Estimating allele frequencies of some hereditary diseases in Holstein cattlereared in Burdur Province, Turkey

Abstract

The economics of dairy cattle breeding around the world has been significantly affected by the autosomal recessive hereditary diseases of bovine leukocyte adhesion deficiency (BLAD), factor XI deficiency (FXID), bovine citrullinemia (BC), and deficiency of uridine monophosphate synthase (DUMPS). The aim of this study was to determine BLAD, FXID, BC, and DUMPS alleles in Holstein cattle raised in Burdur Province in Turkey. This study involved taking blood samples randomly from 500 head of Holstein cattle at various dairy farms in different towns in Burdur Province. Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis was employed to identify cows with these diseases. The results showed that the percentages of carrier animals for BLAD and FXID were 2% and 1.8%, respectively, while no DUMPS or BC was found in the study population. This is the first study on BLAD, FXID, BC, and DUMPS in Holstein cattle raised in Burdur Province in Turkey.

Carrier frequency of autosomal recessive disorders (BC, BLAD, FXID and CVM) in Holstein cows in Jalisco, Mexico

“…In Turkey, FXID carrier frequency studies have been conducted in diverse regions. In the Bursa region (Oner et al 2010), carrier frequency of 1.17% was found, in the Burdur region it was 1.8% (Korkmaz Ağaoğlu et al 2015), and in the Thrace region no FXID carriers were found (Avanus & Ahmet 2016), as in the present study. However, for FXID, besides the number of animals sampled, the choice of random or deliberate selection criteria may also be related to the variability in FXID prevalence rates between different countries.…”

“…Whereas the reported carrier frequency in the USA was 0.3% (Robinson et al 1993), it was 13% in Australia, the highest reported prevalence (Healy 1996). Generally, carrier frequencies are very low, as in the case of China with 0.16% (Li et al 2011), or null as we found here, which was also reported in Germany (Grupe et al 1996), Czech Republic (Citek et al 2006), India (Patel et al 2006), and Turkey (Korkmaz Ağaoğlu et al 2015). While the FXID, BC, BLAD, and CVM related alleles have been reported in various countries, in Mexico there are no previous studies of these mutations, except a single study for BLAD (Riojas Valdés et al 2009).…”

“…cattle (Korkmaz Ağaoğlu et al 2015). BC, which is caused by a single-base substitution (C to T) at codon 86, converting it to a nonsense codon of the gene coding of argininosuccinate synthetase ASS gene, on bovine chromosome 11 (Dennis et al 1989), is characterized by hyperammonemia due to urea cycle interruption, which leads to neurological problems resulting ultimately in coma and death in the first week of life (Harper et al 1986, Dennis et al 1989.…”

Inherited Diseases of Holstein Cattle: Story So Far in Turkey

“…No DUMPS and BC carriers were identified in Turkey so far Akyuz & Kul, 2009;Meydan et al, 2010;Oner et al, 2010;Kulaklı & Akyuz 2011;Karslı et al, 2011;Sahin et al 2013;Korkmaz Agaoglu et al, 2015;Kaya et al, 2016).…”

Inherited Diseases of Holstein Cattle: Story So Far in Turkey

“…No DUMPS and BC carriers were identified in Turkey so far Akyuz & Kul, 2009;Meydan et al, 2010;Oner et al, 2010;Kulaklı & Akyuz 2011;Karslı et al, 2011;Sahin et al 2013;Korkmaz Agaoglu et al, 2015;Kaya et al, 2016).…”