2002
DOI: 10.1136/gut.51.2.259
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Establishment of standardised SLA/LP immunoassays: specificity for autoimmune hepatitis, worldwide occurrence, and clinical characteristics

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Cited by 173 publications
(186 citation statements)
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“…In addition, anti-soluble liver antigen (anti-SLA) antibodies serve as highly specific serological markers for AIH and exhibit 99% specificity for diagnosing this disease (30)(31)(32)(33). Anti-SLA antibodies have been found in 11%-22% of white North American and northern European adult patients with type 1 AIH and are common (18%-44% incidence) in children with type 1 and type 2 AIH (30,(34)(35)(36).…”
Section: Traf6δtec Mice Exhibit Classic Hallmarks Of Aih Such As Thementioning
confidence: 99%
“…In addition, anti-soluble liver antigen (anti-SLA) antibodies serve as highly specific serological markers for AIH and exhibit 99% specificity for diagnosing this disease (30)(31)(32)(33). Anti-SLA antibodies have been found in 11%-22% of white North American and northern European adult patients with type 1 AIH and are common (18%-44% incidence) in children with type 1 and type 2 AIH (30,(34)(35)(36).…”
Section: Traf6δtec Mice Exhibit Classic Hallmarks Of Aih Such As Thementioning
confidence: 99%
“…Its presence identifies patients with a more severe disease and a worse outcome. It is also associated with HLA-DR3 (28,29) .Anti-LC1 is the second marker of AIH-2, detected in 24% to 32% of patients with anti-LKM1 and rarely as the only marker of AIH-2. It occurs mainly in young patients with an aggressive disease course with rapid progression to cirrhosis (30,31) .…”
Section: Diagnosismentioning
confidence: 99%
“…Progress has been made in the definition of other autoantibodies frequently present in AIH but undetectable by IFL including antibodies against SLA/LP [51,[81][82][83][84][85] and ASGPR. Most of anti-SLA/LP positive patients are also positive for ANA, SMA or anti-LKM1, but occasionally anti-SLA is present in isolation and, in this case, its detection is of diagnostic importance [81,86] .…”
Section: Sla/lp and Asgprmentioning
confidence: 99%
“…Most of anti-SLA/LP positive patients are also positive for ANA, SMA or anti-LKM1, but occasionally anti-SLA is present in isolation and, in this case, its detection is of diagnostic importance [81,86] . The identification of the molecular target of anti-SLA/LP antibodies as the UGA serine tRNA-associated protein has led to the development of ELISA or dot-blot assays increasingly replacing the conventional inhibition ELISA originally used for anti-SLA antibody detection [51,83] . Recent studies investigating the exact role of this protein have shown that SLA/LP is a selenocysteine synthase but how the biosynthesis of selenocysteine may relate to the pathogenesis of AIH is not known [87] .…”
Section: Sla/lp and Asgprmentioning
confidence: 99%
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