Estimates of lung and pancreatic cancer survival in Sweden with and without inclusion of death certificate initiated (DCI) cases

Lambe, Mats; Wigertz, Annette; Sandin, Fredrik; Holmberg, Erik; Amsler-Nordin, Susanne; Andersson, Therése; Pettersson, David

doi:10.1080/0284186x.2020.1826572

Cited by 5 publications

(6 citation statements)

References 16 publications

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“…Moreover, there might be misclassification of the pancreatic cancer outcome since the associations estimated using NPR diagnoses might have included not confirmed cancer cases. On the other hand, in the models using SCR there may be misclassified patients with pancreatic cancer in the control groups due to potential under‐recording of pancreatic cancer in SCR, being approximately 30% 41,42 . Finally, in NPR, specific coding may have been induced due to economic incentives, but it was impossible to detect this aspect in the present study 44,45 …”

Section: Discussionmentioning

confidence: 67%

“…On the other hand, in the models using SCR there may be misclassified patients with pancreatic cancer in the control groups due to potential under-recording of pancreatic cancer in SCR, being approximately 30%. 41,42 Finally, in NPR, specific coding may have been induced due to economic incentives, but it was impossible to detect this aspect in the present study. 44,45 Remaining uncertainties about the mechanisms behind the in/consistency need to be addressed.…”

Section: Strengths and Limitationsmentioning

confidence: 60%

“…However, this should be interpreted with caution. Previous studies found that about 30% of pancreatic cancers were underreported in SCR compared to NPR 41,42 . Cancers that require a highly invasive diagnostic process, such as pancreatic cancer, may not be histopathologically confirmed in elderly patients.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies found that about 30% of pancreatic cancers were underreported in SCR compared to NPR. 41,42 Cancers that require a highly invasive diagnostic process, such as pancreatic cancer, may not be histopathologically confirmed in elderly patients. Therefore, even when symptoms of pancreatic cancer are present, the cancer may be registered in NPR as a suspected cancer without pathologically confirming but not recorded in SCR.…”

Section: Discussionmentioning

confidence: 99%

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Consistency between the National Patient Register and the Swedish Cancer Register

Sakakibara,

Pazzagli,

Linder

2024

Pharmacoepidemiology and Drug

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PurposeThe Swedish National Patient Register (NPR) is widely used as a data source in epidemiological studies, but the consistency of all cancer diagnoses compared to the Swedish Cancer Register (SCR) remains unclear. Using NPR supplementary for detecting safety signals is beneficial due to shorter data extraction delays compared to using SCR alone. This study aims to evaluate the consistency of NPR for cancer diagnoses compared to SCR and its potential use in pharmacoepidemiology.MethodsPatients with a cancer diagnosis recorded in SCR during 2018–2020 were included. To measure the consistency of NPR diagnoses with SCR as the gold standard, positive predictive value (PPV), and sensitivity were calculated. As an empirical example showing differences in identification of cancer diagnoses in NPR and SCR, two nested case–control studies for the association between antidiabetic medications and pancreatic cancer were repeated using the two registers. Conditional logistic regression was performed and the 95% confidence intervals (CIs) for the odds ratios (ORs) were checked for overlaps.ResultsFor breast, male genital organs, and oral cancers consistency was high (PPV: 87.5%–97.4%, sensitivity: 82.2%–91.0%), while for female genital organs, thyroid, and ill‐defined, secondary, and unspecified sites cancers it was low (PPV: 8.8%–90.0%, sensitivity: 19.9%–32.3%). All the CIs for the ORs from the nested case–control studies overlapped when pancreatic cancer was identified in NPR or SCR.ConclusionConsistency of cancer diagnoses in NPR when compared to SCR depends on cancer type with higher consistency for some cancers and lower for others. Differences in diagnostic processes for different cancer types and coding of cancer in the two registers may explain part of the inconsistent results.

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Section: Discussionmentioning

confidence: 67%

Section: Strengths and Limitationsmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Consistency between the National Patient Register and the Swedish Cancer Register

Sakakibara,

Pazzagli,

Linder

2024

Pharmacoepidemiology and Drug

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“…The study results are limited by the fact that poor-prognosis cancers requiring invasive diagnostic procedures for pathological confirmation are underreported in the Swedish Cancer Register ( 17 , 18 ). Indeed, when comparing the number of cancer deaths with a previous cancer record with publicly available death statistics published by the Swedish National Board of Health and Welfare, we missed 394 (11%) lung, 451 (22%) pancreatic, and 400 (29%) hepatobiliary cancer deaths in 2019 ( Supplementary Table 2 , available online) ( 18 ). Cause of death certificates can, however, both over- and underestimate cancer-specific mortality ( 17 ), and prostate cancer is probably overreported as a cause of death ( 19 ).…”

mentioning

confidence: 97%

Reranking cancer mortality using years of life lost

Radkiewicz

Andersson

Lagergren

2023

JNCI Cancer Spectrum

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Incidence and mortality are default measures to describe cancer trends. Mortality compounds incidence and survival but not age at death. We calculated years of life lost (YLL) due to 1 of the 10 solid tumors causing most deaths (lung, colorectal, prostate, pancreatic, breast, hepatobiliary, urinary, central nervous system, gastric, melanoma) using Swedish National Cancer and Cause of Death Registers. Comparing YLL with mortality in 2019, lung (43 152 YLL) and colorectal (32 340 YLL) cancer remained at the top, pancreatic cancer was upranked fourth to third (22 592 YLL) and breast cancer fifth to fourth (21 810 YLL), while prostate cancer was downranked third to fifth (17 380 YLL). Assessing YLL over 2010-2019, women lost consistently more life years because of lung and pancreatic cancer. A downward colorectal cancer mortality trend was reflected as a YLL decline only in women. YLL is simple to calculate, is intuitive to interpret, and expands the understanding of the cancer burden on society.

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The validity of cancer information on death certificates in Norway and the impact of death certificate initiated cases on cancer incidence and survival

Møller

Jerm

Larønningen

et al. 2021

Cancer Epidemiology

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Estimates of lung and pancreatic cancer survival in Sweden with and without inclusion of death certificate initiated (DCI) cases

Abstract: Pettersson (2020): Estimates of lung and pancreatic cancer survival in Sweden with and without inclusion of death certificate initiated (DCI) cases, Acta Oncologica,

Cited by 5 publications

References 16 publications

Consistency between the National Patient Register and the Swedish Cancer Register

Consistency between the National Patient Register and the Swedish Cancer Register

Reranking cancer mortality using years of life lost

The validity of cancer information on death certificates in Norway and the impact of death certificate initiated cases on cancer incidence and survival

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