Establishment of Yan-Zhang's staging of digestive tract magnetic compression anastomosis in a rat model

Abstract

Magnetic compression anastomosis, also known as magnamosis, is a safe and feasible method for digestive tract anastomosis. However, the pathological process involved in magnamosis of the digestive tract has not been investigated. This study aimed to establish the stages of digestive tract magnamosis in a rat model. Eighty-four Sprague–Dawley albino rats (200–250 g) were randomly divided into 14 groups (n = 6 per group). All rats underwent colonic magnamosis. Starting from postoperative day (POD) 1, one group of rats was sacrificed every other day to obtain the specimens. Burst pressure at the anastomotic site of each specimen was examined. Gross and histological examination of the anastomotic site was performed to establish the stages of the digestive tract magnamosis. Colonic magnamosis was successfully performed in all rats and the mean anastomosis time was 5.62 ± 0.91 min. The postoperative survival rate was 100%. The lowest anastomotic burst pressure was 78.33 ± 3.44 mmHg on POD3. The anastomotic burst pressure gradually increased and stabilized on POD21. Macroscopic and histological examination showed that the anastomotic mucosal and serosal layer did not heal on POD1. The serosal layer of the anastomosis healed by adhesion on POD3, and the mucosal layer began to heal on POD3-11 and was established by POD21. According to the anastomotic bursting pressure, digestive tract magnamosis can be staged into the magnetic maintenance, fragile, strengthening, and stable phases, which on histology correspond to the serosal adhesion formation, serosal healing, mucosal healing, and stereotyping, respectively.

Novel magnetic compression technique for the treatment of postoperative anastomotic stenosis in rectal cancer: A case report

“…Firstly, in the treatment of rectal anastomotic stenosis by MCT, the scar of anastomotic hyperplasia is located between the magnets. The continuous magnetic compression induces the pathological change sequence of ischemia-necrosis-shedding[ 21 ]. The primary distinction between MCT and other methods like balloon dilation and radial incision lies in the removal of scar tissue.…”

Optimization of tracheoesophageal fistula model established with T-shaped magnet system based on magnetic compression technique

“…With the magnetic compression technique, upon placement of magnets in the empty organs where anastomosis is to occur, the magnets are attracted together, and the compressed tissue undergoes pathological changes of ischemia, necrosis, and shedding[ 8 ], resulting in the establishment of a new channel. The magnetic compression technique can be used for vascular anastomosis[ 9 - 11 ], digestive anastomosis[ 12 - 15 ] and ureteral anastomosis[ 16 , 17 ].…”

Influence of different magnetic forces on the effect of colonic anastomosis in rats

“…Other examples include vascular[ 10 - 11 ] and ureterovesical[ 12 ] anastomosis. During MCA of the digestive tract, the pathological process is ischemia-necrosis-shedding in the compressed tissues between the magnets and adherence-repair-healing in the surrounding tissues[ 13 ].…”