In this work, we will explore the effects of non-commutativity in fractional classical and quantum schemes using the flat Friedmann–Robertson–Walker (FRW) cosmological model coupled to a scalar field in the K-essence formalism. In previous work, we have obtained the commutative solutions in both regimes in the fractional framework. Here, we introduce non-commutative variables, considering that all minisuperspace variables qnci do not commute, so the symplectic structure was modified. In the quantum regime, the probability density presents a new structure in the scalar field corresponding to the value of the non-commutative parameter, in the sense that this probability density undergoes a shift back to the direction of the scale factor, causing classical evolution to arise earlier than in the commutative world.