Estenosis duodenal secundaria a síndrome de Richter

García, Victor Arenas; Alvarez, José C.; Calderero, Francisco Xavier Cano

doi:10.1016/j.rgmx.2019.08.003

Cited by 1 publication

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“…These peptides act as classic hormones that affect tissue and organ metabolism, contributing to a decrease in insulin sensitivity of tissues and inducing inflammation [13]. On the other hand, the absence or loss of WAT that occurs through lipodystrophy and anorexiacachexia contributes to the development of hepatic steatosis and IR, since the circulating fat is deposited on the liver [14,15]. In addition, a distinct adipokine dysregulation profile appears during anorexia nervosa, following the anticipated pattern of low weight and WAT loss [16].…”

Section: Introductionmentioning

confidence: 99%

Different Effects of Low Selenite and Selenium-Nanoparticle Supplementation on Adipose Tissue Function and Insulin Secretion in Adolescent Male Rats

et al. 2022

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Adolescence is a period of intense growth and endocrine changes, and obesity and insulin-resistance processes during this period have lately been rising. Selenium (Se) homeostasis is related to lipid metabolism depending on the form and dose of Se. This study tests the actions of low-dose selenite and Se nanoparticles (SeNPs) on white (WAT) and brown adipose tissue (BAT) deposition, insulin secretion, and GPx1, IRS-1 and FOXO3a expression in the WAT of adolescent rats as regards oxidative stress, adipocyte length and adipokine secretion. Four groups of male adolescent rats were treated: control (C), low selenite supplementation (S), low SeNP supplementation (NS) and moderate SeNP supplementation (NSS). Supplementation was received orally through water intake; NS and NSS rats received two- and tenfold more Se than C animals, respectively. SeNPs were obtained by reducing Se tetrachloride in the presence of ascorbic acid. For the first time in vivo, it was demonstrated that low selenite supplementation contributed to increased adipogenesis via the insulin signaling pathway and LCN2 modulation, while low SeNP administration prevented fat depots in WAT via the decrease in insulin signaling and FOXO3a autophagy in WAT, lowering inflammation. These effects were independent of GPx1 expression or activity in WAT. These findings provide data for dietary approaches to prevent obesity and/or anorexia during adolescence. These findings may be relevant to future studies looking at a nutritional approach aimed at pre-venting obesity and/or anorexia in adolescence.

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