Estimate of anti-SARS-CoV-2 spike IgG antibodies prevalence among Iranian population based on blood donations: A serial cross-sectional study during the third wave of the pandemic

Kermani, Fahimeh Ranjbar; Eshghi, Peyman; Arabkhazaeli, Ali; Maghsudlu, Mahtab; Kafiabad, S Amini; Teimourpour, Amir; Pourkarim, Mahmoud Reza

doi:10.1016/j.tracli.2022.09.003

Cited by 4 publications

(8 citation statements)

References 21 publications

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“…Considering that the ELISA kits used in the present study were the same as those used in the previous study, the same sensitivity (98.97%) and specificity (99.42%) were used for the adjustment of test performance (11). The Binom package was used to construct a 95% confidence interval under the asymptotic method.…”

Section: Discussionmentioning

confidence: 99%

“…Considering a 32.63% prevalence of anti-SARS-CoV-2 IgG (p) obtained from a previous study (11), a 5% alpha level (95% confidence level), a precision (d) of 0.017%, and a 15% non-participants/non-response rate, a sample size (N) of 3,697 was determined according to the following formula:…”

Section: Sample Size and Sampling Methodsmentioning

confidence: 99%

“…Previously, as a nationwide survey, the seroprevalence of SARS-CoV-2 spike IgG antibodies was determined using an enzymelinked immunosorbent assay (ELISA)-based assay on blood donors' samples. Accordingly, the seroprevalence rate of spike IgG antibodies of 32.63% (29.93% -35.33%) was reported by the end of the third week of November 2021, which coincided with the third wave of the pandemic in Iran and before the commencement of the COVID-19 vaccination program (11).…”

Section: Introductionmentioning

confidence: 99%

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Serological Profile of SARS-CoV-2 in Unvaccinated Blood Donors: A Nationwide Study During the Fifth Wave of the Pandemic in Iran

Kermani

Eshghi

Maghsudlu

et al. 2023

Jundishapur J Microbiol

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Background: Serological studies can demonstrate pathogen circulation in regional populations and reflect public health measures' effectiveness during different pandemic phases. By late November 2021, coinciding with the third pandemic wave, the seroprevalence of SARS-CoV-2 spike IgG antibodies among the Iranian population was 32.63%. Objectives: This study aimed to assess the Iranian population's seroprevalence during the fifth pandemic wave by analyzing donated blood samples. Methods: This population-based cross-sectional study was conducted on Iranian blood donors referred to all 31 main provincial capitals between August 2021 and September 2021. The participants selected through quota sampling were asked to complete a questionnaire on socio-demographics and coronavirus disease 2019 (COVID-19)-related information. Also, SARS-CoV-2 spike IgG antibodies were measured in serum samples using SARS-CoV-2 enzyme-linked immunosorbent assay (ELISA) kits. The seroprevalence was weighted based on the gender and age groups of the population and then adjusted for test performance. Results: Totally 3,339 blood donors participated in this study. The overall population-weighted seroprevalence adjusted for test performance was 52.67% (95% confidence interval (CI): 50.14 - 55.21). Seroprevalence was higher among participants with a high school diploma (55.45%, 95% CI 50.61 - 60.29), a positive history of close contact with COVID-19 patients (65.23%, 95% CI 60.83 - 69.63), and previous positive COVID-19 PCR tests (86.51%, 95% CI 82.32 - 90.7). Conclusions: More than half of the study population was exposed to SARS-CoV-2, indicating a 1.7-fold increase in the seroprevalence between late November 2020 and mid-September 2021. Our finding illuminated the pattern of Iran's fifth wave of the pandemic.

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Section: Discussionmentioning

confidence: 99%

Section: Sample Size and Sampling Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serological Profile of SARS-CoV-2 in Unvaccinated Blood Donors: A Nationwide Study During the Fifth Wave of the Pandemic in Iran

Kermani

Eshghi

Maghsudlu

et al. 2023

Jundishapur J Microbiol

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“…we would like to share ideas on the publication “Estimate of anti-SARS-CoV-2 spike IgG antibodies prevalence among Iranian population based on blood donations: A serial cross-sectional study during the third wave of the pandemic [1] ,” Ranjbar Kermani et al noted that This study showed that about one-third of the population had been infected with COVID-19. Furthermore, a significant upward trend in seroprevalence was observed.…”

mentioning

confidence: 99%

“…Furthermore, a significant upward trend in seroprevalence was observed. The predisposing factors indicate the importance of public health [1] . We agree that there should be a change in the seropeidemiology pattern when the time passes.…”

mentioning

confidence: 99%

Anti-SARS-CoV-2 spike IgG antibodies prevalence: Correspondence

Mungmunpuntipantip¹,

Wiwanitkit²

2023

Transfusion Clinique et Biologique

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Seroepidemiological assessment of SARS-CoV-2 vaccine responsiveness and associated factors in the vaccinated community of the Casablanca-Settat Region, Morocco

Ezzikouri,

Tajudeen,

Majidi

et al. 2024

Sci Rep

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Assessing the prevalence of SARS-CoV-2 IgG positivity through population-based serological surveys is crucial for monitoring COVID-19 vaccination efforts. In this study, we evaluated SARS-CoV-2 IgG positivity within a provincial cohort to understand the magnitude of the humoral response against the SARS-CoV-2 vaccine and to inform evidence-based public health decisions. A community-based cross-sectional seroprevalence study was conducted, involving 10,669 participants who received various vaccines (two doses for BBIBP-CorV/Sinopharm, Covishield vaccine, and Pfizer/BioNTech, and one dose for Johnson & Johnson's Janssen COVID-19 vaccine). The study spanned 16 provinces in the Casablanca-Settat region from February to June 2022, during which comprehensive demographic and comorbidity data were collected. We screened samples for the presence of IgG antibodies using the SARS-CoV-2 IgG II Quant assay, which quantifies antibodies against the receptor-binding domain (RBD) of the spike (S) protein, measured on the Abbott Architect i2000SR. The overall crude seroprevalence was 96% (95% CI: 95.6–96.3%), and after adjustment for assay performance, it was estimated as 96.2% (95% CI: 95.7–96.6). The adjusted overall seroprevalences according to vaccine brands showed no significant difference (96% for BBIBP-CorV/Sinopharm, 97% for ChAdOx1 nCoV-19/Oxford/AstraZeneca, 98.5% for BNT162b2/Pfizer-BioNTech, and 98% for Janssen) (p = 0.099). Participants of older age, female sex, those with a history of previous COVID-19 infection, and those with certain chronic diseases were more likely to be seropositive among ChAdOx1 nCoV-19/Oxford/AstraZeneca and BBIBP-CorV/Sinopharm vaccinee groups. Median RBD antibody concentrations were 2355 AU/mL, 3714 AU/mL, 5838 AU/mL, and 2495 AU/mL, respectively, after two doses of BBIBP-CorV/Sinopharm, ChAdOx1 nCoV-19/Oxford/AstraZeneca, BNT162b2/Pfizer-BioNTech, and after one dose of Janssen (p < 0.0001). Furthermore, we observed that participants vaccinated with ChAdOx1 nCoV-19/Oxford/AstraZeneca and BBIBP-CorV/Sinopharm with comorbid chronic diseases exhibited a more pronounced response to vaccination compared to those without comorbidities. In contrast, no significant differences were observed among Pfizer-vaccinated participants (p > 0.05). In conclusion, our serosurvey findings indicate that all four investigated vaccines provide a robust humoral immune response in the majority of participants (more than 96% of participants had antibodies against SARS-CoV-2). The BNT162b2 vaccine was found to be effective in eliciting a strong humoral response compared to the other three vaccines. However, challenges still remain in examining the dynamics and durability of immunoprotection in the Moroccan context.

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Estimate of anti-SARS-CoV-2 spike IgG antibodies prevalence among Iranian population based on blood donations: A serial cross-sectional study during the third wave of the pandemic

Cited by 4 publications

References 21 publications

Serological Profile of SARS-CoV-2 in Unvaccinated Blood Donors: A Nationwide Study During the Fifth Wave of the Pandemic in Iran

Serological Profile of SARS-CoV-2 in Unvaccinated Blood Donors: A Nationwide Study During the Fifth Wave of the Pandemic in Iran

Anti-SARS-CoV-2 spike IgG antibodies prevalence: Correspondence

Seroepidemiological assessment of SARS-CoV-2 vaccine responsiveness and associated factors in the vaccinated community of the Casablanca-Settat Region, Morocco

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