2006
DOI: 10.1186/1471-2105-7-s4-s5
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Estimate haplotype frequencies in pedigrees

Abstract: BackgroundHaplotype analysis has gained increasing attention in the context of association studies of disease genes and drug responsivities over the last years. The potential use of haplotypes has led to the initiation of the HapMap project which is to investigate haplotype patterns in the human genome in different populations. Haplotype inference and frequency estimation are essential components of this endeavour.ResultsWe present a two-stage method to estimate haplotype frequencies in pedigrees, which includ… Show more

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Cited by 5 publications
(4 citation statements)
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“…Recently, Zhang et al [8,9] proposed a haplotype frequency estimation algorithm based on trio pedigree, utilized the pedigree information and gained better performance. The haplotype frequency estimation in a general pedigree was also studied in the paper [7].…”
Section: Haplotype Frequency Estimatementioning
confidence: 99%
See 1 more Smart Citation
“…Recently, Zhang et al [8,9] proposed a haplotype frequency estimation algorithm based on trio pedigree, utilized the pedigree information and gained better performance. The haplotype frequency estimation in a general pedigree was also studied in the paper [7].…”
Section: Haplotype Frequency Estimatementioning
confidence: 99%
“…Many researchers conducted an investigation into the haplotype problem [2][3][4][5], and we also did some research work in this area [6][7][8][9]. In general, four categories of haplotype problems are widely studied: the haplotype assembly problem, the haplotype inference problem, the haplotype block partition problem and the haplotype tagging SNP selection problem.…”
Section: Introductionmentioning
confidence: 99%
“…Zhang et al [22] proposed a two-stage approach to identify haplotype frequencies in pedigrees. The two stages include the haplotyping stage and the estimation stage.…”
Section: Genetics and Population Studymentioning
confidence: 99%
“…However, the method remains impractical for large pedigrees due to mixing problems and high computational burden. Other efforts have focused on phasing tightly-linked markers in small nuclear families and moderate sized general pedigrees [ 13 - 17 ]. By focusing on markers within minimum- or zero-recombinant regions these methods reduce the complexity of the haplotype reconstruction problem.…”
Section: Introductionmentioning
confidence: 99%