Estimating nicotine consumption in eight cities using sewage epidemiology based on ammonia nitrogen equivalent population

Zheng, Qiuda; Lin, Johnson; Pei, Wei; Guo, Mingxia; Wang, Zhuang; Wang, Degao

doi:10.1016/j.scitotenv.2017.02.214

Cited by 81 publications

(35 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies, however, have concluded that use of such nutrients is appropriate (e.g. Choi et al 2018, Been et al 2014), and Zheng et al (2017 found population estimates based on ammonia-nitrogen to show good agreement with estimates provided by wastewater treatment plant operators with local knowledge. Furthermore, given that the focus of this study is a near-to-source site, and it is known with a high degree of certainty that there are no industrial inputs to the wastewater, these concerns are not considered a barrier in this study.…”

Section: = ( )mentioning

confidence: 97%

Building knowledge of university campus population dynamics to enhance near-to-source sewage surveillance for SARS-CoV-2 detection

Sweetapple

Melville‐Shreeve

Chen

et al. 2021

Preprint

View full text Add to dashboard Cite

Wastewater surveillance has been widely implemented for monitoring of SARS-CoV-2 during the global COVID-19 pandemic, and near-to-source monitoring is of particular interest for outbreak management in discrete populations. However, variation in population size poses a challenge to the triggering of public health interventions using wastewater SARS-CoV-2 concentrations. This is especially important for near-to-source sites that are subject to significant daily variability in upstream populations. Focusing on a university campus in England, this study investigates methods to account for variation in upstream populations at a site with highly transient footfall and provides a better understanding of the impact of variable populations on the SARS-CoV-2 trends provided by wastewater-based epidemiology. The potential for complementary data to help direct response activities within the near-to-source population is also explored, and potential concerns arising due to the presence of heavily diluted samples during wet weather are addressed. Using wastewater biomarkers, it is demonstrated that population normalisation can reveal significant differences between days where SARS-CoV-2 concentrations are very similar. Confidence in the trends identified is strongest when samples are collected during dry weather periods; however, wet weather samples can still provide valuable information. It is also shown that building-level occupancy estimates based on complementary data aid identification of potential sources of SARS-CoV-2 and can enable targeted actions to be taken to identify and manage potential sources of pathogen transmission in localised communities.

show abstract

Section: = ( )mentioning

confidence: 97%

Building knowledge of university campus population dynamics to enhance near-to-source sewage surveillance for SARS-CoV-2 detection

Sweetapple

Melville‐Shreeve

Chen

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…In addition, sewage testing allows us to estimate uses of other detectable substances/their metabolites for general public health assessments. Urological waste water testing has been used to assess the use of depressants as well as antidepressants [33], nicotine (as a proxy for smoking) [34,35], alcohol [35], and select diseases such as gout [36]. It has been used to determine the usage of a range of medication [37], such as antibiotics [38], and decongestants [38], as well medication for other disorders such as ADHD (e.g., Ritalin) [39], Urological waste water testing allowed health authorities to assess the uptake of antiviral treatments (e.g., Tamilflu) during H1N1 influenza pandemics [38,40].…”

Section: Testing Sewage For the Detection Of Drugs And Pathogensmentioning

confidence: 99%

Preparing for COVID-2x: Urban Planning Needs to Regard Urological Wastewater as an Invaluable Communal Public Health Asset and Not as a Burden

Spennemann

2021

Urban Science

View full text Add to dashboard Cite

Prior to the COVID-19 pandemic, the analysis of urological wastewater had been a matter of academic curiosity and community-wide big-picture studies looking at drug use or the presence of select viruses such as Hepatitis. The COVID-19 pandemic saw systematic testing of urological wastewater emerge as a significant early detection tool for the presence of SARS-CoV-2 in a community. Even though the pandemic still rages in all continents, it is time to consider the post-pandemic world. This paper posits that urban planners should treat urological wastewater as a communal public health asset and that future sewer design should allow for stratified multi-order sampling.

show abstract

“…The aspect of BioSCIM and sewage epidemiology that has attracted the most attention is the need to estimate small-area population size via the use of either chemical markers or biomarkers. New studies on this aspect are limited (i.e., Castiglioni et al, 2013 ; Chen et al, 2014 ; Gao et al, 2016 ; González-Mariño et al, 2017 ; Lai et al, 2015 ; Nakada et al, 2017 ; O’Brien et al, 2017 ; O’Brien et al, 2014 ; Rico et al, 2017 ; Senta et al, 2015 ; Thai et al, 2014 ; Zheng et al, 2017 ); note, however, that non-chemical-based approaches are also being explored (e.g., Thomas et al, 2017 ). This is important because the overall levels of markers in sewage often must be normalized, and calculation of per capita contributions is one widely accepted approach.…”

Section: Update On Published Advancements Relevant To Bioscimmentioning

confidence: 99%

“…The second is to normalize against a proxy for de facto population size; a suitable proxy might be a marker or group of markers that reflect per capita contributions. These are the two approaches that have been used in conventional sewage epidemiology—particularly for calculating average per capita consumption of drugs (e.g., Lai et al, 2015 ; Rico et al, 2017 ; Zheng et al, 2017 ).…”

Section: Factors Complicating Measurement Of Biomarkers In Sewagementioning

confidence: 99%

Monitoring wastewater for assessing community health: Sewage Chemical-Information Mining (SCIM)

Daughton

2018

Science of The Total Environment

162

118

View full text Add to dashboard Cite

Timely assessment of the aggregate health of small-area human populations is essential for guiding the optimal investment of resources needed for preventing, avoiding, controlling, or mitigating human exposure risks, as well as for maintaining or promoting health. Seeking those interventions yielding the greatest benefit with respect to the allocation of resources is critical for making progress toward community sustainability, reducing health disparities, promoting social justice, and maintaining or improving collective health and well-being. More informative, faster, and less-costly approaches are needed for guiding investigation of cause-effect linkages involving communities and stressors originating from both the built and natural environments. One such emerging approach involves the continuous monitoring of sewage for chemicals that serve as indicators of the collective status of human health (or stress/disease) or any other facet relevant to gauging time-trends in community-wide health. This nascent approach can be referred to as Sewage Chemical-Information Mining (SCIM) and involves the monitoring of sewage for the information that resides in the form of natural and anthropogenic chemicals that enter sewers as a result of the everyday actions, activities, and behaviors of humans. Of particular interest is a specific embodiment of SCIM that would entail the targeted monitoring of a broad suite of endogenous biomarkers of key physiologic processes (as opposed to xenobiotics or their metabolites). This application is termed BioSCIM—an approach roughly analogous to a hypothetical community-wide collective clinical urinalysis, or to a hypothetical en masse human biomonitoring program. BioSCIM would be used for gauging the status or time-trends in community-wide health on a continuous basis. This paper presents an update on the progress made with the development of the BioSCIM concept in the period of time since its original publication in 2012, as well as the next steps required for its continued development.

show abstract

Estimating nicotine consumption in eight cities using sewage epidemiology based on ammonia nitrogen equivalent population

Cited by 81 publications

References 37 publications

Building knowledge of university campus population dynamics to enhance near-to-source sewage surveillance for SARS-CoV-2 detection

Building knowledge of university campus population dynamics to enhance near-to-source sewage surveillance for SARS-CoV-2 detection

Preparing for COVID-2x: Urban Planning Needs to Regard Urological Wastewater as an Invaluable Communal Public Health Asset and Not as a Burden

Monitoring wastewater for assessing community health: Sewage Chemical-Information Mining (SCIM)

Contact Info

Product

Resources

About