Estimated incidence of juvenile-onset recurrent respiratory papillomatosis in Korea

Abstract

Objective: Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 and 11 and is potentially preventable through vaccination. This study estimated incidence of juvenile-onset RRP before the implementation of the national HPV vaccination program in South Korea. Methods: We conducted a cohort study using claims data provided by a mandatory insurance program to estimate the incidence of RRP and associated healthcare use. Patients with juvenile RRP were defined as those aged ≤12 years with ≥2 admission or ≥2 outpatient visits during which they received the International Classification of Diseases code of benign neoplasms of the larynx (D14.1). Results: During 2002-2014, 123 children (74 boys and 49 girls) were diagnosed with RRP. The patients had a mean of 6.5 person-years of follow-up. The incidence was estimated at 0.30/100,000 person-year. The median age at diagnosis was 4 (mean, 4.3) years. Thirty-six (29.3%) patients underwent surgery, including 23 patients (18.7%) who underwent 2 or more surgeries. Severe disease, measured by more frequent surgeries and shorter time intervals between consecutive surgeries, was associated with a younger age at diagnosis. Conclusion: The estimated incidence of juvenile-onset RRP in South Korea was similar to that reported in other countries. The RRP burden should continue to be monitored using the National Health Insurance Service claims data.

Prevalence and Etiological Structure of Recurrent Respiratory Papillomatosis in Children and Adults: Actual Data

“…Тем не менее, в других странах аналогичные исследования представлены в достаточном количестве. Так, в Южной Корее распространенность РРП составляет 0,30 на 100 000 человек среди лиц в возрасте младше 12 лет [14]. Этот уровень сопоставим с данными, регистрируемыми в других странах для аналогичной возрастной группы.…”

“…Однако данные, подтверждающие это, противоречивы и ограничены [32]. В одном из исследований было показало, что у пациентов с ВПЧ11 период между операциями был гораздо короче по сравнению с ВПЧ6, но эта корреляция прослеживалась только при ЮРРП, но не при РРП у взрослых [14]. Возможно, эти противоречия связаны с разной методологией проведенных исследований.…”