Estimating occupational exposure to carcinogens in Quebec

Duguay, Patrice; Ostiguy, Claude; Boucher, Alexandre; Roberge, Brigitte; Peters, Cheryl; Demers, Paul A.

doi:10.1002/ajim.22200

Cited by 15 publications

(17 citation statements)

References 23 publications

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“…Dust generated in wood processing is one of the most common occupational and carcinogenic agents identified to date. The manipulation of wood can create fine and abundant dust with sanding, and thicker dust with milling or cutting [ 1 , 2 , 3 ]. The location and accumulation of particles has been found to depend on the size, shape, and density of the air flow available.…”

Section: Introductionmentioning

confidence: 99%

Association between Occupational Exposure to Wood Dust and Cancer: A Systematic Review and Meta-Analysis

et al. 2015

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ObjectiveTo perform a systematic review to analyze the association between occupational exposure to wood dust and cancer.MethodsA systematic literature search of entries made in the MEDLINE-PubMed database between 1957 and 2013 was conducted to identify studies that had assessed the relationship between occupational exposure to wood dust and different types of cancer. A meta-analysis of selected case-control and cohort studies was subsequently performed.ResultsA total of 114 studies were identified and 70 were selected for review. Of these, 42 studies focused on the relationship between wood dust and nasal cancer (n = 22), lung cancer (n = 11), and other types of cancer (n = 9). Low-to-moderate quality evidence that wood dust acts as a carcinogen was obtained, and a stronger association between wood dust and nasal adenocarcinoma was observed. A lesser association between wood dust exposure and lung cancer was also observed. Several studies suggested that there is a relationship between wood dust and the onset of other cancers, although there was no evidence to establish an association. A meta-analysis that included four case-controls studies showed that workers exposed to wood dust exhibited higher rates of nasal adenocarcinoma than other workers (odds ratio = 10.28; 95% confidence interval: 5.92 and 17.85; P<0,0001), although a large degree of heterogeneity was found.ConclusionsLow-to-moderate quality evidence supports a causal association between cancer and occupational exposure to wood dust, and this association was stronger for nasal adenocarcinoma than for lung cancer. There was no evidence of an association between wood dust exposure and the other cancers examined.

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Section: Introductionmentioning

confidence: 99%

Association between Occupational Exposure to Wood Dust and Cancer: A Systematic Review and Meta-Analysis

et al. 2015

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“…Identifying the number and type of carcinogens that ethnic minority workers are exposed to will enable targeting of interventions to reduce these exposures, which in turn may result in lower numbers of occupational cancers in the future. Several studies have estimated the prevalence and/or cancer burden of occupational carcinogens in a range of countries [Kauppinen et al, ; Partanen et al, ; Guignon and Sandret, ; Mirabelli and Kauppinen, ; Blanco‐Romero et al, ; Rushton et al, ; Carey et al, ; Labrèche et al, ]. For example, a recent study estimated that 40% of workers in Australia are exposed to carcinogens at work [Carey et al, ], while a study from Great Britain estimated that 5.3% of all cancer deaths in Great Britain in 2005 were attributable to occupation [Rushton et al, ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of occupational exposure to carcinogens among workers of Arabic, Chinese and Vietnamese ancestry in Australia

Boyle

Carey

Glass

et al. 2015

American J Industrial Med

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“…Despite a general lack of consensus or gold standard method to undertake prioritization exercises in occupational cancer prevention, some exercises have been applied to identify and estimate exposure to occupational carcinogens. Estimates of occupational exposure to carcinogens were calculated in Quebec, Canada to inform provincial research and intervention priorities (these estimates were partly based on CAREX Canada data and methods) [26] . The selection of carcinogens for these intervention priorities was based on provincial occupational health regulations and IARC classifications and was largely dictated by the availability of data.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it is very difficult to conceptualize a prioritization exercise that is specific to any one context (i.e., occupational carcinogen exposures) without relying on some kind of expert judgment. Indeed, in all of the previous occupational health priority setting exercises that were located, some degree of reliance on expert judgment (sometimes in combination with input from other groups and stakeholders) was used [2] , [5] , [6] , [7] , [26] , [28] , [29] , [30] . Priorities are not always numbers that can simply be looked up, nor should they be; including a qualitative assessment allows for a better understanding of local contexts and exposure circumstances that impact priority setting and the feasibility of future preventative actions.…”

Section: Discussionmentioning

confidence: 99%

Priority Setting for Occupational Cancer Prevention

Peters

Palmer

Telfer

et al. 2018

Safety and Health at Work

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BackgroundSelecting priority occupational carcinogens is important for cancer prevention efforts; however, standardized selection methods are not available. The objective of this paper was to describe the methods used by CAREX Canada in 2015 to establish priorities for preventing occupational cancer, with a focus on exposure estimation and descriptive profiles.MethodsFour criteria were used in an expert assessment process to guide carcinogen prioritization: (1) the likelihood of presence and/or use in Canadian workplaces; (2) toxicity of the substance (strength of evidence for carcinogenicity and other health effects); (3) feasibility of producing a carcinogen profile and/or an occupational estimate; and (4) special interest from the public/scientific community. Carcinogens were ranked as high, medium or low priority based on specific conditions regarding these criteria, and stakeholder input was incorporated. Priorities were set separately for the creation of new carcinogen profiles and for new occupational exposure estimates.ResultsOverall, 246 agents were reviewed for inclusion in the occupational priorities list. For carcinogen profile generation, 103 were prioritized (11 high, 33 medium, and 59 low priority), and 36 carcinogens were deemed priorities for occupational exposure estimation (13 high, 17 medium, and 6 low priority).ConclusionPrioritizing and ranking occupational carcinogens is required for a variety of purposes, including research, resource allocation at different jurisdictional levels, calculations of occupational cancer burden, and planning of CAREX-type projects in different countries. This paper outlines how this process was achieved in Canada; this may provide a model for other countries and jurisdictions as a part of occupational cancer prevention efforts.

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Estimating occupational exposure to carcinogens in Quebec

Abstract: Although crude, estimates obtained with different data sources allow identification of research and intervention priorities for cancer in Quebec.

Cited by 15 publications

References 23 publications

Association between Occupational Exposure to Wood Dust and Cancer: A Systematic Review and Meta-Analysis

Association between Occupational Exposure to Wood Dust and Cancer: A Systematic Review and Meta-Analysis

Prevalence of occupational exposure to carcinogens among workers of Arabic, Chinese and Vietnamese ancestry in Australia

Priority Setting for Occupational Cancer Prevention

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