Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case‐control studies from 27 countries

Conway, David I.; Brenner, Darren R.; McMahon, Alex D.; Macpherson, L.M.D.; Agudo, Antonio; Ahrens, Wolfgang; Bosetti, Cristina; Brenner, Hermann; Castellsagué, Xavier; Chen, Chu; Curado, María Paula; Curioni, Otávio Alberto; Maso, Luigino Dal; Daudt, Alexander W.; Filho, José Francisco de Góis; D’Souza, Gypsyamber; Edefonti, Valeria; Fabiánovà, Eleonóra; Fernández, Leticia; Franceschi, Silvia; Gillison, Maura L.; Hayes, Richard B.; Healy, Claire M.; Herrero, Rolando; Holcátová, Ivana; Jayaprakash, Vijayvel; Kelsey, Karl T.; Kjærheim, Kristina; Koifman, Sérgio; Vecchia, Carlo La; Λάγιου, Παγώνα; Lazarus, Philip; Levi, Fabio; Lissowska, Jolanta; Luce, Danièle; Macfarlane, Tatiana V.; Mateș, Dana; Matos, Elena; McClean, Michael D.; Menezes, Ana; Menvielle, Gwenn; Merletti, Franco; Morgenstern, Hal; Moysich, Kirsten B.; Müller, Heiko; Muscat, Joshua E.; Olshan, Andrew F.; Purdue, Mark P.; Ramroth, Heribert; Richiardi, Lorenzo; Rudnai, Péter; Schantz, Stimson P.; Schwartz, Stephen M.; Shangina, Oxana; Simonato, Lorenzo; Smith, Elaine; Stücker, Isabelle; Sturgis, Erich M.; Szeszenia-Da̧browska, Neonila; Talamini, Renato; Thomson, Peter; Vaughan, Thomas L.; Wei, Qingyi; Winn, Deborah M.; Wünsch-Filho, Victor; Gao, Yu; Zhang, Zuo‐Feng; Zheng, Tongzhang; Znaor, Ariana; Boffetta, Paolo; Chuang, Shu Chun; Ghodrat, Marianoosh; Lee, Yuan Chin Amy; Hashibe, Mia; Brennan, Paul

doi:10.1002/ijc.29063

Cited by 129 publications

(110 citation statements)

References 38 publications

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“…C44), oesophagus (C15), stomach (C16), colorectum (C18-21), pancreas (C25), trachea, bronchus and lung (C33-34), melanoma of skin (C43), female breast (C50), cervix uteri (C53), prostate (C61), kidney (64) and leukaemia (C91-95). In addition, cancers of the head and neck (C00-14) and testis (C62) were included because of their known or suspected link with socioeconomic status (11,12).…”

Section: Data On Cancer Incidence Between 2003 and 2007 Were Extractementioning

confidence: 99%

Inequalities in cancer incidence and mortality across medium to highly developed countries in the twenty-first century

Arnold

Rentería

Conway

et al. 2016

Cancer Causes Control

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(250 words)Purpose: Inequalities in the burden of cancer have been well-documented and a variety of measures exist to analyse disease disparities. While previous studies have focused on inequalities within countries, the aim of the present study was to quantify existing inequalities in cancer incidence and mortality between countries.Methods: Data on total and site-specific cancer incidence and mortality in [2003][2004][2005][2006][2007] were obtained for 43 countries with medium to high levels of human development via Cancer Incidence in Five Continents Vol. X and the WHO Mortality Database. We calculated the concentration index as a summary measure of socioeconomic-related inequality between countries.Results: Inequalities in cancer burden differed markedly by site; the concentration index for all sites combined was 0.03 for incidence and 0.02 for mortality, pointing towards a slightly higher burden in countries with higher levels of the Human Development Index (HDI). For both incidence and mortality, this pattern was most pronounced for melanoma. In contrast, the burden of cervical cancer was disproportionally high in countries with lower HDI levels. Prostate, lung and breast cancer contributed most to inequalities in overall cancer incidence in countries with higher HDI levels, while for mortality these were mostly driven by lung cancer in higher HDI countries and stomach cancer in countries with lower HDI levels. Conclusion:Global inequalities in the burden of cancer remain evident at the beginning of the 21 st century:with a disproportionate burden of lifestyle-related cancers in countries classified as high HDI, while infectionrelated cancers continue to predominate in transitioning countries with lower levels of HDI.

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Section: Data On Cancer Incidence Between 2003 and 2007 Were Extractementioning

confidence: 99%

Inequalities in cancer incidence and mortality across medium to highly developed countries in the twenty-first century

Arnold

Rentería

Conway

et al. 2016

Cancer Causes Control

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confidence: 99%

“…Socioeconomic deprivation can therefore be considered a proxy variable for non-spatial access to treatment. Further, while socioeconomic deprivation is a well-established predictor of cancer incidence [19][20][21][22][23][24] , rates of treatment 25 , and survival 24,[26][27][28][29] , there is some evidence that these socioeconomic disparities also reflect poor spatial access to screening, diagnosis, and treatment 6,7,24,[30][31][32][33] .…”

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confidence: 99%

Socioeconomic disparities in head and neck cancer patients’ access to cancer treatment centers

Walker

Schuurman

Auluck³

et al. 2017

Rural Remote Health

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Introduction: Both socioeconomic status and travel time to cancer treatment have been associated with treatment choice and patient outcomes. An improved understanding of the relationship between these two dimensions of access may enable cancer control experts to better target patients with poor access, particularly in isolated suburban and rural communities. Methods: Using geographical information systems, head and neck cancer patients across British Columbia, Canada from 1981 to 2009, were mapped and their travel times to the nearest treatment center at their time of diagnosis were modelled. Patients' travel times were analysed by urban, suburban, and rural neighborhood types and an index of multiple socioeconomic deprivation was used to assess the role of socioeconomic status in patients' spatial access. Results: Significant associations between socioeconomic deprivation and spatial access to treatment were identified, with the most deprived quintiles of patients experiencing nearly twice the travel time as the least deprived quintile. The sharpest disparities were observed among the most deprived patient populations in suburban and rural areas. However, the establishment of new treatment centers has decreased overall travel times by 28% in recent decades. Conclusions: Residence in a neighborhood with high socioeconomic deprivation is strongly associated with head and neck cancer patients' spatial access to cancer treatment centers. Patients residing in the most socioeconomically deprived neighborhoods consistently have longer travel times in urban, suburban, and rural communities in the study area.Key words: cancer treatment, socioeconomic status, deprivation, head and neck cancers, spatial access, geographic information systems, Canada.© BB Walker, N Schuurman, A Auluck, SA Lear, M Rosin 2017. A Licence to publish this material has been given to James Cook University, http://www.jcu.edu.au 2 IntroductionWith an estimated 525 000 new cases in 2012, head and neck cancers are the eighth most common non-melanoma cancers globally 1. This number is expected to grow significantly in the coming decades, resulting in increased demand for treatment 2 .To maximize efficiency, comprehensive cancer treatment facilities are most commonly located in areas where they service the largest proportion of the patient population, generally in large urban centers. This results in a geographical inequity, such that individuals living farther from a cancer treatment center experience a greater travel burden in order to attend their treatment, particularly those living in rural and remote areas , and survival 14. The time required for patients to travel from the home to a cancer treatment center is therefore an important factor throughout the continuum of care, and may inform more efficient and equitable cancer control programs and policy.The travel time required for an individual to reach a treatment center provides a quantitative measure of access 15 . However, an individual's access to a health service may also be measured as the ...

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“…Uma meta análise recentemente publicada por um grupo de estudos multicêntrico estabelece que o baixo estrato sócio -económico pode ser considerado como um fator de risco independente para determinados indivíduos poderem vir a contrair tumores nestas regiões. 10 Em Portugal não existem estudos específicos sobre este tema e, neste contexto, foi desenvolvido este estudo que tem como objetivo analisar os aspetos epidemiológicos e demográficos dos doentes portadores de tumores malignos da cabeça e do pescoço referenciados ao Serviço de Otorrinolaringologia (ORL) do Instituto Português de Oncologia (IPO) do Porto. Foi nossa intenção ainda avaliar a influência dessas característi-cas no estadio dos tumores e na sobrevivência global dos doentes, e ainda, alertar as instituições de saúde para um perfil demográfico e social destas populações, sobre as quais poderão ser implementados programas de prevenção e de rastreio.…”

Section: 4unclassified

Características Epidemiológicas e Demográficas dos Doentes Portadores de Tumores da Cabeça e Pescoço no Norte de Portugal: Impacto na Sobrevivência

et al. 2016

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The analyzed variables were the anatomical location of the tumor, staging, gender and age of patients, the district of origin, the alcohol and tobacco consumption, educational level, occupation, marital status and family structure. Results:The 566 patients studied (498 men and 68 women) presented a mean age of 58.1 ± 12.2 years. The majority (80.5%) were referenced in advanced stage of disease (III and IV). Seventy eight per cent of patients had moderate or excessive alcohol consumption and 69% were smokers. The vast majority of patients (82.3%) had only basic education. Patients with tumors of the hypopharynx and excessive drinking habits were referenced in more advanced stages and had a poorer survival (p < 0.001). Married patients were referred at earlier stages (p = 0.020) and patients without family support had poorer survival (p = 0.030). Discussion: Epidemiological data are in agreement with the international literature. The high rate of patients referred with advanced stage of disease can be attributed to the patient´s delay in seeking medical care or by factors inherent to the referral system. Surveillance and family support play a key role in early referral and survival of these patients. Conclusion:This study features a population profile that can benefit from a higher degree of surveillance, awareness campaigns and/ or screenings. Some of the variables can significantly influence the tumor stage and survival.

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Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case‐control studies from 27 countries

Cited by 129 publications

References 38 publications

Inequalities in cancer incidence and mortality across medium to highly developed countries in the twenty-first century

Inequalities in cancer incidence and mortality across medium to highly developed countries in the twenty-first century

Socioeconomic disparities in head and neck cancer patients’ access to cancer treatment centers

Características Epidemiológicas e Demográficas dos Doentes Portadores de Tumores da Cabeça e Pescoço no Norte de Portugal: Impacto na Sobrevivência

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