Estimating dual-energy X-ray absorptiometry-derived total body skeletal muscle mass using single-slice abdominal magnetic resonance imaging in obese subjects with and without diabetes: a pilot study

Baker, Scott; Strauss, Boyd Josef Gimnicher; Prendergast, Luke A.; Panagiotopoulos, Sianna; Thomas, Georgina; Vu, Thuy; Proietto, J.; Jerums, George

doi:10.1038/ejcn.2012.3

Cited by 17 publications

(15 citation statements)

References 26 publications

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“…The total area of skeletal muscle of a single cross-sectional image at the L4-5 interface, normalized for height, was found to be highly correlated with both total body skeletal muscle (r = 0.9) and adipose tissue (r = 0.94) in a study in which whole-body magnetic resonance images were used as the reference standard (15). Additional investigators validated single-section cross-sectional muscle measurement at various levels as an accurate estimate of muscle mass (14). At the level of the L4-5 interface, the Eclipse CT ranger tool (https:// github.com/rexcardan/AverageHU_ES-API) was used to automatically generate a structure that contained all voxels with attenuation between 229 HU and 150 HU on the section (19).…”

Section: End Point Definitions and Statistical Methodsmentioning

confidence: 93%

“…While the purpose of treatment-planning CT is to delineate target volumes and assess tissue attenuation to perform accurate dose calculations, additional anatomic information is obtained that may be of clinical value. A number of reports have confirmed that bone mineral density (BMD) (11)(12)(13) and total body muscle mass (14,15) can be estimated accurately from abdominal and pelvic images obtained for other reasons. Osteopenia (16) and sarcopenia (17,18) have both been associated with an increased risk of noncancer death in a number of different populations.…”

Section: Ct Metrics Of Body Compositionmentioning

confidence: 99%

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CT Measures of Bone Mineral Density and Muscle Mass Can Be Used to Predict Noncancer Death in Men with Prostate Cancer

McDonald¹,

Swain

Mayhew³

et al. 2017

Radiology

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Purpose To determine if computed tomographic (CT) metrics of bone mineral density and muscle mass can improve the prediction of noncancer death in men with localized prostate cancer. Materials and Methods Institutional review board approval was obtained, with waiver of informed consent. All patients who underwent radiation therapy for localized prostate cancer between 2001 and 2012 with height, weight, and past medical history documented and who underwent CT that included the L4-5 vertebral interspace were included. On a single axial CT section obtained at the mid-L5 level, the mean CT attenuation of the trabecular bone of the L5 vertebral body (L5) was measured. The height-normalized psoas cross-sectional area (Psoas) was measured on a single CT section obtained at the L4-5 vertebral interface. Multivariable Cox proportional hazards models were used to assess effects on noncancer death. By using parameter estimates from an adjusted model, a prognostic index for prediction of noncancer death was generated and compared with age-adjusted Charlson Comorbidity Index (CCI) by using the Harrell c statistic. Results Six hundred fifty-three men met the inclusion criteria. Prostate cancer risk grouping, androgen deprivation, race, age-adjusted CCI, L5, and Psoas were included in a multivariable model. Age-adjusted CCI (hazard ratio [HR] = 1.36, P < .001), L5 (HR = 2.88 for L5 < 105 HU, HR = 1.42 for 105 HU ≤ L5 ≤ 150 HU, P < .001), Psoas (HR = 1.95 for Psoas < 7.5 cm/m, P = .003), and race (HR = 1.68 for African American race, HR = 1.77 for other nonwhite race, P = .019) were independent predictors of noncancer death. The prognostic index yielded a c value of 0.747 for the prediction of noncancer death versus 0.718 for age-adjusted CCI alone. Conclusion L5 and Psoas, which are surrogates for bone mineral density and muscle mass, respectively, were independent predictors of noncancer death. The prognostic index that incorporated these measures with the CCI was associated with improved accuracy for prediction of noncancer death. RSNA, 2016 Online supplemental material is available for this article.

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Section: End Point Definitions and Statistical Methodsmentioning

confidence: 93%

Section: Ct Metrics Of Body Compositionmentioning

confidence: 99%

CT Measures of Bone Mineral Density and Muscle Mass Can Be Used to Predict Noncancer Death in Men with Prostate Cancer

McDonald¹,

Swain

Mayhew³

et al. 2017

Radiology

View full text Add to dashboard Cite

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“…), hence, reducing inter‐observer variability. Furthermore, manual tracing of image sets comprised of several axial slices was performed, thus allowing exact tracking of muscles based on the traced boundaries (Baker et al ., ; Taguchi et al ., ). Lastly, the manual tracing method used in this study compensates for any potential image artifacts.…”

Section: Discussionmentioning

confidence: 99%

“…The image analysis of trunk muscles was performed using axial plane images at the third lumbar vertebrae (L 3 ) (Zhou et al ., ; Shen et al ., ; Mourtzakis et al ., ; MacDonald et al ., ; Baker et al ., ). The inter‐reader and intrareader reproducibility of manual analysis of body composition using MRI scans have shown reliability of this approach (Maurovich‐Horvat et al ., ; MacDonald et al ., ).…”

Section: Methodsmentioning

confidence: 97%

Muscles of the trunk and pelvis are responsive to testosterone administration: data from testosterone dose–response study in young healthy men

et al. 2017

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Testosterone dose-dependently increases appendicular muscle mass. However, the effects of testosterone administration on the core muscles of the trunk and the pelvis have not been evaluated. The present study evaluated the effects of testosterone administration on truncal and pelvic muscles in a dose-response trial. Participants were young healthy men aged 18-50 years participating in the 5α-Reductase (5aR) Trial. All participants received monthly injections of 7.5 mg leuprolide acetate to suppress endogenous testosterone production and weekly injections of 50, 125, 300, or 600 mg of testosterone enanthate and were randomized to receive either 2.5 mg dutasteride (5aR inhibitor) or placebo daily for 20 weeks. Muscles of the trunk and the pelvis were measured at baseline and the end of treatment using 1.5-Tesla magnetic resonance imaging. The dose effect of testosterone on changes in the psoas major muscle area was the primary outcome; secondary outcomes included changes in paraspinal, abdominal, pelvic floor, ischiocavernosus, and obturator internus muscles. The association between changes in testosterone levels and muscle area was also assessed. Testosterone dose-dependently increased areas of all truncal and pelvic muscles. The estimated change (95% confidence interval) of muscle area increase per 100 mg of testosterone enanthate dosage increase was 0.622 cm (0.394, 0.850) for psoas; 1.789 cm (1.317, 2.261) for paraspinal muscles, 2.530 cm (1.627, 3.434) for total abdominal muscles, 0.455 cm (0.233, 0.678) for obturator internus, and 0.082 cm (0.003, 0.045) for ischiocavernosus; the increase in these volumes was significantly associated with the changes in on-treatment total and free serum testosterone concentrations. In conclusion, core muscles of the trunk and pelvis are responsive to testosterone administration. Future trials should evaluate the potential role of testosterone administration in frail men who are predisposed to falls and men with pelvic floor dysfunction.

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“… 20 Analysis of a single cross-sectional image from CT or magnetic resonance imaging (MRI) provides an accurate estimate of total body FFM and FM, as well as visceral FM and subcutaneous FM. 21 , 22 , 23 , 24 We have validated this technique in patients with Crohn's disease, 25 with high degrees of correlation between CT or MRI and DXA.…”

Section: Introductionmentioning

confidence: 97%

Weight and Body Composition Compartments do Not Predict Therapeutic Thiopurine Metabolite Levels in Inflammatory Bowel Disease

Holt

Strauss

Moore

2016

Clinical and Translational Gastroenterology

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OBJECTIVES:Thiopurine drugs are the most commonly used steroid-sparing therapies in moderate-to-severe inflammatory bowel disease (IBD). Their complex metabolism and their narrow therapeutic windows means that optimal dosing is difficult. However, weight-based dosing is the norm. Similar antimetabolites are dosed by body composition parameters. In IBD, treatment response and toxicity has been shown to correlate with thiopurine metabolite levels. We sought to determine whether weight or body composition parameters predicted therapeutic 6-thioguanine nucleotide (6TGN) or toxic 6-methylmercaptopurine (6MMP) levels.METHODS:This single-center retrospective cohort study identified 66 IBD patients who had body composition analysis and thiopurine metabolite levels tested. Statistical analysis was performed using Spearman correlation, Kruskal–Wallis, Mann–Whitney, and unpaired t tests and receiver-operator operating characteristic curves. A P value of <0.05 was considered significant.RESULTS:No correlation was identified between 6TGN and any body composition parameters, absolute drug dose or drug dose/kg of fat mass, fat-free mass (FFM), subcutaneous adipose tissue area, or visceral adipose tissue area. However, 6MMP correlated with azathioprine dose, thiopurine dose/kg of body weight, and with several body composition parameters.CONCLUSIONS:No relationship was found between therapeutic metabolite levels and weight or body composition compartments. Higher thiopurine doses, especially in relation to FFM, are associated with higher levels of potentially hepatotoxic 6MMP and shunting toward this metabolite. Conventional weight-based dosing to attain therapeutic metabolite levels appears unreliable and may be replaced by metabolite level testing.

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Estimating dual-energy X-ray absorptiometry-derived total body skeletal muscle mass using single-slice abdominal magnetic resonance imaging in obese subjects with and without diabetes: a pilot study

Cited by 17 publications

References 26 publications

CT Measures of Bone Mineral Density and Muscle Mass Can Be Used to Predict Noncancer Death in Men with Prostate Cancer

CT Measures of Bone Mineral Density and Muscle Mass Can Be Used to Predict Noncancer Death in Men with Prostate Cancer

Muscles of the trunk and pelvis are responsive to testosterone administration: data from testosterone dose–response study in young healthy men

Weight and Body Composition Compartments do Not Predict Therapeutic Thiopurine Metabolite Levels in Inflammatory Bowel Disease

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