2023
DOI: 10.2139/ssrn.4366114
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Establishment and Validation of Ex-Vivo Calibration Curve for X-Ray Induced Dicentrics and Micronuclei in Human Lymphocytes for Biological Dose Estimation During Radiological Emergencies

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(7 citation statements)
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“…A dose-dependent increase in the number of cells exhibiting more than one DC formations was observed, with the notable nding that no instances of cells with two or more DC formations were observed up to 0.5 Gy, consistent with manual scoring observations. Statistical analysis con rmed a Poisson distribution for DC occurrences across all doses, consistent with earlier reports [10,11,23,33,34]. The dispersion index (u) and relative variance (σ²/Y) were calculated for each dose points, following the guidelines provided by the IAEA (Table 2) [24].…”
Section: Establishment Of Dose Response Curve For 60 Co-γ-ray Induced...supporting
confidence: 66%
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“…A dose-dependent increase in the number of cells exhibiting more than one DC formations was observed, with the notable nding that no instances of cells with two or more DC formations were observed up to 0.5 Gy, consistent with manual scoring observations. Statistical analysis con rmed a Poisson distribution for DC occurrences across all doses, consistent with earlier reports [10,11,23,33,34]. The dispersion index (u) and relative variance (σ²/Y) were calculated for each dose points, following the guidelines provided by the IAEA (Table 2) [24].…”
Section: Establishment Of Dose Response Curve For 60 Co-γ-ray Induced...supporting
confidence: 66%
“…10). Dose Estimates, freely available software, were employed for dose reconstruction [23]. The estimated doses for both DC and MN fell within the 95% con dence intervals, with further details of the estimated and delivered doses outlined in Table 7 for DC and Table 8 for MN.…”
Section: Validation Of Established Dose Response Curves By Dose Estim...mentioning
confidence: 94%
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