2022
DOI: 10.7324/jabb.2022.100516
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Establishment of Mucuna pruriens (L.) DC. callus and optimization of cell suspension culture for the production of anti-Parkinson’s drug: L-DOPA

Abstract: It has become a huge challenge to satisfy the emerging demand for levo-3,4-dihydroxyphenylalanine (L-DOPA), an anti-Parkinson's drug in the international drug market. This is attributed to the conventional methods of extraction from the natural sources of Mucuna spp., which has a low germination rate, less viable seeds, and an irritating, itching trichomes on the pods. The need for an alternative method with continuous supply of L-DOPA without affecting the natural biodiversity has been achieved through in vit… Show more

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Cited by 5 publications
(1 citation statement)
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“…VBs synthesize the non-protein amino acid (3, 4 dihydroxyl phenyl)-l-alanine (L-Dopa); a strong neurotransmitter precursor is thought to be responsible for velvet beans seeds' toxicity (Rakesh & Praveen, 2020). It also contains compounds like glutathione, lecithin, gallic acid, and beta-sitosterol as well as oils including stearic, oleic, linoleic, and palmitic acids (Divya et al, 2017).…”
Section: Phytochemical Constituentsmentioning
confidence: 99%
“…VBs synthesize the non-protein amino acid (3, 4 dihydroxyl phenyl)-l-alanine (L-Dopa); a strong neurotransmitter precursor is thought to be responsible for velvet beans seeds' toxicity (Rakesh & Praveen, 2020). It also contains compounds like glutathione, lecithin, gallic acid, and beta-sitosterol as well as oils including stearic, oleic, linoleic, and palmitic acids (Divya et al, 2017).…”
Section: Phytochemical Constituentsmentioning
confidence: 99%