Inter-Satellite Links (ISLs) are intended to improve precision of orbit determination and satellite clock estimation. The ISLs provide a precise pseudorange measurements between satellites in a specific constellation. The study is a preparatory assessment of exploitation of seven connectivity schemes in the terms of the precise orbit determination for three types of constellations—Galileo-like with 24 satellites on three orbital planes, GPS-like with 24 satellites on six orbital planes, and GPS with real positions. The first part of the study focused on detailed analysis of the various ISL connectivity schemes, considering the geometry of ISL observations. The selected results of ranging were examined in the context of the precise orbit determination based on weighted least squares adjustment. The second part of the analysis was based on simulated measurements with two approaches. First approach focuses on geometrical dependencies and the second is performed with ISL measurement biases estimation. It was found that the use of the ISL technique with GNSS measurements in orbit determination improves the results by reducing the RMS error in the along-track and cross-track components. Choice of connectivity schemes does not have a significant impact on the total results of orbit determination, but give different contribution to particular components. Introducing constant bias in ISL measurements occurs in slightly worse estimation results. However, the relations between connectivity schemes is very similar to approach without simulation of ISL bias, the differences are at the level of 10%. Satellite and station clock estimation errors are almost equal for all used connectivity schemes. Results of clocks are also not influenced by ISL bias. This study showed that the ISL technique is a highly promising addition for future generations of satellite navigation systems and that sequential and ring connectivity schemes can be recommended for use in future navigation constellations.