Estimate of prevalent hyperuricemia by systemic inflammation response index: results from a rural Chinese population

Chen, Meng-Qi; Wang, Haoyu; Shi, Wenrui; Sun, Yingxian

doi:10.1080/00325481.2020.1809870

Cited by 18 publications

(13 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, both NRI and IDI showed significant improvement in stratifying the risk of poor outcomes -Barcia et al, 2020). Moreover, SIRI can effectively optimize the risk stratification of hyperuricemia (Chen et al, 2021).…”

Section: Discussionmentioning

confidence: 65%

“…The low SIRI level group's overall survival time and disease progression‐free survival time were significantly better than those in the high SIRI level group (Pacheco‐Barcia et al., 2020 ). Moreover, SIRI can effectively optimize the risk stratification of hyperuricemia (Chen et al., 2021 ). The study of Chen et al.…”

Section: Discussionmentioning

confidence: 99%

“…The study of Chen et al. ( 2021 ) included 8095 patients from the Northeast China Rural Cardiovascular Health Study to detect the level of serum uric acid and analyze the relationship between SIRI and hyperuricemia. The results showed a linear relationship between SIRI and the prevalence of hyperuricemia.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic value of the systemic inflammation response index in patients with acute ischemic stroke

et al. 2022

View full text Add to dashboard Cite

Objectives Inflammation plays an essential role in acute ischemic stroke (AIS). Recent studies have recognized the systemic inflammation response index (SIRI) as a useful index to indicate inflammation status and predict the prognosis of multiple diseases. However, the relationship between SIRI and AIS prognosis is unclear. Our study is aimed to investigate the association between SIRI and the prognosis of AIS. Methods Our study prospectively recruited 287 consecutive patients with first‐ever stroke within 72 h after stroke. Demographic and clinical information was collected at baseline. The functional prognosis was assessed 3 months after AIS using the modified Rankin Scale (mRS). A poor outcome was defined as mRS > 2. SIRI was calculated as neutrophil × monocyte/lymphocyte count. Univariate and multivariate analyses were introduced to identify the association between SIRI and AIS prognosis. Receiver operating characteristic curve and reclassification analyses were used to evaluate the predictive value of SIRI for AIS prognosis. Results The patients with poor prognosis account for 27.5% of all participants. After fully adjusting for all covariates, each standard deviation increment of SIRI caused 58.9% additional risk for poor prognosis after AIS. When dividing SIRI into quartiles, the fourth quartile had a 6.152 times risk than the first quartile. Moreover, after adding SIRI into established clinical risk factors, AUC showed a significant improvement (0.829 vs. 0.790, p for comparison = .016). Consistently, category‐free net reclassification index (NRI, 0.761, 95% CI: 0.517–1.004, p < .001) and integrated discrimination index (IDI, 0.093, 95% CI: 0.0512–0.134, p < .001) confirmed the improvement by SIRI to predict poor prognosis of AIS, Conclusion SIRI is an independent prognostic indicator for AIS. Elevated SIRI is associated with poor functional outcome of AIS. Our findings suggest the usefulness of SIRI to refine the risk stratification of unfavorable prognosis of AIS.

show abstract

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic value of the systemic inflammation response index in patients with acute ischemic stroke

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Topkan et al [ 14 ] have found that SIRI could be a novel, sound, and independent predictor of survival outcomes in patients with newly diagnosed glioblastoma multiforme who underwent postoperative Stupp protocol. Chen et al [ 24 ] have demonstrated that SIRI was an effective inflammatory marker to estimate hyperuricaemia in rural Chinese women and was likely to optimise the risk stratification and prevention of hyperuricaemia. A recent study [ 25 ] has shown that SIRI was significantly higher in patients with coronavirus disease 2019 (COVID-19) than those in the control group, whereas its diagnostic value in COVID-19 was moderate.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Systemic Inflammatory Response Index for Catheter-Related Bloodstream Infection in Patients Undergoing Haemodialysis

Yang

Wang

Hua

et al. 2022

Journal of Immunology Research

View full text Add to dashboard Cite

Objective. This study was aimed at investigating the diagnostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein-to-albumin ratio (CAR), and systemic inflammatory response index (SIRI) for catheter-related bloodstream infection (CRBSI) in patients undergoing haemodialysis. Methods. A total of 296 patients undergoing haemodialysis with vascular access were selected and divided into the infected (58 patients) and uninfected (238 patients) groups. Their aetiological and general characteristics were retrospectively collected. The NLR, PLR, CAR, and SIRI were calculated. Results. The NLR, PLR, CAR, and SIRI values in the infected group were significantly higher than those in the uninfected group ( P < 0.05 ). After the anti-infective treatment, the NLR, PLR, CAR, and SIRI values in patients with CRBSI were significantly decreased ( P < 0.05 ). The NLR, CAR, and SIRI showed diagnostic efficacy in patients with CRBSI with cut-off values of 4.485 ( area under the curve AUC = 0.827 , 95 % confidence interval CI = 0.768 – 0.887 ), 0.975 ( AUC = 0.836 , 95 % CI = 0.779 – 0.892 ), and 3.390 ( AUC = 0.947 , 95 % CI = 0.919 – 0.976 ). The CAR and SIRI values in patients with gram-negative bacterial infection were significantly higher than those with gram-positive bacterial infection ( P < 0.05 ). The AUCs of CAR and SIRI were 0.693 (0.537–0.848) and 0.821 (0.700–0.942) in differentiating gram-negative and gram-positive bacterial infections, respectively. Conclusion. Our results showed SIRI as a novel and efficient indicator for the early diagnosis of CRBSI in patients undergoing haemodialysis.

show abstract

“…Recently, a novel indicator has emerged called the systemic inflammatory response index (SIRI). SIRI is a composite index based on the absolute count of three different inflammatory cells, namely, neutrophils, monocytes, and lymphocytes, and it is highly associated with cancer, hyperuricaemia, rheumatoid arthritis, and stroke [ 15–18 ]. Elevated SIRI values are related to an increased risk of myocardial infarction (MI) and overall death [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of systemic inflammatory response index in patients with acute coronary syndrome undergoing percutaneous coronary intervention

et al. 2022

View full text Add to dashboard Cite

Background The systemic inflammatory response index (SIRI) is a novel inflammatory biomarker in many diseases. Objectives The aim of this study was to examine the association between SIRI and adverse events in patients with the acute coronary syndrome (ACS) undergoing percutaneous coronary intervention. Methods A total of 1724 patients with ACS enrolled from June 2016 to November 2017 at a single centre were included in this study, and SIRI was calculated for each patient. The primary endpoint was the composite of major adverse cardiovascular events (MACE), including overall death, non-fatal myocardial infarction, non-fatal stroke, and unplanned repeat revascularization. Results During a median follow-up of 927 days, 355 patients had MACE. Multivariate Cox analysis showed that SIRI was significantly associated with MACE (hazard ratio: 1.127, 95% confidence interval: 1.034–1.229 p = .007). The results were consistent in multiple sensitivity analyses. The addition of SIRI had an incremental effect on the predictive ability of the Global Registry of Acute Coronary Events risk score for MACE (integrated discrimination improvement: 0.007, p = .040; net reclassification improvement: 0.175, p = .020; likelihood ratio test: p < .001). The restricted cubic spline showed a monotonic increase with a greater SIRI value for MACE ( p < .001). Conclusion SIRI was an independent risk factor for MACE and provided incremental prognostic information in patients with ACS undergoing percutaneous coronary intervention. KEY MESSAGES The SIRI is a strong and independent risk factor for adverse outcomes in patients with ACS undergoing percutaneous coronary intervention. Higher SIRI is associated with a more severe disease status. The SIRI could increase the prognostic value of the GRACE risk score.

show abstract

Estimate of prevalent hyperuricemia by systemic inflammation response index: results from a rural Chinese population

Cited by 18 publications

References 44 publications

Prognostic value of the systemic inflammation response index in patients with acute ischemic stroke

Prognostic value of the systemic inflammation response index in patients with acute ischemic stroke

Diagnostic Value of Systemic Inflammatory Response Index for Catheter-Related Bloodstream Infection in Patients Undergoing Haemodialysis

Prognostic value of systemic inflammatory response index in patients with acute coronary syndrome undergoing percutaneous coronary intervention

Contact Info

Product

Resources

About