Estimates of genomic heritability and genome-wide association studies for blood parameters in Akkaraman sheep

Arzık, Yunus; Kızılaslan, Mehmet; White, Stephen N.; Piel, Lindsay M. W.; Çınar, Mehmet Ulaş

doi:10.1038/s41598-022-22966-8

Cited by 9 publications

(7 citation statements)

References 54 publications

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“…At 18 months of age, approximately 78 of these female animals had a second fleece sampling, which was additionally weighed for greasy fleece (an example of Akkaraman wool presented as Supplementary Figure S2 ). Further information on the climatic and geographic conditions of the region, herd management, mating, selection strategy and feeding practices were presented in detail previously [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

“…Reference genomes have been published for domestic sheep and high density commercial arrays have been developed for genome-wide distributed single nucleotide polymorphisms (SNPs), which can be employed to map the relationship between economically important traits and genomic loci [ 19 ]. Genomic data have been used effectively in many studies to discover SNPs, major variants, genes and quantitative trait loci (QTLs) associated with traits in farm animals [ 20 , 21 , 22 , 23 , 24 , 25 ]. The information obtained from these studies can be incorporated into systematic breeding programmes to achieve rapid genetic improvement of the studied traits [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Genome-Wide Scan of Wool Production Traits in Akkaraman Sheep

Arzık

Kızılaslan

Behrem

et al. 2023

Genes

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The objective of this study was to uncover the genetic background of wool quality, a production trait, by estimating genomic heritability and implementing GWAS in Akkaraman sheep. The wool characteristics measured included fibre diameter (FD) and staple length (SL) at the age of 8 months and yearling fibre diameter (YFD), yearling staple length (YSL) and yearling greasy fleece weight (YGFW) at 18 months of age. Animals were genotyped using the Axiom 50 K Ovine Genotyping Array. Maximum likelihood estimations of a linear mixed model (LMM) were used to estimate genomic heritability, where GWAS was conducted following a score test of each trait. Genomic heritability estimates for the traits ranged between 0.22 and 0.63, indicating that phenotypes have a moderate range of heritability. One genome- and six chromosome-wide significant SNPs were associated with the wool traits in Akkaraman lambs. Accordingly, TRIM2, MND1, TLR2, RNF175, CEP290, TMTC3, RERE, SLC45A1, SOX2, MORN1, SKI, FAAP20, PRKCZ, GABRD, CFAP74, CALML6 and TMEM52 genes as well as nine uncharacterized regions (LOC101118971, LOC105609137, LOC105603067, LOC101122892, LOC106991694, LOC106991467, LOC106991455, LOC105616534 and LOC105609719) were defined as plausible candidates. The findings of this study shed light on the genetics of wool quality and yield for the Akkaraman breed and suggests targets for breeders during systematic breeding programmes.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genome-Wide Scan of Wool Production Traits in Akkaraman Sheep

Arzık

Kızılaslan

Behrem

et al. 2023

Genes

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“…It has been reported that 45% of domestic sheep in Türkiye are Akkaraman ( Ozmen et al, 2020 ). They are known for their adaptability to arid environments, cold resilience, disease resistance or tolerance, and ability to thrive on low-quality pastures ( Arzik et al, 2022a ). The Karakas in Eastern Anatolia, Kangal in Central Anatolia, Savak in Eastern Anatolia, Guney Karaman in the Mediterranean, and Norduz in the Eastern Anatolian regions are recognized as varieties/subtypes of the Akkaraman ( Ozmen et al, 2020 ).…”

Section: Sheep Breeds In Türkiyementioning

confidence: 99%

Review of sheep breeding and genetic research in Türkiye

Aydin,

Bi,

Brito

et al. 2024

Front. Genet.

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The livestock industry in Türkiye is vital to the country’s agricultural sector and economy. In particular, sheep products are an important source of income and livelihood for many Turkish smallholder farmers in semi-arid and highland areas. Türkiye is one of the largest sheep producers in the world and its sheep production system is heavily dependent on indigenous breeds. Given the importance of the sheep industry in Türkiye, a systematic literature review on sheep breeding and genetic improvement in the country is needed for the development and optimization of sheep breeding programs using modern approaches, such as genomic selection. Therefore, we conducted a comprehensive literature review on the current characteristics of sheep populations and farms based on the most up-to-date census data and breeding and genetic studies obtained from scientific articles. The number of sheep has increased in recent years, mainly due to the state’s policy of supporting livestock farming and the increase in consumer demand for sheep dairy products with high nutritional and health benefits. Most of the genetic studies on indigenous Turkish sheep have been limited to specific traits and breeds. The use of genomics was found to be incipient, with genomic analysis applied to only two major breeds for heritability or genome-wide association studies. The scope of heritability and genome-wide association studies should be expanded to include traits and breeds that have received little or no attention. It is also worth revisiting genetic diversity studies using genome-wide single nucleotide polymorphism markers. Although there was no report of genomic selection in Turkish sheep to date, genomics could contribute to overcoming the difficulties of implementing traditional pedigree-based breeding programs that require accurate pedigree recording. As indigenous sheep breeds are better adapted to the local environmental conditions, the proper use of breeding strategies will contribute to increased income, food security, and reduced environmental footprint in a sustainable manner.

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“…Since both the number of goats and the number of other domestic breeds are not competitive compared to the world-wide breeds in terms of production, their numbers are decreasing day by day. Although studies have been carried out to identify the genetic potential of domestic animal genetic resources in terms of economically important traits, these studies are not yet sufficient in Türkiye (Gül et al, 2020;Behrem, 2021;Kizilaslan et al, 2022;Arzik et al, 2022;Yilmaz et al, 2022). There are similar situations in Angora goats, and unfortunately their number has experienced a serious decline for a period.…”

Section: Introductionmentioning

confidence: 99%

Economic Evaluation of Mohair Production in Ankara Province

Arzık

Behrem

Kızılaslan³

2023

Black Sea Journal of Agriculture

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Angora goat is the most important goat breed that spread from Central Asia to Anatolia and became a part of Turkish culture. Angora goat, which is thought to have been brought to Anatolia in the 13th century, is intensively raised in the Central Anatolian region, especially in Ankara and its surroundings. In this study, it is aimed to give information about the distribution of the goat population according to Ankara province and its districts, the amount and price of mohair purchase by years, and the fiber quality of Angora goats raised in the region. According to the findings, it has been observed that there is an increase in the number of Angora goats in Ankara parallel with the total number of small ruminant in Turkey. When the farms that are members of Ankara Sheep and Goat Breeders' Association are examined, Ankara goat breeding is carried out in almost all districts of Ankara. Furthermore, when mohair prices are analyzed in dollars, it is determined that the highest price was in 2019, and the amount of subsidy given by the State decreased over the years. In terms of literature, we can say that there are not enough new studies on Angora goats and that up-to-date studies are needed. The fact that Ankara is suitable for goat breeding due to its geography and that goat breeding is important for those living in rural areas in cultural terms has ensured the continuity of Ankara Goat production. Although the goat population seems to be increasing in the last 10 years, there has been a serious decrease compared to the beginning of the 1900s. Necessary studies should be done properly in order to increase the Angora goat population

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Estimates of genomic heritability and genome-wide association studies for blood parameters in Akkaraman sheep

Cited by 9 publications

References 54 publications

Genome-Wide Scan of Wool Production Traits in Akkaraman Sheep

Genome-Wide Scan of Wool Production Traits in Akkaraman Sheep

Review of sheep breeding and genetic research in Türkiye

Economic Evaluation of Mohair Production in Ankara Province

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