Estimated Breeding Values for Canine Hip Dysplasia Radiographic Traits in a Cohort of Australian German Shepherd Dogs

Wilson, Bethany; Nicholas, F. W.; James, J. W.; Wade, Claire M.; Thomson, Peter

doi:10.1371/journal.pone.0077470

Cited by 17 publications

(9 citation statements)

References 30 publications

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“…Many investigators have advocated the implementation of estimated breeding values (EBV) to accelerate progress in the selection process [ 1 , 14 – 16 , 19 , 53 , 54 , 69 – 71 ] suggesting that genomic selection would improve the response to selection up to three times more rapidly than phenotypic selection [ 72 ]. The inherent differences of response for the different breeds, would argue that the EBV breed specific approach is necessary.…”

Section: Discussionmentioning

confidence: 99%

“…Reports in the literature indicate variable response to genetic selection based upon phenotypic radiographic evidence of CHD in individual dogs (recently reviewed by [ 14 ]. Breeding schemes reliant upon phenotype have shown a modest [ 15 , 16 ] or more substantial [ 1 , 17 – 19 ] degree of improvement in hip conformation and reduced incidence CHD. Some of the variability across findings may represent differences in sample size, hip assessment protocols, preferential sire selection, and breed contribution in the study design; the latter is especially important as larger breeds are typically more prone to express these conditions due to either genetic ancestry [ 20 ] or conformational morphology [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Long-term genetic selection reduced prevalence of hip and elbow dysplasia in 60 dog breeds

Oberbauer

Famula

2017

PLoS ONE

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Canine hip dysplasia (CHD) and elbow dysplasia (ED) impact the health and welfare of all dogs. The first formally organized assessment scheme to improve canine health centered on reducing the prevalence of these orthopedic disorders. Phenotypic screening of joint conformation remains the currently available strategy for breeders to make selection decisions. The present study evaluated the efficacy of employing phenotypic selection on breed improvement of hips and elbows using the Orthopedic Foundation for Animals complete database spanning the 1970–2015 time period. Sixty breeds having more than 1000 unique hip evaluations and 500 elbow evaluations (1,056,852 and 275,129 hip and elbow records, respectively) were interrogated to derive phenotypic improvement, sex and age at time of assessment effects, correlation between the two joints, heritability estimates, estimated breeding values (EBV), and effectiveness of maternal/paternal selection. The data demonstrated that there has been overall improvement in hip and elbow conformation with a reduction in EBV for disease liability, although the breeds differed in the magnitude of the response to selection. Heritabilities also differed substantially across the breeds as did the correlation of the joints; in the absence of a universal association of these differences with breed size, popularity, or participation in screening, it appears that the breeds themselves vary in genetic control. There was subtle, though again breed specific, impact of sex and older ages on CHD and ED. There was greater paternal impact on a reduction of CHD. In the absence of direct genetic tests for either of these two diseases, phenotypic selection has proven to be effective. Furthermore, the data underscore that selection schemes must be breed specific and that it is likely the genetic profiles will be unique across the breeds for these two conditions. Despite the advances achieved with phenotypic selection, incorporation of EBVs into selection schemes should accelerate advances in hip and elbow improvement.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long-term genetic selection reduced prevalence of hip and elbow dysplasia in 60 dog breeds

Oberbauer

Famula

2017

PLoS ONE

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“…, 2015; Reist-Marti et al . , 2012; Wilson et al . , 2013), together with overall trends in genetic diversity among purebred dogs (Hayward et al .…”

Section: Introductionmentioning

confidence: 99%

Whole genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic trait mapping

Dreger

Rimbault

Davis

et al. 2016

Disease Models &Amp; Mechanisms

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In the decade following publication of the draft genome sequence of the domestic dog, extraordinary advances with application to several fields have been credited to the canine genetic system. Taking advantage of closed breeding populations and the subsequent selection for aesthetic and behavioral characteristics, researchers have leveraged the dog as an effective natural model for the study of complex traits, such as disease susceptibility, behavior and morphology, generating unique contributions to human health and biology. When designing genetic studies using purebred dogs, it is essential to consider the unique demography of each population, including estimation of effective population size and timing of population bottlenecks. The analytical design approach for genome-wide association studies (GWAS) and analysis of whole-genome sequence (WGS) experiments are inextricable from demographic data. We have performed a comprehensive study of genomic homozygosity, using high-depth WGS data for 90 individuals, and Illumina HD SNP data from 800 individuals representing 80 breeds. These data were coupled with extensive pedigree data analyses for 11 breeds that, together, allowed us to compute breed structure, demography, and molecular measures of genome diversity. Our comparative analyses characterize the extent, formation and implication of breed-specific diversity as it relates to population structure. These data demonstrate the relationship between breed-specific genome dynamics and population architecture, and provide important considerations influencing the technological and cohort design of association and other genomic studies.

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“…Current breeding programmes against the disease are voluntary and recommend breeding from animals with HS (or equivalent) below a given threshold. They have resulted in measurable but moderate success [ 7 – 10 ]. Approaches that could enhance the performance of these programmes include selection based on phenotype-derived estimated breeding values (EBVs) [ 9 – 11 ] and/or marker-assisted or genomic selection [ 12 , 13 ], where specific markers associated with the disease or genome-wide markers, respectively, are incorporated into breeding values.…”

Section: Introductionmentioning

confidence: 99%

Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers

et al. 2014

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BackgroundCanine hip dysplasia (CHD) is characterised by a malformation of the hip joint, leading to osteoarthritis and lameness. Current breeding schemes against CHD have resulted in measurable but moderate responses. The application of marker-assisted selection, incorporating specific markers associated with the disease, or genomic selection, incorporating genome-wide markers, has the potential to dramatically improve results of breeding schemes. Our aims were to identify regions associated with hip dysplasia or its related traits using genome and chromosome-wide analysis, study the linkage disequilibrium (LD) in these regions and provide plausible gene candidates. This study is focused on the UK Labrador Retriever population, which has a high prevalence of the disease and participates in a recording program led by the British Veterinary Association (BVA) and The Kennel Club (KC).ResultsTwo genome-wide and several chromosome-wide QTLs affecting CHD and its related traits were identified, indicating regions related to hip dysplasia.ConclusionConsistent with previous studies, the genetic architecture of CHD appears to be based on many genes with small or moderate effect, suggesting that genomic selection rather than marker-assisted selection may be an appropriate strategy for reducing this disease.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2164-15-833) contains supplementary material, which is available to authorized users.

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Estimated Breeding Values for Canine Hip Dysplasia Radiographic Traits in a Cohort of Australian German Shepherd Dogs

Cited by 17 publications

References 30 publications

Long-term genetic selection reduced prevalence of hip and elbow dysplasia in 60 dog breeds

Long-term genetic selection reduced prevalence of hip and elbow dysplasia in 60 dog breeds

Whole genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic trait mapping

Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers

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