Estimating a woman's risk of having a pregnancy associated with Down's syndrome using her age and serum alphafetoprotein level

Hs, Cuckle; Wald, NJ; Thompson, SG

doi:10.1016/0020-7292(88)90310-4

Cited by 29 publications

(34 citation statements)

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“…The fi nding of an association between low serum AFP and elevated serum hCG with foetal chromosomal abnormalities, including DS (15) , has led to the double test (AFP and hCG) (38) . The third marker for DS was unconjugated oestriol, which was found to be lower in the affected pregnancies (19) .…”

Section: Second Trimester Screening Testsmentioning

confidence: 99%

Recommendations on prenatal screening and the connections to other diseases such as thyroid dysfunction

Springer

Potluková²,

Límanová³

et al. 2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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The aim of general maternal-foetal care is to ensure an uncomplicated birth of a healthy baby to a healthy mother. There is a large range of screening tests used during pregnancy: for gestational diabetes, infection, rhesus-D status, thyroid dysfunction, as well as other tests. An important part of prenatal care is the screening of major aneuploidies, primarily for Down ' s syndrome. This screening is possible in either the fi rst or second trimester, or in both. Management of this type of screening is very similar around the world. Hypothyroidism can affect the psychomotor development of the child. Thyroidstimulating hormone (TSH), autoantibodies against thyroperoxidase (TPOAb), and free thyroxin (FT4) were determined within our group of 7530 pregnant women. Elevated concentrations of TSH were found in 5.1 % , suppression was found in 2.9 % and 11.5 % were TPOAb positive. Either a familial or personal history of thyroid or autoimmune diseases was present in 58.3 % of those women who tested positive on any thyroid test. At minimum, 40 % of women TPOAb positive during pregnancy have some kind of thyroid disorders after delivery. These results support the effi cacy of general thyroid function screening in early pregnancy, as well as the follow-up after delivery of those women who are positive.

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Section: Second Trimester Screening Testsmentioning

confidence: 99%

Recommendations on prenatal screening and the connections to other diseases such as thyroid dysfunction

Springer

Potluková²,

Límanová³

et al. 2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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show abstract

“…Moreover, in 1996, inhibin-A was found to contribute to the current triple test (Wald et al, 1996) and with the addition of inhibin-A the 'quadruple test' was conceived. (Cuckle et al, 1987).…”

Section: Prenatal Screening For Down Syndromementioning

confidence: 99%

Innovations in Down Syndrome Screening

Koster¹,

Vries²,

Visser³

et al. 2011

Prenatal Diagnosis and Screening for Down Syndrome

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“…To increase the precision of the estimates we combine our results with four previously published studies (Hook et al, 1995(Hook et al, , 1989Cuckle et al, 1987;Macintosh et al, 1995Macintosh et al, , 1996Halliday et al, 1995).…”

Section: Introductionmentioning

confidence: 99%