Estimates of influenza and respiratory syncytial virus incidences with fraction modeling approach in Baguio City, the Philippines, 2012‐2014

Kamigaki, Taro; Aldey, Portia P.; Mercado, Edelwisa S.; Tan, Alvin G.; Javier, Jenaline B.; Lupisan, Socorro; Oshitani, Hitoshi; Tallo, Veronica

doi:10.1111/irv.12453

Cited by 10 publications

(7 citation statements)

References 23 publications

(41 reference statements)

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“…The overall burden of RSV among health-seeking populations has mostly been evidenced in young children, adults above 65 years of age, pregnant women or immunocompromised patients in whom equivalent disease burden to influenza has been reported [ 19 – 21 ]. The estimation of severe RSV infections in Switzerland is limited by the lack of an active RSV surveillance system.…”

Section: Discussionmentioning

confidence: 99%

Burden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study

et al. 2018

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BackgroundRespiratory syncytial virus (RSV) is associated with significant mortality rates amongst hematopoietic stem cell transplant (HSCT) recipients, with less known about other immunocompromised patients.MethodsTen-year retrospective cohort study of immunocompromised patients presenting with RSV disease documented at University Hospitals of Lausanne and Geneva. Severe RSV-related outcomes referred to RSV documented respiratory conditions requiring hospital admission, presenting as lower respiratory tract infection (LRTI) or pneumonia. We used multivariable logistic regression to assess clinical and laboratory correlates of severe RSV disease.ResultsFrom 239 RSV-positive immunocompromised in and out-patients 175 were adults and 64 children of whom 111 (47.8%) presented with LRTI, which resulted in a 38% (89/239) admission rate to hospital. While immunocompromised children were more likely to be admitted to hospital compared to adults (75% vs 62.9%, p = 0.090), inpatients admitted to the intensive care unit (17/19) or those who died (11/11) were mainly adults. From multivariable analyses, adults with solid tumors (OR 5.2; 95% CI: 1.4–20.9 P = 0.015) or those requiring chronic immunosuppressive treatments mainly for rheumatologic conditions (OR 4.1; 95% CI: 1.1–16.0; P = 0.034) were significantly more likely to be admitted to hospital compared to hematopoietic stem cell (HSCT) recipients. Bacterial co-infection was significantly and consistently associated with viral LRTI and pneumonia.ConclusionsFrom our findings, RSV-related disease results in a significant burden among adults requiring chronic immunosuppressive treatments for rheumatological conditions and those with solid tumors. As such, systematic screening for respiratory viruses, should be extended to other immunocompromised populations than HSCT recipients.Electronic supplementary materialThe online version of this article (10.1186/s12879-018-3002-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Burden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study

et al. 2018

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“…Excellent surveillance across the Philippines consistently shows RSV ranking as one of the top two most commonly detected respiratory viruses each year, and as the leading cause of hospitalization among infants and young children [ 25 , 26 , 27 , 37 , 38 , 39 , 40 ]. Furuse et al found that nearly 24% of all RSV-infected children visit a medical facility during their infection, with 2% requiring hospitalization [ 38 ].…”

Section: Rsv Disease Activity Across Tropical Asiamentioning

confidence: 99%

“…In Baguio City (population ~350,000; elevation 4800 ft), the average RSV incidence rates are reported at 1.4 per 1000 individuals, with the highest age-group-specific incidence rates of 21.7–38 per 1000 individuals occurring in infants 6–23 months of age [ 40 ]. Among children less than 6 mos of age, mean hospitalization rates for RSV were between 2 and 8-fold higher than for influenza.…”

Section: Rsv Disease Activity Across Tropical Asiamentioning

confidence: 99%

“…Year to year, viral activity across the Philippines is predictably most pronounced between September and December, with some regional variability. Peak infections tend to occur during the rainy months of October and November [ 25 , 37 , 40 , 42 , 43 ]. The interplay between meteorology, host and socioeconomic factors is notable as the rainy season has been shown to be associated with more advanced malnutrition, a known risk factor for severe RSV disease [ 43 ].…”

Section: Rsv Disease Activity Across Tropical Asiamentioning

confidence: 99%

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Epidemiology and Seasonality of Childhood Respiratory Syncytial Virus Infections in the Tropics

Suryadevara

Domachowske

2021

Viruses

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Infections caused by respiratory syncytial virus (RSV) are a major cause of morbidity and mortality in young children worldwide. Understanding seasonal patterns of region-specific RSV activity is important to guide resource allocation for existing and future treatment and prevention strategies. The decades of excellent RSV surveillance data that are available from the developed countries of the world are incredibly instructive in advancing public health initiatives in those regions. With few exceptions, these developed nations are positioned geographically across temperate regions of the world. RSV surveillance across tropical regions of the world has improved in recent years, but remains spotty, and where available, still lacks the necessary longitudinal data to determine the amount of seasonal variation expected over time. However, existing and emerging data collected across tropical regions of the world do indicate that patterns of infection are often quite different from those so well described in temperate areas. Here, we provide a brief summary regarding what is known about general patterns of RSV disease activity across tropical Asia, Africa and South America, then offer additional country-specific details using examples where multiple reports and/or more robust surveillance data have become available.

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“…Although the highest number of cases overall was associated with influenza A, most cases of RSV, adenoviruses, B. pertussis , and enteroviruses occurred in children less than ten years old. These organisms were previously reported to be most common among children [ 15 – 18 ]. Further, RSV had the highest incidence among children less than 5 years old, but another increase in RSV hospitalization rates was observed among elderlies (≥60 years old).…”

Section: Discussionmentioning

confidence: 99%

Acute Respiratory Tract Infections among Hospitalized Palestinian Patients (2011–2016): A Retrospective Study

Seir

Njoum

Najajrah

et al. 2021

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Respiratory tract infections (RTIs) are a major public health concern. This study aims to investigate the profiles and epidemiological characteristics of acute RTIs and respiratory pathogens in Palestinian hospitalized patients. Clinical samples from hospitalized patients with symptoms of acute RTIs admitted between January 2011 and December 2016 were referred to the Palestinian Central Public Health Laboratory (PHCL) to identify the causative pathogen. Patients’ demographic information and the results of the molecular identification were retrieved from the electronic database at the PHCL. A total of 15413 patients with acute RTIs were hospitalized during the study period. The causal agent was identified only in 28.7% of the patients. Overall, influenza viruses were the most common cause of RTIs among hospitalized Palestinian patients in the West Bank. Children and elderlies were the most affected with RTIs. The elderly population (≥60 years old) had the highest rates. After influenza A virus, respiratory syncytial virus (RSV), and Bordetella pertussis (B. pertussis) were the most common causes of acute RTIs among hospitalized Palestinian patients. Children showed the highest hospitalization rates for RSV, B. pertussis, adenovirus, enterovirus, and Streptococcus pneumoniae. On the other hand, elderlies had the highest rates of influenza. Outbreaks of RTIs occurred mainly during winter (between December and March). The resurgence of B. pertussis in spite of vaccination is alarming and requires further investigation.

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Estimates of influenza and respiratory syncytial virus incidences with fraction modeling approach in Baguio City, the Philippines, 2012‐2014

Cited by 10 publications

References 23 publications

Burden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study

Burden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study

Epidemiology and Seasonality of Childhood Respiratory Syncytial Virus Infections in the Tropics

Acute Respiratory Tract Infections among Hospitalized Palestinian Patients (2011–2016): A Retrospective Study

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