Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods

Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial

“…To address this issue, multiple research groups, including my own, have invested considerable resources in establishing optimised rodent pain models with back-translated pharmacological data, with the aim to more closely mimic individual chronic pain conditions in humans. 11 Examples include rat models of breast cancer–induced bone pain 95 and prostate cancer–induced bone pain, 39 , 69 rat models of antiretroviral toxic neuropathy (ATN) 53 , 117 and HIV-associated neuropathy, 118 the chronic phase of the monoidoacetate rat model of knee osteoarthritis, 34 a rat model of mechanical low back pain, 73 , 79 a mouse model of chronic low back pain, 62 mechanical nerve injury, 43 an EAE mouse model of central neuropathic pain, 45 , 46 , 48 a genetic model of painful diabetic neuropathy in the type 2 diabetic Zucker diabetic fatty rat, 24 , 77 , 93 as well as models of chemotherapy-induced peripheral neuropathy in both rats 32 , 33 , 60 and mice. 41 , 92 , 110 However, it is too early to draw conclusions on the effectiveness of this strategy to identify novel analgesic drug leads that will be more likely to achieve clinical trial success.…”