2024
DOI: 10.3389/fphar.2024.1399625
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Establishment of a prognostic risk model for osteosarcoma and mechanistic investigation

Hongyuan Jiang,
Xuliang Zhao,
Jinhui Zang
et al.

Abstract: Objective: To investigate the immune mechanism of osteosarcoma (OS)-specific markers to mitigate bone destruction in the aggressive OS, prone to recurrence and metastasis.Methods: Gene expression patterns from the Gene Expression Omnibus (GEO) database (GSE126209) were analyzed using weighted gene co-expression network analysis (WGCNA), protein-protein interaction (PPI) analysis, least absolute shrinkage and selection operator (LASSO) modeling, and survival analysis to identify charged multivesicular body prot… Show more

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