Estimate of the residual risk of transfusion‐transmitted human immunodeficiency virus infection in sub‐Saharan Africa: a multinational collaborative study

Lefrère, Jean‐Jacques; Dahourouh, Honorine; Dokékias, Alexis Elira; Kouao, Maxime D; Diarra, Amadou; Diop, S.N.; Tapko, J. B.; Murphy, Edward L.; Laperche, Syria; Pillonel, Josiane

doi:10.1111/j.1537-2995.2010.02886.x

Cited by 40 publications

(46 citation statements)

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“…Pendant cette période, sept projets ont été réalisés à l'échelon national et publiés [3,[6][7][8][9][10][11] et cinq travaux multicentriques ont été conduits et publiés [12][13][14][15][16]. Seuls ces derniers sont rapportés ci-dessous.…”

Section: Travaux Réalisés Par Le Groupeunclassified

“…Dans l'étude conduite par notre groupe [14], à laquelle ont participé les services de transfusion de cinq pays d'Afrique sub-saharienne francophone, le nombre total de sujets ayant donné au moins deux fois au cours de la période d'étude était de 66 341, représentant un total de 192 109 dons de sang. Le risque résiduel du VIH a été établi en multipliant le taux d'incidence de l'infection chez les donneurs réguliers, exprimé pour 100 000 personnes-années, par la durée de la fenêtre silencieuse.…”

Section: Estimation Du Risque De Contamination Transfusionnelle Par Lunclassified

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The Francophone Africa Blood Transfusion Research Network: a five‐year report (2007–2012)

Tagny

Murphy

Lefrère

2013

Transfusion Medicine

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Peer reviewed eScholarship.org Powered by the California Digital Library University of CaliforniaThis article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. RésuméLes travaux de recherches sur la sécurité transfusionnelle en Afrique sub-saharienne sont peu nombreux, souvent limités à des initiatives locales avec des conclusions difficilement représentatives de cette région. Le Groupe de recherches transfusionnelles en Afrique sub-saharienne francophone a été créé en mai 2007 avec pour objectif de développer des stratégies globales d'amélioration de la sécurité transfusionnelle mais adaptables à la situation de chaque pays. Les activités du Groupe à ce jour ont porté essentiellement sur l'obtention de données épidémiologiques et de laboratoire sur la transfusion sanguine et à proposer des stratégies de sécurité transfusionnelle dans le domaine des infections transmissibles par la transfusion. Pour mener à bien ces activités de recherche, le Groupe travaille en étroite collaboration avec les Centres nationaux de transfusion sanguine (CNTS), les Centres régionaux de transfusion sanguine (CRTS), les banques de sang hospitalières (BSH) et les postes de collecte de sang. Pour les 5 premières années, quatre priorités de recherche ont été identifiées : (i) des études descriptives sur les caractéristiques des donneurs de sang et des centres de transfusion ; (ii) une estimation du risque résiduel post-transfusionnel des principales infections virales transmissibles par la transfusion ; (iii) une analyse des stratégies de sélection médicale des donneurs de sang ; et ( AbstractThere has been little blood safety research in sub-Saharan Africa, often consisting of local efforts whose findings had limited impact The "Francophone Africa Transfusion Research Network" was created in May 2007 with the objective of developing common evidence-based blood safety policies that may be adapted to each country's situation. The Group's activities to date have focused mainly on obtaining epidemiological and laboratory data on blood transfusion and on suggesting blood safety strategies, particularly in the field of TTIs. To carry out such research activities, the group works closely with the National Blood Transfusion Services (NBTS), the Regional Blood Transfusion Services (RBTS), the hospital blood banks (HBB) and collection stations. For the first 5 years, four research priorities were identified: (i) descriptive studies of the characteristics of francophone African blood donors and blood centers; (ii) estimation of the residual risk of transfusion-transmitted major viral infections; * Auteur correspondant. Author's personal copy 38 C.T. Tagny et al. / Transfusion Clinique et Biologique 21 (2014) 3...

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Section: Travaux Réalisés Par Le Groupeunclassified

Section: Estimation Du Risque De Contamination Transfusionnelle Par Lunclassified

The Francophone Africa Blood Transfusion Research Network: a five‐year report (2007–2012)

Tagny

Murphy

Lefrère

2013

Transfusion Medicine

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“…2 The WHO has estimated that in low-income countries the prevalence of infectious diseases such as HIV is 425 times greater than in high-income countries. 3,4,5 Testing methodologies also vary significantly between these regions. In high-income countries, almost all blood samples are tested with the highly-sensitive nucleic acid testing (NAT), 3,4,5 whereas low- and middle-income countries still rely on various serological methods and rapid tests, which are less sensitive and thus have a greater window period than NAT screening.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, most laboratories in low-income countries do not perform tests in a quality-assured manner. 3,4,5 Indeed, this has necessitated accreditation and mentoring initiatives, such as the establishment of the African Society for Laboratory Medicine in 2011. Thus, patients in low- and middle-income countries are at higher risk for transmission of infection through blood transfusion than patients in high-income countries.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, patients in low- and middle-income countries are at higher risk for transmission of infection through blood transfusion than patients in high-income countries. 3,4,5 Whilst improvements have been made in the past, a high residual risk of transfusion-transmitted infections (TTIs) remains because of viruses, bacteria, protozoa and residual contaminating leukocytes, despite decades of blood safety programmes. 3,4,5,6,7,8 …”

Section: Introductionmentioning

confidence: 99%

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Whole blood pathogen reduction technology and blood safety in sub-Saharan Africa: A systematic review with regional discussion

Nkohkwo¹,

Agbor²,

Asongalem

et al. 2016

Afr J Lab Med

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BackgroundDespite vast improvements in transfusion services in sub-Saharan Africa over the last decade, there remain serious concerns on the safety and adequacy of the blood supply across the region.ObjectiveThis review paper ascertains the role of pathogen reduction technology (PRT) in improving blood safety and supply adequacy in the region.MethodThe state of blood safety in sub-Saharan Africa was reviewed. Meetings, seminars and correspondence were undertaken with key clinicians, scientists and professional bodies in the region, including the World Health Organization’s Regional Office for Africa, to examine the suitability of PRT for improving the safety of whole blood transfusion, a prevalent transfusion format in the region.ResultsExisting literature suggests that combining PRT with current blood safety measures (such as serology) would improve the safety and adequacy of the blood supply for transfusions in sub-Saharan Africa. This was echoed by the findings of the stakeholder meetings.ConclusionFollowing a detailed appraisal of two leading PRT systems, the Mirasol® PRT System and the Cerus S-303 System, we suggest that companies conduct comprehensive toxicological evaluation of the agents used for PRT and publish this in the scientific literature. We also recommend that the safety and efficacy of these technologies should be established in a randomised clinical trial conducted in sub-Saharan Africa.

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Blood Banking Capacity in Low-and Middle-Income Countries: Covid-19 Convalescent Plasma in Context

Bloch

2024

Current Topics in Microbiology and Immunology

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Estimate of the residual risk of transfusion‐transmitted human immunodeficiency virus infection in sub‐Saharan Africa: a multinational collaborative study

Cited by 40 publications

References 30 publications

The Francophone Africa Blood Transfusion Research Network: a five‐year report (2007–2012)

The Francophone Africa Blood Transfusion Research Network: a five‐year report (2007–2012)

Whole blood pathogen reduction technology and blood safety in sub-Saharan Africa: A systematic review with regional discussion

Blood Banking Capacity in Low-and Middle-Income Countries: Covid-19 Convalescent Plasma in Context

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