We investigate an Lq(Lp)-regularity (1 < p, q < ∞) theory for space-time nonlocal equations with zero initial conditionHere, ∂ α t is the Caputo fractional derivative of order α ∈ (0, 1) and L is an integro-differential operator|y|)dy 2020 Mathematics Subject Classification. 35B65, 26A33, 47G20.