Establishment of an immunoglobulin A–deficient blood donor registry with a simple in‐house screening enzyme‐linked immunosorbent assay

Thibault, Louis; Beauséjour, Annie; Grandmont, Marie Joëlle de; Long, Anne; Goldman, Mindy; Chevrier, Marie-Claire

doi:10.1111/j.1537-2995.2006.01037.x

Cited by 17 publications

(20 citation statements)

References 37 publications

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“…Many anti-IgA antibodies occur naturally; in one study, only 9 out of the 39 blood donors with detectable anti-IgA antibodies had a history of transfusion or pregnancy. 6 It could be that sensitisation occurs in utero by maternal IgA crossing the placenta and entering the foetal circulation. Alternatively, human breast milk IgA, or bovine IgA, could be absorbed via the intestinal wall and cause sensitisation.…”

Section: Discussionmentioning

confidence: 99%

An acute transfusion reaction

2018

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We present the case of a 67-year-old man who suffered an acute anaphylactic reaction during red cell transfusion due to the presence of anti-IgA antibodies. The incidence and clinical relevance of anti-IgA antibodies in IgA defi ciency is reviewed, and the wider investigation and management of acute transfusion reactions is also discussed. This case highlights the need to consider the potential risks of blood component transfusion against the purported benefi t.

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Section: Discussionmentioning

confidence: 99%

An acute transfusion reaction

2018

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“…In addition, many registries of blood donors with IgA deficiency have been established in different countries [4,5,6]. Nevertheless, anaphylactic reactions due to anti-IgA cannot invariably be prevented.…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that such reactions can be prevented by providing IgA-deficient blood components collected from IgA-deficient blood donors. Based on this option, registries of such donors have been established in the USA, Canada, and some countries in Europe and Asia [4,5,6,7]. However, in practice, the use of these rare products cannot be realized in many instances, particularly in emergencies or where platelets are required [7].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Treatment and Transfusion of Normal Blood Components Following Tolerance Induction in Patients with Anti-IgA Anaphylactic Reactions

Salama

Kardashi

Arbach

2014

Transfus Med Hemother

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Background: In general, patients with significant anti-Ig-A do not tolerate intravenous (i.v.) administration of normal blood products. Here, we present our experiences in the induction of immune tolerance (IIT) and long-term treatment in a series of such patients affected in such a way. The question whether blood components from IgA-deficient donors are required will be discussed. Methods: Ten adult patients (4 females and 6 males; age ranging from 36 to 75 years) with anti-IgA were included in this study. All patients required long-term treatment with blood components. One patient had IgA deficiency and paroxysmal nocturnal hemoglobinuria (PNH), and all other patients had common variable immunodeficiency (CVID). The particle gel immunoassay was used for the detection of anti-IgA. Immune tolerance to IgA was induced by controlled subcutaneous (s.c.) and/or i.v. infusions of IgG preparations. Results: Prior to IIT, anti-IgA was detectable in plasma samples of all patients and significantly diminished or abolished by controlled s.c. and/or i.v. infusions of IgG. Multiple transfusions with normal blood components could be repeatedly performed with the patient suffering from PNH without any complications. As long as i.v. IgG (IVIgG) infusions were consequently administered as individually required (intervals 2-8 weeks), none of the patients developed reactions during observation (up to 10 years). However, interruption of treatment and re-exposure to IVIgG resulted in adverse reactions. Conclusion: Patients with significant anti-IgA can be safely desensitized and tolerate long-term IgG substitutions independent of the IgA concentration of the used blood component.

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“…This is because autologous blood is not available for patients with excessive blood loss, and washing RBCs and PLTs is timeconsuming, laborious and limits their activity. Many countries have developed large-scale detection methods for IgA deficiency, and registries of IgA-deficient donors have been established in Canada, the United States and in some European countries (Thibault et al, 2006). These actions support the rare occurrence of IgA-negative blood transfusion to IgA-deficient persons, minimising the incidence rate of adverse transfusion reactions and enhancing blood safety.…”

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confidence: 99%

Prevalence of immunoglobulin A deficiency in Chinese blood donors and evaluation of anaphylactic transfusion reaction risk

Shen

et al. 2011

Transfusion Medicine

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Establishment of an immunoglobulin A–deficient blood donor registry with a simple in‐house screening enzyme‐linked immunosorbent assay

Abstract: With a simple in-house ELISA, 73 blood donors were identified as IgA-deficient. From this number, 34 donors, without detectable anti-IgA in their plasma, were added to our IgA-deficient blood donor panel to maximize the management of our inventory of IgA-deficient frozen blood components.

Cited by 17 publications

References 37 publications

An acute transfusion reaction

An acute transfusion reaction

Long-Term Treatment and Transfusion of Normal Blood Components Following Tolerance Induction in Patients with Anti-IgA Anaphylactic Reactions

Prevalence of immunoglobulin A deficiency in Chinese blood donors and evaluation of anaphylactic transfusion reaction risk

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