Esters of DL-α-tocopherol and phosphoric acid

Zhukova, E. É.; Захарова, Е. И.; Sokolova, N. A.; Sarycheva, I. K.; Evstigneeva, R. P.

doi:10.1007/bf00765776

Cited by 2 publications

(2 citation statements)

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“…1), was synthesized and tested in several experimental systems since the early 1940s [18]. After developing a novel isolation and detection method, aTP was shown only recently to occur naturally in foods and in animals as well as in human tissues [19,20].…”

Section: Introductionmentioning

confidence: 99%

α‐Tocopheryl phosphate – An active lipid mediator?

Zingg

Meydani

Azzi

2010

Molecular Nutrition Food Res

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The vitamin E (alpha-tocopherol, alphaT) derivative, alpha-tocopheryl phosphate (alphaTP), is detectable in small amounts in plasma, tissues, and cultured cells. Studies done in vitro and in vivo suggest that alphaT can become phosphorylated and alphaTP dephosphorylated, suggesting the existence of enzyme(s) with alphaT kinase or alphaTP phosphatase activity, respectively. As a supplement in animal studies, alphaTP can reach plasma concentrations similar to alphaT and only a part is dephosphorylated; thus, alphaTP may act both as pro-vitamin E, but also as phosphorylated form of vitamin E with possibly novel regulatory activities. Many effects of alphaTP have been described: in the test tube alphaTP modulates the activity of several enzymes; in cell culture alphaTP affects proliferation, apoptosis, signal transduction, and gene expression; in animal studies alphaTP prevents atherosclerosis, ischemia/reperfusion injury, and induces hippocampal long-term potentiation. At the molecular level, alphaTP may act as a cofactor for enzymes, as an active lipid mediator similar to other phosphorylated lipids, or indirectly by altering membrane characteristics such as lipid rafts, fluidity, and curvature. In this review, the molecular and cellular activities of alphaTP are examined and the possible functions of alphaTP as a natural compound, cofactor and active lipid mediator involved in signal transduction and gene expression discussed.

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Section: Introductionmentioning

confidence: 99%

α‐Tocopheryl phosphate – An active lipid mediator?

Zingg

Meydani

Azzi

2010

Molecular Nutrition Food Res

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“…The recent discovery of α-tocopherol phosphate (α-TP), a naturally occurring water-soluble form of vitamin E by Ogru et al [7] and Gianello et al [8], has raised new questions regarding whether α-TP is the mode of transport for α-T or exerts regulatory function at the cellular level? Curiously, α-TP was first synthesized and studied in the 1940's [9] but is only now being re-examined after it was found to be naturally present in low amounts in the plasma and tissues of animals and humans.…”

mentioning

confidence: 99%

Vitamin E and the Role of Water-soluble α- Tocopheryl Phosphate

Na¹

2014

Vitam Miner

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Esters of DL-α-tocopherol and phosphoric acid

Cited by 2 publications

References 5 publications

α‐Tocopheryl phosphate – An active lipid mediator?

α‐Tocopheryl phosphate – An active lipid mediator?

Vitamin E and the Role of Water-soluble α- Tocopheryl Phosphate

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