Estimated morbidity and mortality in adolescents and young adults diagnosed with Type 2 diabetes mellitus

Rhodes, ET; Prosser, LA; Hoerger, Thomas J.; Lieu, Tracy A.; Ludwig, David S.; Lm, Laffel

doi:10.1111/j.1464-5491.2011.03542.x

Cited by 137 publications

(92 citation statements)

References 40 publications

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“…Therefore, we believe that the more likely explanation is that young-onset type 2 diabetes represents a more severe form of diabetes. Our data support recently published studies suggesting that young-onset type 2 diabetes is the more lethal phenotype of diabetes and is associated with a greater mortality, more diabetes complications, unfavorable CVD risk factors, and greater difficulty in achieving glycemic control, even compared with type 1 diabetes (33)(34)(35)(36). Given the increasing incidence of young-onset type 2 diabetes and its severity, there is an urgent need for diabetes prevention efforts to be targeted toward youth.…”

Section: Comparison With the Literaturesupporting

confidence: 80%

Age-Specific Trends From 2000–2011 in All-Cause and Cause-Specific Mortality in Type 1 and Type 2 Diabetes: A Cohort Study of More Than One Million People

et al. 2016

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OBJECTIVETo analyze changes by age-group in all-cause and cause-specific mortality rates from 2000-2011 in people with diabetes. RESEARCH DESIGN AND METHODSA total of 1,189,079 (7.3% with type 1 diabetes) Australians with diabetes registered on the National Diabetes Service Scheme between 2000 and 2011 were linked to the National Death Index. Mortality rates in the total population were age standardized to the 2001 Australian population. Mortality rates were calculated for the following age-groups: 0 to <40 years, ‡ 40 to <60 years, and ‡60 to £85 years. Annual mortality rates were fitted using a Poisson regression model including calendar year as a covariate and age and sex where appropriate, with P trend reported. RESULTSFor type 1 diabetes, all-cause, cardiovascular disease (CVD), and diabetes agestandardized mortality rates (ASMRs) decreased each year by 0.61, 0.35, and 0.14 per 1,000 person-years (PY), respectively, between 2000 and 2011, P trend < 0.05, while cancer mortality remained unchanged. By age, significant decreases in allcause, CVD, and diabetes mortality rates were observed in all age-groups, excluding diabetes mortality in age-group 0-40 years. For type 2 diabetes, all-cause, CVD, and diabetes ASMRs decreased per year by 0.18, 0.15, and 0.03 per 1,000 PY, respectively, P trend < 0.001, while cancer remained unchanged. By age, these decreases were observed in all age-groups, excluding 0-40 years, where significant increases in all-cause and cancer mortality were noted and no change was seen for CVD and diabetes mortality. CONCLUSIONSAll-cause, CVD, and diabetes ASMRs in type 1 and type 2 diabetes decreased between 2000 and 2011, while cancer ASMRs remained unchanged. However, younger populations are not benefiting from the same improvements as older populations. In addition, the absence of a decline in cancer mortality warrants urgent attention.

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Section: Comparison With the Literaturesupporting

confidence: 80%

Age-Specific Trends From 2000–2011 in All-Cause and Cause-Specific Mortality in Type 1 and Type 2 Diabetes: A Cohort Study of More Than One Million People

et al. 2016

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“…The cardiac consequences of diabetes, particularly diastolic dysfunction and left ventricular stiffness (18,19) are associated with diabetes duration, due to the progressive accumulation of permanent advanced glycation end products (20,21), and possibly cardiac steatosis and increased left ventricular free fatty acid metabolism (22). It is therefore hypothesized that early interventions may prevent or delay changes in cardiac function and reduce the elevated risk of developing microvascular and macrovascular morbidity in adolescents with diabetes (21,23).…”

mentioning

confidence: 99%

“…It is therefore hypothesized that early interventions may prevent or delay changes in cardiac function and reduce the elevated risk of developing microvascular and macrovascular morbidity in adolescents with diabetes (21,23). However, adolescents with T2DM also have reduced cardiovascular capacity (24,25), and, thus, preventing diabetes-related complications depends on the assumption that either the cardiovascular consequences of diabetes are not evident in early-stage diabetes or early changes in cardiac function can be reversed.…”

mentioning

confidence: 99%

Systolic and Diastolic Abnormalities Reduce the Cardiac Response to Exercise in Adolescents With Type 2 Diabetes

et al. 2014

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OBJECTIVETo better understand the cardiac limitations during exercise in adolescents with type 2 diabetes mellitus (T2DM), we measured left ventricular performance with magnetic resonance imaging (MRI) during exercise in diabetic and nondiabetic adolescents. RESEARCH DESIGN AND METHODSThirteen subjects with T2DM, 27 overweight/obese nondiabetic (ObeseND) subjects, and 19 nondiabetic nonobese control subjects were recruited. Cardiac (left ventricular) MRI scans were performed at rest and during submaximal exercise. RESULTSVO 2 peak indexed to fat-free mass was reduced in T2DM and ObeseND subjects compared with control subjects (P < 0.0001). Indexed cardiac output increased less during exercise and was 20% lower in T2DM subjects due to reduced stroke volume. This was a consequence of reduced ventricular filling with smaller enddiastolic volume, which decreased further during exercise in T2DM subjects, but not in ObeseND or control subjects. End-systolic volume was also smaller in T2DM subjects. These changes were associated with increased resting and exercise diastolic blood pressure, and total peripheral resistance in T2DM subjects. CONCLUSIONSIndependently of obesity, T2DM impairs cardiac function during exercise in adolescents. Diabetes Care 2014;37:143937: -144637: | DOI: 10.233737: /dc13-2031 Exercise is a standard recommendation in the management and prevention of type 2 diabetes mellitus (T2DM) (1,2). Regrettably, people with diabetes often have reduced cardiac reserve (3,4) and a resultant decrease in aerobic capacity (3,5). Adults with T2DM have smaller left ventricular stroke volume (6) and reduced heart rates (3,7) during peak exercise. These factors may present a barrier to exercise participation because recommended "moderate intensity" exercise (2) requires a greater proportion of their aerobic capacity (8).Several authors suggest that reduced early left ventricular diastolic filling (i.e., diastolic dysfunction) is responsible for lower aerobic capacity in people with T2DM,

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“…При ЦД практично вдвічі підвищується ризик смерті від серцево-судинних захворювань і гострого порушення мозкового кровообігу [6,7]. Одним із основних шляхів контролю ЦД є призначен-ня ефективної цукрознижувальної терапії в комбінації з препаратами, що виявляють широ-кий метаболічний та імунокорегуючий спектр дії, зокрема вітаміну D 3 [8].…”

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Correction by vitamin D(3) of disturbed metabolism in patients with diabetes mellitus types 1 and 2

Komisarenko¹

2014

Ukr.Biochem.J.

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Estimated morbidity and mortality in adolescents and young adults diagnosed with Type 2 diabetes mellitus

Cited by 137 publications

References 40 publications

Age-Specific Trends From 2000–2011 in All-Cause and Cause-Specific Mortality in Type 1 and Type 2 Diabetes: A Cohort Study of More Than One Million People

Age-Specific Trends From 2000–2011 in All-Cause and Cause-Specific Mortality in Type 1 and Type 2 Diabetes: A Cohort Study of More Than One Million People

Systolic and Diastolic Abnormalities Reduce the Cardiac Response to Exercise in Adolescents With Type 2 Diabetes

Correction by vitamin D(3) of disturbed metabolism in patients with diabetes mellitus types 1 and 2

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