Establishment of fetal Sertoli cells and their role in testis morphogenesis

Yao, Haibo; Ungewitter, Erica; Franco, Heather L.; Capel, Blanche

doi:10.1016/b978-0-12-417047-6.00002-8

Cited by 12 publications

(15 citation statements)

References 145 publications

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“…The establishment of Sertoli cells from somatic cell lineage is initiated by the Sry gene, encoding for the transcription factor Sex Determining Region Y (SRY) ( 9 ). The indispensable and remarkable role of SRY is demonstrated by the existence of XY humans with frameshift or single base mutations in Sry gene who develop as phenotypic females, whereas the significant expression of Sry gene in an XX individual, mainly due to abnormal Sry translocation to a X chromosome, leads gonads to develop along the male sexual axis ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of endocrine disrupting chemicals and pharmaceuticals on Sertoli cell development and functions

Corpuz-Hilsabeck

Culty

2023

Front. Endocrinol.

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Sertoli cells play essential roles in male reproduction, from supporting fetal testis development to nurturing male germ cells from fetal life to adulthood. Dysregulating Sertoli cell functions can have lifelong adverse effects by jeopardizing early processes such as testis organogenesis, and long-lasting processes such as spermatogenesis. Exposure to endocrine disrupting chemicals (EDCs) is recognized as contributing to the rising incidence of male reproductive disorders and decreasing sperm counts and quality in humans. Some drugs also act as endocrine disruptors by exerting off-target effects on endocrine tissues. However, the mechanisms of toxicity of these compounds on male reproduction at doses compatible with human exposure are still not fully resolved, especially in the case of mixtures, which remain understudied. This review presents first an overview of the mechanisms regulating Sertoli cell development, maintenance, and functions, and then surveys what is known on the impact of EDCs and drugs on immature Sertoli cells, including individual compounds and mixtures, and pinpointing at knowledge gaps. Performing more studies on the impact of mixtures of EDCs and drugs at all ages is crucial to fully understand the adverse outcomes these chemicals may induce on the reproductive system.

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Section: Introductionmentioning

confidence: 99%

Impact of endocrine disrupting chemicals and pharmaceuticals on Sertoli cell development and functions

Corpuz-Hilsabeck

Culty

2023

Front. Endocrinol.

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“…The high expression of TGF-β1 in the testis can affect the normal spermatogenic function of the body (Yao et al, 2015). Because Leydig cells are the main site for the conversion of androgen into estrogen, and in male sexual maturity, TGF-β1 is mainly expressed in Leydig cells, while they are mainly found in the testicular stroma.…”

Section: Effect Of Tgf-β1 On Leydig Cellsmentioning

confidence: 99%

Advances in research of TGF-Β1 in human testis

et al. 2022

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Transforming growth factor β1 (TGF-β1) is a polypeptide growth factor with various biological activities. Recent studies have shown that this growth factor and they receptors are expressed in human Leydig cells, Sertoli cells, spermatogonia, spermatocytes and sperm cells after birth, and are involved in the endocrine regulation of spermatogenesis. However, there is no report on the expression of TGF-β in human embryonic testis. TGF-β1 is a peptide growth factor widely distributed in germ cells at various levels in the testis, regulating the function of the testes and maintaining the stability of the testis environment by acting on various cells. This review summarizes the research progress of TGF-β1 in human testis.

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“…SSCs maintain the continuous sperm production required for male fertility [ 13 , 30 , 31 , 32 ]. SSC precursors originate from the embryonic bipotent primordial germ cells (PGCs) that migrate from the proximal epiblast to the gonadal ridge, where they are enclosed by Sertoli and peritubular myoid cells, forming the seminiferous cords [ 10 , 33 , 34 , 35 ].…”

Section: Development Of the Male Gonad And Establishment Of Spermamentioning

confidence: 99%

Metabolic Requirements for Spermatogonial Stem Cell Establishment and Maintenance In Vivo and In Vitro

Voigt

Thiageswaran

Lara

et al. 2021

IJMS

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The spermatogonial stem cell (SSC) is a unique adult stem cell that requires tight physiological regulation during development and adulthood. As the foundation of spermatogenesis, SSCs are a potential tool for the treatment of infertility. Understanding the factors that are necessary for lifelong maintenance of a SSC pool in vivo is essential for successful in vitro expansion and safe downstream clinical usage. This review focused on the current knowledge of prepubertal testicular development and germ cell metabolism in different species, and implications for translational medicine. The significance of metabolism for cell biology, stem cell integrity, and fate decisions is discussed in general and in the context of SSC in vivo maintenance, differentiation, and in vitro expansion.

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Establishment of fetal Sertoli cells and their role in testis morphogenesis

Cited by 12 publications

References 145 publications

Impact of endocrine disrupting chemicals and pharmaceuticals on Sertoli cell development and functions

Impact of endocrine disrupting chemicals and pharmaceuticals on Sertoli cell development and functions

Advances in research of TGF-Β1 in human testis

Metabolic Requirements for Spermatogonial Stem Cell Establishment and Maintenance In Vivo and In Vitro

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