Estatus epiléptico y demencia rápidamente progresiva en una mujer de 90 años: enfermedad de Creutzfeldt-Jakob esporádica

Sanabria, Miguel Oswaldo Cadena; Baez, Manuel Ardila; Prada, Libardo Rueda

doi:10.1016/j.regg.2014.10.009

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…Our literature search on prion diseases revealed that one case of scrapie in 1981 and 29 human sporadic cases of CJD (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32) have been documented and published in our country. To our knowledge, there are no records or evidence of vCJD or bovine spongiform encephalopathy in Colombia (28,33,34).…”

Section: Discussionmentioning

confidence: 99%

Positive 14-3-3 and tau proteins in a sporadic Creutzfeldt-Jakob disease case and a brief perspective of prion diseases in Colombia

Escandón-Vargas¹,

Zorrilla-Vaca²,

Corral-Prado³

2016

biomedica

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Prion diseases are rare neurodegenerative disorders occurring worldwide and affecting both humans and animals. Herein, we present the case of a patient diagnosed with definite sporadic CreutzfeldtJakob disease in Cali, Colombia. Besides neurological examination, 14-3-3 and tau proteins were valuable tools supporting the diagnosis. We also present a brief perspective of the prion diseases reported in Colombia to date. Although the incidence of prion diseases is unknown in Colombia, our literature review revealed that one case of scrapie in 1981 and 29 human sporadic cases of Creutzfeldt-Jakob disease have been documented and published in our country.Key words: Creutzfeldt-Jakob syndrome, prions, case reports. doi: http://dx.doi.org/10.7705/biomedica.v36i3.2729 Proteínas 14-3-3 y tau positivas en un caso de enfermedad esporádica de Creutzfeldt-Jakob y una breve reseña de las enfermedades priónicas en Colombia Las enfermedades priónicas son alteraciones neurodegenerativas raras que ocurren en todo el mundo y afectan tanto a humanos como a animales. En el presente artículo, se reporta un caso con diagnóstico confirmado de enfermedad esporádica de Creutzfeldt-Jakob. Además del examen neuropatológico, las proteínas 14-3-3 y tau fueron herramientas valiosas que ayudaron en el diagnóstico. También, se presenta una breve reseña de las enfermedades priónicas reportadas en Colombia hasta la fecha. Aunque en el país se desconoce la incidencia de las enfermedades priónicas, nuestra búsqueda en la literatura científica reveló informes publicados sobre un caso de tembladera de las ovejas (scrapie o encefalopatía espongiforme ovina) en 1981 y 29 casos esporádicos de Creutzfeldt-Jakob en el país.Palabras clave: síndrome de Creutzfeldt-Jakob, priones, informes de casos.

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Section: Discussionmentioning

confidence: 99%

Positive 14-3-3 and tau proteins in a sporadic Creutzfeldt-Jakob disease case and a brief perspective of prion diseases in Colombia

Escandón-Vargas¹,

Zorrilla-Vaca²,

Corral-Prado³

2016

biomedica

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“…Сообщения в литературе о госпитальных случаях быстрого прогрессирования деменции обычно исходят из академических институтов и центров прионовых болезней. В каждом из них отмечаются особая клиническая картина, например эпистатус и быстро прогрессирующая деменция [52], развитие деменции за 5 месяцев у мужчины 66 лет и измерения в ликворе RT-QuIC (скорости конверсии белка в патологический) при отрицательном 14-3-3 и T тау-белка [53]. В другом случае быстрого прогрессирования деменции обнаружено сочетание морфологических признаков БКЯ, ДТЛ, хронической подкорковой сосудистой энцефалопатии и менингиомы [54].…”

Section: нозологические различия в скорости прогрессирования деменцииunclassified

Old Age Dementia: Clinical Patterns of Progression. Part 1

Mikhailova¹

2020

Psychiatry

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Background: the clinical experience testifies to the fact, that the increase of dementia severity in late age occurs quickly in some cases and in others it proceeds slowly, which is reflected in the total duration of the disease and survival. One of the aspects of dementias research is the study of significant differences in dementia progression rates.The objective of the review was to generalize the obtained data on progression rates of late age dementias of various genesis, first of all due to Alzheimer’s disease and its associated disorders.Material and methods: papers in MedLine/PubMed bases from1990 to 2020 were selected and analyzed according to the key words: “old age”, “dementia”, “Alzheimer’s disease”, “vascular dementia”, “progression”, “progression rate”, “disease trajectories”, as well as relevant papers in the references of the analyzed works.Conclusion: the history of research of old age dementias natural course was presented in the review of scientific publications. According to the results of development of progression rates detection methods, singling out of dementias with rapid and slow increase in the severity of cognitive decline was substantiated. Works devoted to the study of frequency and nosological belonging of dementias with different progression rates were considered. In the most recent studies prognostic models with detection of various trajectories of the course of the disease were developed. The concept of various dementias progression rates admittedly has practical meaning for provision of diagnostic and treatment assistance and planning of medical and social support measures for patients with dementia and their families. Differentiation of dementia progression clinical patterns during formation of comparable groups of patients seems appropriate for investigation of new therapy methods, as well as in clinical-biological studies of pathogenesis.

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“…Уделив специальное внимание частоте эпилептиформных расстройств при деменции, авторы признали высокую вероятность того, что эпилептическая активность частично ответственна за прогрессирование БА, предположительно, вследствие возрастания скорости отложения амилоида [57,58].…”

Section: некогнитивные (поведенческие и психопатологические) симптомыunclassified

Old Age Dementias: Factors Associated with Dementia Progression Rate. Part 2

Mikhailova¹

2020

Psychiatry

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Background: steady progression of dementia is characterized with various rates, which specified clinical differentiation of dementias with rapid and slow increase of cognitive decline severity. The search for clinical factors, hypothetically responsible for differences in late age dementia progression rate, is one of the aspects of investigation of late age dementias.The objective was to generalize the results of the study of separate clinical factors effect on the differences in the late age dementia progression rate.Material and methods: papers in MEDLINE/PubMed bases from 1990 to 2020 were selected and analyzed according to the key words: “late age”, “dementia”, “progression rate”, “age of onset”, “non-cognitive disorders”, “nosomodifying therapy”, as well as relevant papers in the literature of the analyzed works.Conclusion: various parameters of the disease were studied as associated with dementia progression pattern. As regards part of them the results achieved compliance in recognition of association with dementia progression rate. As for the others this evidence is ambiguous. There are large discrepancies in attitudes to gender differences, while early age of disease onset, initially great intensity of neuropsychiatric disorders are concordantly admitted as associated with dementia rapid progression. The researchers are united with steady idea of nonlinear character of dementia progression at the stages of mild, moderate and severe dementia.The results of study of comorbidity are basically similar with regard to recognition of SFD influence, first of all, of arterial hypertension on dementia progression rate. The evidence of the efficacy of nosomodifying therapy, decelerating dementia progression, is unanimously considered an urgent problem. The development of new dementia pathogenesis concepts and the search for new therapy targets, are conducive to the solution of this problem. The results of the investigated direction of studies confirm the hypothesis of the fact that dementia progression occurs according to various pathogenetic mechanisms, which determine the dementia increasing rate. The management of patients with dementia in practice presupposes taking into account of various factors, influencing dementia progression rate, for planning of the volume and character of medical care.

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Estatus epiléptico y demencia rápidamente progresiva en una mujer de 90 años: enfermedad de Creutzfeldt-Jakob esporádica

Cited by 3 publications

References 5 publications

Positive 14-3-3 and tau proteins in a sporadic Creutzfeldt-Jakob disease case and a brief perspective of prion diseases in Colombia

Positive 14-3-3 and tau proteins in a sporadic Creutzfeldt-Jakob disease case and a brief perspective of prion diseases in Colombia

Old Age Dementia: Clinical Patterns of Progression. Part 1

Old Age Dementias: Factors Associated with Dementia Progression Rate. Part 2

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