Establishment of a combination scoring method for diagnosis of ocular adnexal lymphoproliferative disease

Qu, Xiaoli; Huang, Yan; Li, Kang; Yang, Xinji; Wang, Yi; Lu, Xiao-zhong; Xiao, Lan; Yang, Guang

doi:10.1371/journal.pone.0160175

Cited by 2 publications

(2 citation statements)

References 53 publications

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“…Most cases in our study show lymphovascular invasion (95.8%), which is an important histologic finding that distinguishes between RLH and MALT lymphoma. Other studies suggest that MALT lymphoma tends to occur in older age, has a predilection for the male sex, and tends to be localized, predominantly in the conjunctiva, compared with RLH [16,18,19]. A certain proportion of malignant transformation from RLH to malignant lymphoma has been reported, which is lower in the conjunctiva.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic Characteristics Associated with Prognosis in Ocular Extranodal Marginal Zone B Cell Lymphoma

et al. 2022

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Background and Objectives: Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT) type is the most common subtype of the ocular adnexal lymphoma. Despite its excellent prognosis, some patients experience partial remission or progressive disease. We aimed to evaluate clinicopathologic differences in the treatment responder group by comparing complete remission (CR) and non-complete remission (non-CR). Materials and Methods: This study retrospectively reviewed 48 patients who were diagnosed with ocular adnexal MALT lymphoma at Ulsan University Hospital between March 2002 and August 2018. Patients who were followed up for less than 6 months were excluded. Histologic and clinical features were analyzed. The patients were divided into two groups: CR and non-CR. Results: Among the 48 patients, 33 achieved CR and 15 achieved non-CR during the median follow-up period of 40.00 months (range, 7–109 months). In univariable analysis, more patients tend to undergo treatment in the CR group, and post-radiotherapy (post-RT) SUVmax, PET and serum lactate dehydrogenase (LDH) levels were higher in the non-CR group (p = 0.043, p = 0.016, and p = 0.042, respectively). In a multivariable analysis, only application of treatment, including radiotherapy or chemotherapy with immunotherapy, was related to CR (odd ratio 7.301, 95% confidence interval 1.273–41.862, p = 0.026). In subgroup analysis according to the site of involvement, none of the variables were significant except for the post-RT SUVmax of PET and level of serum LDH in the non-conjunctiva group (p = 0.026, and p = 0.037, respectively). Seven (14.6%) patients had a recurrence, and those with a recurring site other than the primary site had a higher Ki-67 labeling index, although it was not statistically significant (9.56% vs. 18.00%, p = 0.095). Conclusions: Although belonging to the early stages, the non-CR rate was high in patients with high serum LDH levels, and recurred patients had higher Ki-67. Thus, considering active treatment is recommended in this group of patients.

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Section: Discussionmentioning

confidence: 99%

Clinicopathologic Characteristics Associated with Prognosis in Ocular Extranodal Marginal Zone B Cell Lymphoma

et al. 2022

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“…Normal lymphoid tissue in the ocular region remains confined to the eyelid, conjunctiva, and lacrimal gland [2]. Lymphoid proliferations of the ocular adnexa constituted 10-24.7% of primary ocular adnexal tumors [3]. Lymphoid proliferations have variety of lesions ranging from benign lymphoid hyperplasia (LH) to malignant lymphomas [4].…”

Section: Introductionmentioning

confidence: 99%

Primary Orbital Lymphoma – A Rare Challenging Diagnostic Entity

Marwah

Dalal

Satiza

et al. 2020

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The diagnosis of lymphoproliferative disorder of orbit is quite challenging as both Pseudolymphomas and Non‑Hodgkin’s lymphomas can occur in orbit. Primary orbital lymphoma is a rare entity comprising of 1-2% of Non‑Hodgkin’s lymphoma, majority of them are B‑cell type. It is a slow growing tumor. It presents in the age group of 50–70 years, with a slight female preponderance. Proptosis is the most common presentation. We, herein, report a case of 48 years old male presenting with right non-axial proptosis, watering of eye, blurring of vision and redness for the last 9 months. After thorough clinical and radiological evaluation, a biopsy was taken for histopathological examination. A primary diagnosis of Lymphoproliferative Disorder was made. Following this, a panel of immunohistochemical markers was applied and a final diagnosis of Non-Hodgkin Lymphoma, B-cell type was given.

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Establishment of a combination scoring method for diagnosis of ocular adnexal lymphoproliferative disease

Cited by 2 publications

References 53 publications

Clinicopathologic Characteristics Associated with Prognosis in Ocular Extranodal Marginal Zone B Cell Lymphoma

Clinicopathologic Characteristics Associated with Prognosis in Ocular Extranodal Marginal Zone B Cell Lymphoma

Primary Orbital Lymphoma – A Rare Challenging Diagnostic Entity

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