Estimates of heritabilities and genetic correlations of growth and external skeletal deformities at different ages in a reared gilthead sea bream (Sparus aurata L.) population sourced from three broodstocks along the Spanish coasts

García-Celdrán, M.; Ramis, G.; Manchado, Manuel; Estévez, Alicia; Afonso, Juan Manuel; María-Dolores, Emilio; Peñalver, J.; Armero, Eva

doi:10.1016/j.aquaculture.2015.04.006

Cited by 30 publications

(20 citation statements)

References 44 publications

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“…Previous studies in fish demonstrated that heritabilities for disease resistance traits oscillate from moderate to high, and hence they can be incorporated to breeding programs to minimize fish losses and enhance fish welfare [22]. In sea bream, genetic selection programs have focused mainly on growth, morphology and carcass quality traits [16][17][18]23]. To date, only heritabilities for fish survival after challenging with the pathogenic bacteria P. damselae subsp.…”

Section: Discussionmentioning

confidence: 99%

“…LCDV outbreaks are recurrently observed every year and, occasionally, associated with high mortalities [3,15]. Currently, most ongoing genetic programs for this species are mostly focused on the improvement of growth, morphology and carcass quality [16][17][18][19]. Genetic estimates for disease resistance were only reported for the bacterial pathogen Photobacterium damselae subsp.…”

Section: Introductionmentioning

confidence: 99%

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Heritability Estimates and Genetic Correlation for Growth Traits and LCDV Susceptibility in Gilthead Sea Bream (Sparus aurata)

Carballo

Shin

Berbel

et al. 2019

Fishes

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The lymphocystis disease (LCD) is a viral infection with a high economic impact in gilthead sea bream aquaculture. In this study, genetic estimates associated with lymphocystis disease virus (LCDV) disease susceptibility and growth were determined in sea bream juveniles. Two fish batches (named batch 1 and batch 2) were built from mass spawning and reared under industrial conditions until disease outbreak. At the moment of the sampling (n = 500 specimens for each batch), all animals had the typical LCDV lesions in the skin. For phenotyping, animals were weighted and photographed for image analysis (surface covered and lesion intensity). LCDV DNA copies were quantified in the liver by qPCR. Batch 1 had a higher surface covered and lesion intensity than batch 2, and the body caudal region was the lowest affected region in both batches. The average LCDV DNA copies in liver were higher in the batch 1 than batch 2, and they were positively correlated with severity index (SI) categories (r2 = 0.90–0.94). The total number of families evaluated were 150 and 128 for batch 1 and batch 2, respectively, with a high bias in offspring contribution by family and broodstock. Heritabilities for weight and length were 0.18 and 0.14 in batch 1 and 0.06 and 0.05 in batch 2, respectively. Heritability for the number of viral DNA copies was low (<0.08) in both batches. Heritabilities for SI in binary scale were 0.32/0.33 and 0.21/0.24 (underlying liability/Bayesian approach) for batch 1 and batch 2, respectively. Genetic correlations were very high and positive when growth traits (weight and length) or disease traits (LCDV DNA copies and SI) were compared. In contrast, the genetic correlations between growth and disease traits were moderate–high and positive in the batch 1 but negative in batch 2. These results indicate the genetic selection for LCDV susceptibility and growth is feasible in sea bream juveniles, although estimates are highly dependent on the age. The information provided is relevant to designing selective breeding programs in sea bream.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Heritability Estimates and Genetic Correlation for Growth Traits and LCDV Susceptibility in Gilthead Sea Bream (Sparus aurata)

Carballo

Shin

Berbel

et al. 2019

Fishes

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“…In gilthead sea bream, development of the LSK syndrome has been associated with family structure (Afonso et al, ), and consanguinity has been shown to increase the incidence of LD and lack of an OPC, having both characters high heritability (Afonso et al, ; Navarro et al, ). More recently, García‐Celdrán et al () and Negrín‐Báez et al () also reported a significant relationship between the prevalence of LD, LSK and lack of OPC and the mating of broodstock of different origins suffering from the same deformity, thus confirming the importance of inheritance in the presence of these malformations in gilthead sea bream.…”

Section: Introductionmentioning

confidence: 84%

“…Development of skeletal anomalies is a complex process that may be explained not only in terms of gene transcription alteration, but also due to other types of factors, which can also interact with each other. In fact, although in gilthead sea bream, skeletal deformities, such as LD, LSK, lack of OPC or vertebral fusion, have been related to genetic components and inheritance (García‐Celdrán et al, ; Navarro et al, ; Negrín‐Báez et al, ), some other authors have proved that rearing conditions, stress or inadequate feeding can also be leading to deformities in skeletal structures (Koumoundouros, Oran, Divanach, Stefanakis, & Kentouri, ; Prestinicola et al, ). In this sense, Prestinicola et al () demonstrated that it is possible to lower the severe skeletal anomaly incidence and the meristic count variability of dermal bones of reared gilthead sea bream juveniles by lowering stocking densities.…”

Section: Discussionmentioning

confidence: 99%

Gene expression analyses in malformed skeletal structures of gilthead sea bream (Sparus aurata)

Riera‐Heredia

Vélez

Gutiérrez

et al. 2019

Journal of Fish Diseases

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The incidence of skeletal anomalies in reared fish has been translated for years in important economic losses for the aquaculture industry. In the present study, we have analysed the gene expression of extracellular matrix components and transcription factors involved in bone development in gilthead sea bream presenting different skeletal anomalies: lordosis (LD), lordosis–scoliosis–kyphosis (LSK) or opercular, dental or jaw malformations in comparison with control (CT) specimens. Results showed a possible link between the presence of LD and LSK and the significant downregulation of genes involved in osteoblasts' maturation and matrix mineralization (collagen type 1‐alpha, osteopontin, osteocalcin, matrix Gla protein and tissue non‐specific alkaline phosphatase), as well as in bone resorption (cathepsin K and matrix metalloproteinase 9) compared to CT animals. Contrarily, the key osteogenic transcription factor runx2 was upregulated in the malformed vertebra suggesting impaired determination of mesenchymal stem cells towards the osteoblastic lineage. Despite the gene expression patterns of the other malformed structures were not affected in comparison with CT fish, the results of the present study may contribute in the long term to identify potential candidate gene profiles associated with column deformities that may help reducing the incidence of appearance of skeletal anomalies in this important aquaculture species.

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“…Consequently, they provide a powerful tool for the evaluation of the breeding value of candidates to selection as well as for the management of genetic variability in breeding programs. The approach of resolving pedigrees using molecular markers in order to obtain estimates of genetic parameters in sea bream has been previously applied by several authors (Navarro et al 2009;Antonello et al 2009;Chavanne et al 2014;García-Celdrán et al 2015;Lee-Montero et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Estimation of genetic parameters for growth traits in a hatchery population of gilthead sea bream (Sparus aurata L.)

Fernandes

Herlin²,

Belluga³

et al. 2016

Aquacult Int

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The gilthead sea bream (Sparus aurata L.) is one of the most important marine fish species produced in southern European countries. Over the last two decades, microsatellites have become a powerful tool for DNA studies of fish populations, making it possible to establish existing genealogical relationships between individuals and to perform reliable estimates of genetic parameters. In the present study, a total of 7959 fish (494 breeders and 7465 fry) were genotyped using two rounds of multiplex reactions with four microsatellite markers each. Offspring were assigned based on the Mendelian exclusion principles, using FAP program. Genealogical information was successfully obtained for more than 83 % of the progeny. Heritability estimates were close to 0.40 in all cases and for all considered traits. The lowest value was for the length at first age (350 ± 6 dph) and the highest for the length at the second age (500 ± 7 dph). The heritabilities for the first and the second weight were similar although somewhat higher for the second age, but not significant. The highest genetic correlations were found between weight and length at the same age and the lowest between weight and length at different ages. Based on the results of this study, it seems reasonable to expect that the implementation of a breeding program for improved growth in this population of gilthead sea bream will offer comparable & Tiago Fernandes

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Estimates of heritabilities and genetic correlations of growth and external skeletal deformities at different ages in a reared gilthead sea bream (Sparus aurata L.) population sourced from three broodstocks along the Spanish coasts

Cited by 30 publications

References 44 publications

Heritability Estimates and Genetic Correlation for Growth Traits and LCDV Susceptibility in Gilthead Sea Bream (Sparus aurata)

Heritability Estimates and Genetic Correlation for Growth Traits and LCDV Susceptibility in Gilthead Sea Bream (Sparus aurata)

Gene expression analyses in malformed skeletal structures of gilthead sea bream (Sparus aurata)

Estimation of genetic parameters for growth traits in a hatchery population of gilthead sea bream (Sparus aurata L.)

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