Estimated plasma volume and mortality: analysis from NHANES 1999–2014

Marawan, Amr; Qayyum, Rehan

doi:10.1007/s00392-020-01606-z

Cited by 8 publications

(8 citation statements)

References 35 publications

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“…The Duarte ePVS provides a method that instantaneously estimate the plasma status [9]. In the largest study to date (data from the NHANS database, involving 42705 participants from 1999-2014), the mean ePVS in the general population was 4.2 ± 0.84 mL/g [10]. Another study recruited 1747 patients diagnosed with HF with preserved ejection fraction and found that the mean ePVS was 4.9 ± 1.0 mL/g [21].…”

Section: Discussionmentioning

confidence: 99%

“…Studies found that some indicators reflecting patients' demographic, hemodynamic, and metabolic profiles may predict the risk of postoperative hypotension, and hypotension can be subcategorized as cardiogenic or hypovolemic in most cases [7,8]. The estimated plasma volume status (ePVS) estimated by the Duarte formula which assesses the volume overload and reflects the prognosis at a very low cost, has proven to be associated with clinical outcomes in patients with heart failure (HF) [9][10][11]. Several reports assessed the correlation between ePVS and actual plasma volume measured using conventional radioisotope-labeled albumin or red blood cell assays and found that the ePVS derived from the formulas and actual plasma volume using the gold standard method showed a moderate-to-strong correlation [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Predictive value of estimated plasma volume for postoperative hypotension in percutaneous intramyocardial septal radiofrequency ablation treating for hypertrophic obstructive cardiomyopathy

Shan,

Li,

Shi

et al. 2024

BMC Cardiovasc Disord

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Background Estimated plasma volume status (ePVS) estimated by the Duarte formula is associated with clinical outcomes in patients with heart failure. It remains unclear the predictive value of the ePVS to the postoperative hypotension (POH) in percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) treating hypertrophic obstructive cardiomyopathy (HOCM). Methods Data of HOCM patients who underwent PIMSRA were retrospectively collected. Preoperative ePVS was calculated using the Duarte formulas which derived from hemoglobin and hematocrit ratios. Clinical variables including physical assessment, biological and echocardiographic parameters were recorded. Patients were labeled with or without POH according to the medical record in the hospital. Univariable and multivariable logistic regression were performed to evaluate the association between ePVS and POH. Using different thresholds derived from quartiles and the best cutoff value of the receiver operating characteristic curve, the diagnostic performance of ePVS was quantified. Results Among the 405 patients included in this study, 53 (13.1%) patients were observed with symptomatic POH. Median (IQR) of ePVS in overall patients was 3.77 (3.27~4.40) mL/g and in patients with POH were higher than those without POH. The ePVS was associated with POH, with the odds ratio of 1.669 (95% CI 1.299 ~ 2.144) per mL/g. After adjusted by potential confounders, ePVS remained independently associated with POH, with the approximate odds ratio in different models. Conclusion The preoperative ePVS derived from the Duarte formulas was independently associated with postoperative hypotension in HOCM patients who underwent PIMSRA and showed prognostic value to the risk stratification of postoperative management. Trial registration NCT06003478 (22/08/2023).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Predictive value of estimated plasma volume for postoperative hypotension in percutaneous intramyocardial septal radiofrequency ablation treating for hypertrophic obstructive cardiomyopathy

Shan,

Li,

Shi

et al. 2024

BMC Cardiovasc Disord

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“…Recently, the PARADISE registry study, which enrolled 1369 patients admitted for acute dyspnoea in the emergency department, found that ePVS values greater than 5.12 mL/g presented an adjusted odds ratio of 1.47 (95% CI 1.04-2.09, P = 0.029) for in-hospital mortality [22]. Marawan et al [30] study showed that high ePVS was associated with an increased risk of all-cause death, with a hazard ratio of 1.29 (95% CI 1.24-1.25, P < 0.001), this results was similar to our findings. In our study, the higher-level of ePVS patients gained higher SAPSII (32.95 ± 0.56 vs. 26.00 ± 0.49, P < 0.001) and SOFA score (4.01 ± 0.10 vs. 2.13 ± 0.10, P < 0.001) compared with lower-level of ePVS ones.…”

Section: Discussionmentioning

confidence: 99%

Estimated plasma volume status (ePVS) is a predictor for acute myocardial infarction in-hospital mortality: analysis based on MIMIC-III database

Shen

Cai

Wei

et al. 2021

BMC Cardiovasc Disord

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Background Estimated plasma volume status (ePVS) has been reported that associated with poor prognosis in heart failure patients. However, no researchinvestigated the association of ePVS and prognosis in patients with acute myocardial infarction (AMI). Therefore, we aimed to determine the association between ePVS and in-hospital mortality in AMI patients. Methods and results We extracted AMI patients data from MIMIC-III database. A generalized additive model and logistic regression model were used to demonstrate the association between ePVS levels and in-hospital mortality in AMI patients. Kaplan–Meier survival analysis was used to pooled the in-hospital mortality between the various group. ROC curve analysis were used to assessed the discrimination of ePVS for predicting in-hospital mortality. 1534 eligible subjects (1004 males and 530 females) with an average age of 67.36 ± 0.36 years old were included in our study finally. 136 patients (73 males and 63 females) died in hospital, with the prevalence of in-hospital mortality was 8.9%. The result of the Kaplan–Meier analysis showed that the high-ePVS group (ePVS ≥ 5.28 mL/g) had significant lower survival possibility in-hospital admission compared with the low-ePVS group (ePVS < 5.28 mL/g). In the unadjusted model, high-level of ePVS was associated with higher OR (1.09; 95% CI 1.06–1.12; P < 0.001) compared with low-level of ePVS. After adjusted the vital signs data, laboratory data, and treatment, high-level of ePVS were also associated with increased OR of in-hospital mortality, 1.06 (95% CI 1.03–1.09; P < 0.001), 1.05 (95% CI 1.01–1.08; P = 0.009), 1.04 (95% CI 1.01–1.07; P = 0.023), respectively. The ROC curve indicated that ePVS has acceptable discrimination for predicting in-hospital mortality. The AUC value was found to be 0.667 (95% CI 0.653–0.681). Conclusion Higher ePVS values, calculated simply from Duarte’s formula (based on hemoglobin/hematocrit) was associated with poor prognosis in AMI patients. EPVS is a predictor for predicting in-hospital mortality of AMI, and could help refine risk stratification.

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“…Increasing DPVS is associated with higher risk of adverse outcome in patients with other conditions that are not associated with plasma volume expansion, such as cancer [31], or sepsis [32], suggesting that DPVS is not a surrogate measure of congestion, but a complicated way to apply measurements of haemoglobin.…”

Section: Dpvsmentioning

confidence: 99%

Are non-invasive estimations of plasma volume an accurate measure of congestion in patients with chronic heart failure?

Cuthbert

Pellicori

Rigby

et al. 2022

European Heart Journal - Quality of Care and Clinical Outcomes

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Aim We report associations between different formulae for estimating plasma volume status (PVS) and clinical and ultrasound markers of congestion in patients with chronic heart failure (CHF) enrolled in the Hull Lifelab registry. Methods and results Cohort 1 comprised patients with data on signs and symptoms at initial evaluation (n = 3505). Cohort 2 included patients with ultrasound assessment of congestion (lung B-line count, inferior vena cava (IVC) diameter, jugular vein distensibility (JVD) ratio) (N = 341). Two formulae for PVS were used: (a) Hakim (HPVS) and (b) Duarte (DPVS). Results were compared with clinical and ultrasound markers of congestion. Outcomes assessed were mortality and the composite of heart failure (HF) hospitalisation and all-cause mortality. In cohort 1, HPVS was associated with mortality (hazard ratio (HR) per unitary increase = 1.02 (1.01 – 1.03); P<0.001). In cohort 2, HPVS was associated with B-line count (HR) = 1.05 (95% confidence interval (CI) 1.01 – 1.08); P = 0.02) and DPVS with the composite outcome (HR = 1.26 (1.01 – 1.58); P = 0.04). HPVS and DPVS were strongly related to haemoglobin concentration and HPVS to weight. After multivariable analysis, there were no strong or consistent associations between PVS and measures of congestion, severity of symptoms, or outcome. By contrast, log[NTproBNP] was strongly associated with all three. Conclusions Amongst patients with CHF, HPVS and DPVS are not strongly or consistently associated with clinical or ultrasound evidence of congestion, nor clinical outcomes after multivariable adjustment. They appear only to be surrogates of the variables from which they are calculated with no intrinsic clinical utility.

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Estimated plasma volume and mortality: analysis from NHANES 1999–2014

Cited by 8 publications

References 35 publications

Predictive value of estimated plasma volume for postoperative hypotension in percutaneous intramyocardial septal radiofrequency ablation treating for hypertrophic obstructive cardiomyopathy

Predictive value of estimated plasma volume for postoperative hypotension in percutaneous intramyocardial septal radiofrequency ablation treating for hypertrophic obstructive cardiomyopathy

Estimated plasma volume status (ePVS) is a predictor for acute myocardial infarction in-hospital mortality: analysis based on MIMIC-III database

Are non-invasive estimations of plasma volume an accurate measure of congestion in patients with chronic heart failure?

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