarding the diterpenoids icetexone (1) and conacytone (3) reveal that the absolute configuration (AC) of these natural occurring compounds is not rigorously proven, despite they were originally isolated in 1976. This task is now completed by single-crystal X-ray diffraction Flack and Hooft parameters determination after processing data collected with Cu Kα graphite monochromated radiation. The AC of both compounds is further determined by vibrational circular dichroism measurements performed on icetexone acetate (2) and conacytone triacetate (4) since the solubility of 1 and 3 is limited. Comparison of the substituent chemical shifts (SCS) induced by acetylation of 1 and 3 to afford 2 and 4, respectively, reveals that in the case of icetexone, all six SCS values of the quinone ring are in excellent agreement with the expected values, while in the case of conacytone, three agree and three do not agree due to the presence of additional acetates near the quinone ring. Density functional theory calculations performed on 3-hydroxythymoquinone (6) and its tautomer 4-hydroxy-1,2-quinone 7, on 6-hydroxythymoquinone (8) and its tautomer ortho-quinone 9, and on icetexone (1) and the claimed natural occurring ortho-quinone tautomer romulogarzone (5) indicate that 2-hydroxy-1,4-quinones are more stable, by some 11-14 kcal/mol, than their 4-hydroxy-1,2-quinone tautomers, and therefore, romulogarzone (5) is inexistent.

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Section: Resultsmentioning

confidence: 67%

Absolute configuration of the diterpenoids icetexone and conacytone from Salvia ballotaeflora

et al. 2017

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“…However, many studies performed with the diterpenes did not evaluate the effects of these compounds on normal human cells, which is essential to determine a potential use in cancer therapy. and vancomycin resistant Enterococcus faecium (VRE) [9]. The aim of this study was to characterize at the molecular level the cytotoxic effects of compound 1 on human ERBB2 + breast cancer and normal breast epithelial cell lines to determine its potential use in cancer therapy.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…were fractionated by Si gel MPLC (Merck Kiesegel 60, 230-400 mesh, 200 g) (Merck, Darmstadt, Germany) eluting with n-hexane/CHCl3/CH3OH at concentrations varying from 100:0:0 to 0:0:100 (a: 3.0 L; b: 1.5 L) to obtain 16 fractions (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). [9] Fraction 9b (146.3 mg) (eluted with CHCl3, from 0.55 to 0.63 L) was purified by semipreparative RP HPLC (Symmetry 300 C18 column, 7.8x300 mm ID, 7 m particle size (Waters), flow rate of 2.0 mL/min, elution mixture composed of water (A) and CH3OH…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The novel diterpene 7β-acetoxy-20-hydroxy-19,20-epoxyroyleanone from Salvia corrugata shows complex cytotoxic activities against human breast epithelial cells

et al. 2019

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“…Antioxidant and antibacterial studies have been carried out in many legume plant species including Phyllanthus emblica (Singh and Sharma, 2015), Ziziphus mauritiana Lam. (Annathurai et al, 2015), Alkanna orientalis's roots (Petrosyan et al, 2015), Daucus carota's root, stem and petiole explants (Arafa et al, 2016), Salvia corrugata's leaf and stem explants (Bisio et al, 2016), Pterocarpus santalinu's leaf explants extracts (Ashrafee et al, 2014), Trigonella foenum-graecum's cotyledons and hypocotyls explants extracts etc. from the callus extracts (ElNour et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Callus induction and antibacterial activity of various explants of Indigofera zollingeriana

Maesaroh¹

2020

International Journal of Agriculture Environment and Food Sciences

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The study explore antibacterial potential of Indigofera zollingeriana, a popular medicinal and forage plant of the tropics. Methanol extracts of calli from hypocotyl, cotyledon and leaf excised from in vitro-grown plants using different plant growth regulator and their combinations had significant reaction against Gram-positive Staphylococcus aureus ATTCC25923 and Gram-negative Pseudomonas aeruginosa ATCC25823 bacteria. The best antibacterial activity was noted on the callus extracts of hypocotyl explants with significant inhibition zones on MS medium containing 2 mg/L BAP + 0.1 mg/L NAA. The P. aeruginosa had maximum inhibition on 0.5 mg/L BAP + 0.1 mg/L NAA. This antibacterial activity (by the hypocotyl induced calli extracts) was higher compared to the antibacterial activity noted from the extracts of other two explants and non treated control treatments. It was concluded that antibacterial activities were affected by explants source and plant growth regulators. The extracts from in vitro induced callus from hypocotyl, cotyledon and leaf explants of I.zollingeriana could be used variably and effectively against both type of bacteria used in this study.

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Establishment and analysis of in vitro biomass from Salvia corrugata Vahl. and evaluation of antimicrobial activity

Cited by 20 publications

References 53 publications

Absolute configuration of the diterpenoids icetexone and conacytone from Salvia ballotaeflora

Absolute configuration of the diterpenoids icetexone and conacytone from Salvia ballotaeflora

The novel diterpene 7β-acetoxy-20-hydroxy-19,20-epoxyroyleanone from Salvia corrugata shows complex cytotoxic activities against human breast epithelial cells

Callus induction and antibacterial activity of various explants of Indigofera zollingeriana

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