Esthesioneuroblastoma metastatic to the neck and lung: a case report and review of the literature

Sepúlveda, Ilson; Schorwer, Max; Frelinghuysen, Michael; Platín, Enrique; Delgado, Carolina; Mucientes, Francisco

doi:10.1007/s12254-015-0216-6

Cited by 2 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sites of distant metastasis reported in various large scale and single case reports are brain, spinal cord, meninges, bone, bone marrow, lung, liver, dermal, breast, heart, parotid and thyroid gland [9][10][11][12][13][14][15][16][17][18][19][20][21] and Table 1. Buohliqa et al [18] have reported three unusual recurrences, distinctly distant from the primary site, raising the questions of what constitutes real recurrence versus embolic metastasis especially around the paranasal sinuses.…”

Section: Discussionmentioning

confidence: 99%

“…During radiotherapy Mrad et al 2005 11 1 Breast 2 years Bachar et al 2008 12 3/39 Bone, lung, retroperitoneum Up to 39 months later Mattavelli et al 2009 13 1 Trachea 18 months Chew et al 2011 14 1 17 1 Neck and left lung nodule 2 years Buohliqa et al 2015 18 3/3 Maxillary sinus (2), sphenoid sinus (1) 51 months -7 years Banuchi et al 2016 19 13/57 CNS (6), bone (3), leptomeningeal (4), dermal (1) 9-134 months Hussaini et al 2016 20 1 Parotid gland 30 and 40 months Rahman M et al 2017 21 1 Thyroid gland 7 years Current study 2019 1 Submandibular gland 5 months prior to primary diagnosis…”

Section: Studymentioning

confidence: 99%

See 1 more Smart Citation

Olfactory Neuroblastoma Presenting as a Submandibular Mass

Appukutty¹

2019

AJLM

View full text Add to dashboard Cite

Background: Olfactory Neuroblastoma is a rare, locally aggressive malignant neoplasm arising from the olfactory epithelium, which causes metastasis by lymphatic and haematogenous routes, with most common site being the cervical lymph nodes. Materials and Methods: Clinical history was retrieved from discussion in the Head and Neck multidisciplinary team meeting and medical records. Routine macroscopic and microscopic histological examination along with appropriate immunohistochemistry was performed. In addition, we include the review of literature of olfactory neuroblastoma metastatic to different sites. Results: A 75 year old female presented with a left submandibular mass which on biopsy was diagnosed as high grade neuroendocrine carcinoma requiring further investigation for characterising it as primary or metastatic. The histological diagnosis proved difficult and doubtful, till after five months when on follow up investigation a skull base lesion was identified, this on biopsy was confirmed to be an olfactory neuroblastoma. Conclusion: It is important to think laterally and consider metastatic tumours when evaluating neuroendocrine lesions in the submandibular region as this can be the first manifestation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Studymentioning

confidence: 99%

Olfactory Neuroblastoma Presenting as a Submandibular Mass

Appukutty¹

2019

AJLM

View full text Add to dashboard Cite

show abstract

“…In all studies included in this review, this finding has been consistent regardless of the resection type. This finding becomes more apparent with higher disease stages as surgery followed by radiation therapy showed longer disease-free progression in Kadesh stage C in particular [25-28].…”

Section: Reviewmentioning

confidence: 99%

Esthesioneuroblastoma: Summary of Single-center Experiences with Focus on Adjuvant Therapy and Overall Survival

Alotaibi

Priola

Bernat

et al. 2019

Cureus

View full text Add to dashboard Cite

Esthesioneuroblastoma (ENB) is a rare malignant tumor of the nasal cavity. The genetic basis of its development is still under study and has not been fully delineated. It has varying symptoms depending on the lesion’s location within the nasal cavity. The most commonly used systems for such lesions are the Kadish staging and Haymes grading systems. The objectives are to review the most recent published literature evaluating the different treatments/ combination of treatment and assess the most appropriate treatment modality that can provide the longest progression-free survival and overall survival for ENB patients. Moreover, a look at what the latest literature suggests when it comes to adjuvant treatments and their effect on survival is also key to further the body of knowledge for neurosurgeons, Ears, Nose, and Throat (ENT) physicians and all the different subspecialties that deal and serve these population of patients. The published literature was reviewed starting from 1990. The focus was made on single-center experiences given their availability and easy access. The most recently published systematic review was used as the benchmark; research published after that was included in this study. The database search in OVID was conducted using the following keywords: “Esthesioneuroblastoma”, “ENB”, “Olfactory Neuroblastoma”, Nose neoplasm”, skull base neoplasm”, “radiation”, and “resection”. The database search found 17 papers which included 14 single-center reports, one systematic review, and two nationwide multi-center reviews. Surgery plus adjuvant radiation therapy appears to provide the best overall survival and progression-free survival especially in patients with high Kadesh grade. On the other hand, surgery alone or biopsy followed with radiation therapy provided the lower progression-free survival and overall survival from time of diagnosis. The role of chemotherapy, however, requires further investigation to assess its potentially harmful effects. The use of surgery as a stand-alone modality of treatment should be cautiously and rarely used in patients with lower staging scores and multiple negative resection margins.

show abstract

Esthesioneuroblastoma metastatic to the neck and lung: a case report and review of the literature

Abstract: Esthesioneuroblastoma (ENB) is a rare tumor of the olfactory epithelium that has been shown to metastasize mostly to the lymph nodes of the neck but more rarely to other locations. We report on a rare case characterized by distant metastasis to the neck and lung.

Cited by 2 publications

References 17 publications

Olfactory Neuroblastoma Presenting as a Submandibular Mass

Olfactory Neuroblastoma Presenting as a Submandibular Mass

Esthesioneuroblastoma: Summary of Single-center Experiences with Focus on Adjuvant Therapy and Overall Survival

Contact Info

Product

Resources

About