An issue related to using SIP panels for building structures is to ensure their stability and durability during operation in wide ranges. Therefore, the object of research was the change in the properties of wood-polymer material in case of fire and its protection when applied with a reactive coating capable of forming a pinocoke layer under the influence of high temperature on the coating. It has been proven that in the process of thermal action on the fire-resistant coating, the heat insulation process of SIP panels involves the formation of soot-like products on the surface of the material. Thus, under the action of the radiation panel on the surface of the OSB sample, after 120 s of thermal exposure, the process of intensive formation of a layer of foam coke, which thermally insulated the wood-polymer material, began; instead, after the radiation panel was exposed to the fire-resistant polystyrene foam sample, the process of destruction began at a temperature of about 100 °C polystyrene foam. When determining the flammability of a fire-resistant SIP panel, it was established that the temperature of the flue gases during the tests was no more than 110 °C, the length of the damaged sample did not exceed 460 mm. At the same time, the mass loss did not exceed 200 g, and independent combustion of the SIP panel sample did not occur despite the high temperature. According to these data, the SIP panel, fire-resistant with a reaction coating, belongs to group G1 (low flammability) and is a non-flammable material. The practical significance is that the results were taken into account during the design of buildings from SIP panels. So, there are reasons to assert the possibility of targeted regulation of the fire protection processes of SIP panels through the use of reactive coatings capable of forming a protective layer on the surface of the material that inhibits the rate of heat transfer