Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys

Wang, Yutang; Charchar, Fadi J.

doi:10.21203/rs.3.rs-253600/v1

Cited by 7 publications

(8 citation statements)

References 30 publications

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“…Our study also indicates that testosterone could promote higher levels of kidney function markers ( i.e ., creatinine and uric acid) since subjects with basal and restored testosterone levels showed an increased abundance of these metabolites (Table 2 and Figure 4D). These findings are in agreement with a recent study where higher testosterone was associated with an increment in uric acid levels in adolescent boys 33 , and a case report of hypogonadism where renal function decreased after testosterone replacement therapy, increasing creatinine levels 34 . However, considering that creatinine is also involved in muscle metabolism, the positive correlation between testosterone and creatinine might reflect the increase in muscle mass and not an impairment in renal function 35 .…”

Section: Discussionsupporting

confidence: 93%

Metabolic changes induced by pharmacological castration of young, healthy men: a study of the plasma metabolome

Guedes

Plá

Sahlin

et al. 2022

Preprint

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Testosterone is a hormone that plays a key role in carbohydrate, fat, and protein metabolism. Testosterone deficiency is associated with multiple comorbidities, e.g., metabolic syndrome and type 2 diabetes. Despite its importance in many metabolic pathways, the mechanisms by which it controls metabolism are not fully understood. The present study investigated the short-term metabolic changes of pharmacologically induced castration and testosterone supplementation in healthy young males. Thirty subjects were submitted to testosterone depletion (TD) followed by testosterone supplementation (TS). Plasma samples were collected three times corresponding to basal, low, and restored testosterone levels. An untargeted metabolomics study was performed by liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) to monitor the metabolic changes induced by the altered hormone levels. Our results demonstrated that TD is associated with major metabolic changes partially restored by TS. Carnitine and amino acid metabolism were the metabolic pathways most impacted by variations in testosterone. Furthermore, our results also indicate that LH and FSH might strongly alter the plasma levels of indoles and lipids, especially glycerophospholipids and sphingolipids. Our results demonstrate major metabolic changes induced by low testosterone that may be important for understanding the mechanisms behind the association of testosterone deficiency and its comorbidities.

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Section: Discussionsupporting

confidence: 93%

Metabolic changes induced by pharmacological castration of young, healthy men: a study of the plasma metabolome

Guedes

Plá

Sahlin

et al. 2022

Preprint

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“…Confounding covariates were similar to the previous publications 11–13,17,18 and included age (continuous), sex (male or female), ethnicity (Non‐Hispanic White, Non‐Hispanic Black, Mexican‐American, or other), obesity (underweight, normal, overweight, obese, or unknown), poverty‐income ratio (<130%, 130%–349%, ≥350%, or unknown), education (<high school, high school, >high school, or unknown), and survey periods (1988–1991, 1991–1994, 1999–2000, 2001–2002, 2003–2004, 2005–2006, 2007–2008, 2009–2010, 2011–2012, or 2013–2014). Lifestyle confounders included physical activity (inactive, insufficiently active, active, or unknown), alcohol consumption (never, <1 drink per week, 1–6 drinks per week, ≥7 drinks per week, or unknown), and smoking status (past smoker, current smoker, nonsmoker, or unknown).…”

Section: Methodsmentioning

confidence: 99%

Fasting status modifies the association between triglyceride and all‐cause mortality: A cohort study

Fang

Wang

2022

Health Science Reports

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Background and Aims: Both fasting and non-fasting levels of triglyceride have been shown positively associated with all-cause mortality. It is unknown whether fasting status modifies this association. This study aimed to address this question.Methods: This study included 34,512 US adults (27,036 fasting and 7476 nonfasting participants). All-cause mortality was ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios of triglyceride for mortality.Results: This cohort was followed up for a mean of 13.0 years. During the follow-up, 8491 all-cause deaths were recorded. A 1-natural-log-unit increase in triglyceride was associated with an 8% higher multivariate-adjusted risk of all-cause mortality.Interaction analyses showed that fasting status interacted with triglyceride in predicting all-cause mortality. Sub-analyses showed that a 1-natural-log-unit increase in triglyceride was associated with a 17% higher multivariate-adjusted risk of all-cause mortality in the nonfasting subcohort; however, there lacked such an association in the fasting sub-cohort. Similarly, high (200-499 mg/dL) and very high levels of triglyceride (≥500 mg/dL) were associated with higher all-cause mortality risks compared with low normal triglyceride (<100 mg/dL) only in the nonfasting subcohort. Conclusion:This study found that, compared to fasting triglyceride, nonfasting triglyceride was more sensitive in predicting all-cause mortality. This study supports the initiatives by some guidelines to recommend the use of nonfasting triglycerides for risk assessment.

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“…It was observed that there was a different relationship between sUA and HNT in people of different genders [19]. Previous studies [21] have shown that Figure 3: Association between sUA and HTN stratified by sex. Age, race, income-poverty ratio, physical activity, smoking behavior, alcohol consumption, diabetes mellitus status, body mass index, total cholesterol, serum homocysteine, urine creatinine, blood urea nitrogen, and total calcium were adjusted.…”

mentioning

confidence: 86%

The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults

Xu¹,

Huang

et al. 2021

Cardiovascular Therapeutics

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Background. Studies on serum uric acid (sUA) levels and hypertension (HTN) are controversial. To investigate the association between the sUA level and the incident of HTN in middle-aged and elderly adults, we performed this study. Methods. 6399 participants aged ≥40 years from the National Health and Nutrition Examination Survey (NHANES) were included. Weighted multiple logistic regression analysis was carried out to evaluate the relationship between the sUA level and the incident of HTN, exploring the potential nonlinear relationship using the fitted smoothing curves. If nonlinearity was observed, the inflection point was further calculated by a recursive algorithm. Results. A positive relationship between the sUA level and the incident of HTN was found. However, it may differ in different race groups, nor between male and female. Moreover, the association between the sUA level and the incident of HTN followed a U-shaped curve in male (turning point: sUA 4.1 mg/dL) and Whites (turning point: sUA 7.9 mg/dL). Conclusions. The results revealed that the sUA level is positively correlated with the incident of HTN, in middle-aged and elderly adults. However, it followed a U-shaped curve in males and Whites.

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Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys

Cited by 7 publications

References 30 publications

Metabolic changes induced by pharmacological castration of young, healthy men: a study of the plasma metabolome

Metabolic changes induced by pharmacological castration of young, healthy men: a study of the plasma metabolome

Fasting status modifies the association between triglyceride and all‐cause mortality: A cohort study

The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults

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