Estimating Glomerular Filtration Rate in African American Individuals

Delanaye, Pierre; Pottel, Hans

doi:10.1001/jamainternmed.2020.2352

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…The correction for this gender difference is mainly done at the creatinine level in the CKD-EPI-equation, not at the GFR-level [8]. To our opinion, if a correction for race is required, it should also be at the creatinine level, not at the GFR-level [44,45]. Indeed, the race coefficient could then be explained by a different association between GFR and SCr.…”

Section: Possible Solutionsmentioning

confidence: 98%

“…Bhuvanakrishna et al compared measured GFR of 395 white living kidney donors with 60 Afro-Caribbean donors, living in the UK and found no difference [43]. These limited data suggest that measured GFR is not different in black and white people and that the correction of the equation at the GFR level in the MDRD and CKD-EPI-equations is misleading [44,45]. A parallelism can be made with sex.…”

Section: Possible Solutionsmentioning

confidence: 99%

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The « race » correction in estimating glomerular filtration rate: an European point of view

Delanaye

Mariat

Glassock

et al. 2021

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of review There is currently a heated debate ongoing whether or not to use the race coefficient for black people in the Modification of Diet in Renal Diseases and Chronic Kidney Disease Epidemiology-equation. The use of the race coefficient is thought by several American authors as a source of discrimination. Recent findings It has recently been shown that the race coefficient is inaccurate in European and African black people. Therefore, it seems that the race correction is more a correction for black Americans, rather than for black in general. This ‘correction’ at the glomerular filtration rate (GFR)-level has been criticized, as it is misleading, and should be abandoned, as it has not been shown that GFR is different between black and white people. However, as differences in creatinine generation between black and white people might exist, a correction or adjustment, different for black and white people, at the creatinine level might be required, very similar to the different scaling of creatinine for males and females. Summary The current debate on the race coefficient is particularly difficult because of the absence of good scientific data in black subjects and there lies the real discrimination in our opinion. We therefore call for future dedicated studies, both in Europe and USA.

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Section: Possible Solutionsmentioning

confidence: 98%

Section: Possible Solutionsmentioning

confidence: 99%

The « race » correction in estimating glomerular filtration rate: an European point of view

Delanaye

Mariat

Glassock

et al. 2021

Current Opinion in Nephrology &Amp; Hypertension

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“…Once again, the assertion that race or ethnicity (or still worse skin color) is influencing serum creatinine is a scientific “oversimplification.” Second, there are still variations in serum creatinine between populations, and ignoring these differences in eGFR equations can only lead to bias [38, 41, 42]. Third, if a correction should be applied to creatinine-based equations, it should definitively be at the creatinine level, not at the GFR level [43, 44]. If we have demonstrated that there are differences in serum creatinine concentration between populations, two unresolved issues remain.…”

Section: What Glomerular Filtration Rate Estimation Is (And What It I...mentioning

confidence: 99%

Glomerular Filtration Rate Estimation in Adults: Myths and Promises

Delanaye,

Cavalier,

Stehlé

et al. 2024

Nephron

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Background: In daily practice, glomerular filtration rate (GFR) is estimated with equations including renal biomarkers. Among these biomarkers, serum creatinine remains the most used. However, there are many limitations with serum creatinine we will discuss in the current review. We will also discuss how creatinine-based equations have been developed and what we can expect from them in terms of performance to estimate GFR. Summary: Different creatinine-based equations have been proposed. We will show the advantages of the recent European Kidney Function Consortium (EKFC) equation. This equation can be used in children and adults. This equation can also be used with some flexibility in different populations. Key messages: GFR is estimated by creatinine-based equations, but the most important for nephrologists is probably to know the limitations of these equations.

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“…The practice of using a multiplier to calculate GFR for Black individuals has come under scrutiny in recent years not only in part because of concerns about the effects of the use of race in medical decision making 3 but also because of questions about the scientific basis of this 33 . A lower correction factor was found in European Blacks 34 .…”

Section: Glomerular Filtration Rate and Racementioning

confidence: 99%