Estimating Exercise-Induced Changes in Human Neuronal Networks

Türker, Kemal S.

doi:10.1249/jes.0000000000000255

Cited by 4 publications

(3 citation statements)

References 69 publications

(113 reference statements)

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“…The neural control mechanisms responsible for the modulation of motor unit discharge rate at different muscle–tendon lengths is not fully understood. Cortical and subcortical drives (Glover and Baker 2020 ; Türker 2021 ) are likely responsible for the adjustments in the neural drive to the tibialis anterior muscle as a function of its length-dependent variations in contractile properties during submaximal isometric contractions. However, peripheral afferent receptors may likely also play an important role in modulating the neural drive to muscle during force variations at different muscle–tendon lengths.…”

Section: Discussionmentioning

confidence: 99%

The force-generation capacity of the tibialis anterior muscle at different muscle–tendon lengths depends on its motor unit contractile properties

et al. 2021

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Purpose Muscle–tendon length can influence central and peripheral motor unit (MU) characteristics, but their interplay is unknown. This study aims to explain the effect of muscle length on MU firing and contractile properties by applying deconvolution of high-density surface EMG (HDEMG), and torque signals on the same MUs followed at different lengths during voluntary contractions. Methods Fourteen participants performed isometric ankle dorsiflexion at 10% and 20% of the maximal voluntary torque (MVC) at short, optimal, and long muscle lengths (90°, 110°, and 130° ankle angles, respectively). HDEMG signals were recorded from the tibialis anterior, and MUs were tracked by cross-correlation of MU action potentials across ankle angles and torques. Torque twitch profiles were estimated using model-based deconvolution of the torque signal based on composite MU spike trains. Results Mean discharge rate of matched motor units was similar across all muscle lengths (P = 0.975). Interestingly, the increase in mean discharge rate of MUs matched from 10 to 20% MVC force levels at the same ankle angle was smaller at 110° compared with the other two ankle positions (P = 0.003), and the phenomenon was explained by a greater increase in twitch torque at 110° compared to the shortened and lengthened positions (P = 0.002). This result was confirmed by the deconvolution of electrically evoked contractions at different stimulation frequencies and muscle–tendon lengths. Conclusion Higher variations in MU twitch torque at optimal muscle lengths likely explain the greater force-generation capacity of muscles in this position.

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Section: Discussionmentioning

confidence: 99%

The force-generation capacity of the tibialis anterior muscle at different muscle–tendon lengths depends on its motor unit contractile properties

et al. 2021

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Section: Introductionmentioning

confidence: 99%

“…Numerous studies have found that aerobic exercise can improve brain health and delay brain aging through mechanisms, such as strengthening neuronal connectivity, increasing neurotrophin synthesis and release, and promoting neural regeneration and synaptic reshaping. 12 Thus, aerobic exercise can serve a nonpharmacological intervention for brain aging. However, whether aerobic exercise decreases aging-induced neuronal apoptosis, especially by mediating hippocampal DAPK1 expression whereby affecting cognitive function, remains unknown.…”

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confidence: 99%

Aerobic exercise mitigates hippocampal neuronal apoptosis by regulating DAPK1/CDKN2A/REDD1/FoXO1/FasL signaling pathway in D‐galactose‐induced aging mice

Liu,

Guo,

Hong

2023

The FASEB Journal

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Brain aging is the most important risk factor for neurodegenerative disorders, and abnormal apoptosis is linked to neuronal dysfunction. Specifically, studies have found that exercise effectively inhibits hippocampal neuronal apoptosis, while the molecular mechanism remains unclear. In the present study, we investigated the impact of aerobic exercise on hippocampal neuronal apoptosis in aging mice and the potential involvement of DAPK1 and its downstream pathways based on recent data that DAPK1 may be associated with neuronal death in neurodegenerative diseases. Senescent mice were subjected to 8 weeks of Aerobic training. Following behavioral testing, hippocampal samples were examined histologically and biochemically to detect pathological changes, neuronal apoptosis, and mRNA and protein levels. We found that the exercise intervention improved spatial memory and alleviated neuronal apoptosis in the brain. Notably, exercise down‐regulated DAPK1 expression and inhibited Fas death receptor transactivation and the mitochondrial apoptotic pathway in the hippocampus. These results shed new light on the protective effect of regular exercise against brain aging though modulating the DAPK1 pathway.

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A comparison of electromyography techniques: surface versus intramuscular recording

Karacan,

Türker

2024

Eur J Appl Physiol

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Estimating Exercise-Induced Changes in Human Neuronal Networks

Cited by 4 publications

References 69 publications

The force-generation capacity of the tibialis anterior muscle at different muscle–tendon lengths depends on its motor unit contractile properties

The force-generation capacity of the tibialis anterior muscle at different muscle–tendon lengths depends on its motor unit contractile properties

Aerobic exercise mitigates hippocampal neuronal apoptosis by regulating DAPK1/CDKN2A/REDD1/FoXO1/FasL signaling pathway in D‐galactose‐induced aging mice

A comparison of electromyography techniques: surface versus intramuscular recording

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