Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys

Wang, Yutang; Charchar, Fadi J.

doi:10.1038/s41598-021-96959-4

Cited by 37 publications

(27 citation statements)

References 38 publications

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“…Experts suspected that the lower reference value of SUA in women might be related to estrogen inhibiting xanthine oxidase that produces UA (35,36). However, a large representative cohort study in the US found that gender differences in UA levels are formed during adolescence (37). However, our study found that SUA levels were more likely to be affected by total CA levels in adolescent girls than boys.…”

Section: Discussioncontrasting

confidence: 72%

Association of Total Calcium With Serum Uric Acid Levels Among United States Adolescents Aged 12–19 Years: A Cross-Sectional Study

Luo

Jin

et al. 2022

Front. Med.

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AimsEvidence of a link between total calcium (CA) and serum uric acid (SUA) is absent in adolescents. Thus, this study aimed to determine the relationship between total CA levels and SUA levels in United States adolescents.MethodsA cross-sectional study analyzed a sample composed of 8,309 United States adolescents aged 12–19 years from the National Health and Nutrition Examination Survey database (1999–2006 survey cycle). Multivariable linear regression analyses and multivariable logistic regression analyses were used to assess the correlation of total CA with SUA levels and hyperuricemia. Furthermore, the dose-response relationship of total CA and SUA levels was analyzed using smooth curve fitting (penalized spline method).ResultsAccording to multivariable linear regression analysis, every 1 mg/dL increase in total CA level is associated with a 0.33 mg/dL (β = 0.33, 95% CI: 0.27–0.40, p < 0.001) increase in SUA. Multivariable logistic regression analyses showed that every 0.1 mg/dL increase in total CA level is linked with an 8% increased risk of hyperuricemia (OR = 1.08, 95% CI: 1.06–1.10, p < 0.001). The analyses of smooth curve fitting revealed that total CA levels were linearly correlated with SUA levels (Pnon–linearity = 0.152). The results were highly stable in all subgroups. The interaction analysis results presented that race/ethnicity had an interactive role in associating total CA with SUA levels.ConclusionsIn United States adolescents, total CA levels were linearly and positively correlated with SUA levels.

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Section: Discussioncontrasting

confidence: 72%

Association of Total Calcium With Serum Uric Acid Levels Among United States Adolescents Aged 12–19 Years: A Cross-Sectional Study

Luo

Jin

et al. 2022

Front. Med.

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“…4 D). These findings are in agreement with a recent study where higher testosterone was associated with an increment in uric acid levels in adolescent boys 34 , 35 , and a case report of hypogonadism where renal function decreased after testosterone replacement therapy and creatinine levels increased 36 . However, considering that creatinine is also involved in muscle metabolism, the positive correlation between testosterone and creatinine might reflect the increase in muscle mass and not an impairment in renal function 37 .…”

Section: Discussionsupporting

confidence: 93%

Plasma metabolome study reveals metabolic changes induced by pharmacological castration and testosterone supplementation in healthy young men

Guedes

Plá

Sahlin

et al. 2022

Sci Rep

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Testosterone is a hormone that plays a key role in carbohydrate, fat, and protein metabolism. Testosterone deficiency is associated with multiple comorbidities, e.g., metabolic syndrome and type 2 diabetes. Despite its importance in many metabolic pathways, the mechanisms by which it controls metabolism are not fully understood. The present study investigated the short-term metabolic changes of pharmacologically induced castration and, subsequently, testosterone supplementation in healthy young males. Thirty subjects were submitted to testosterone depletion (TD) followed by testosterone supplementation (TS). Plasma samples were collected three times corresponding to basal, low, and restored testosterone levels. An untargeted metabolomics study was performed by liquid chromatography–high resolution mass spectrometry (UHPLC–HRMS) to monitor the metabolic changes induced by the altered hormone levels. Our results demonstrated that TD was associated with major metabolic changes partially restored by TS. Carnitine and amino acid metabolism were the metabolic pathways most impacted by variations in testosterone. Furthermore, our results also indicated that LH and FSH might strongly alter the plasma levels of indoles and lipids, especially glycerophospholipids and sphingolipids. Our results demonstrated major metabolic changes induced by low testosterone that may be important for understanding the mechanisms behind the association of testosterone deficiency and its comorbidities.

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“…Sex hormones could be part of the differences between genders due to their effect on circulating uric acid, eGFR level, and muscle strength. During adolescence, higher testosterone and lower sex hormone-binding globulin were reported as the gender difference in circulating uric acid [29].…”

Section: Discussionmentioning

confidence: 99%

Higher serum uric acid with a high eGFR is associated with decreased risk of low muscle strength in aged population: a retrospective cohort study

Huang

Chen

Duan

et al. 2022

Preprint

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BackgroundWe aimed to investigate the interaction between serum uric acid levels with estimated glomerular filtration rate (eGFR) to low muscle strength (LMS) in a large Chinese elderly population.MethodsCohort data were obtained from China Health and Retirement Longitudinal Study (CHARLS) in 2011 and 2015. Two thousand seven hundred forty-five community-dwelling older participants were enrolled for the follow-up. Serum uric acid was collected after 8 hours of fasting, and handgrip strength was measured with a dynamometer. eGFR was calculated with an equation based on the Chinese population. A generalized additive model was employed for interaction analysis and progressively adjusted confounders.ResultsIn this study, we found that men with a low eGFR (<60 mL/min/1.73 m2) reported higher SUA levels (5.91 ± 1.27) and older (72.53 ± 6.38) than those who had a high eGFR while women share the same difference with a lower eGFR in higher SUA levels (5.00 ± 1.34) and older (72.81 ± 6.83). After progressively adjusting covariates, in females, the OR for higher eGFR with higher SUA level remained significantly with low muscle strength (OR=0.80 95%CI=0.68-0.95 P=0.0102). This correlation, however, was not observed in men.ConclusionsThis population-based cohort study in Chinese revealed that high serum uric acid level with higher eGFR seems to be significantly associated with a lower risk of low muscle strength in the elderly, especially in females.

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Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys

Cited by 37 publications

References 38 publications

Association of Total Calcium With Serum Uric Acid Levels Among United States Adolescents Aged 12–19 Years: A Cross-Sectional Study

Association of Total Calcium With Serum Uric Acid Levels Among United States Adolescents Aged 12–19 Years: A Cross-Sectional Study

Plasma metabolome study reveals metabolic changes induced by pharmacological castration and testosterone supplementation in healthy young men

Higher serum uric acid with a high eGFR is associated with decreased risk of low muscle strength in aged population: a retrospective cohort study

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