Abstract:The genetic basis of phenotypic variation across populations has not been well explained for most traits. Several factors may cause disparities, from variation in environments to divergent population genetic structure. We hypothesized that a population level polygenic risk score (PRS) can explain phenotypic variation among geographic populations based solely on risk allele frequencies. We applied a population specific PRS (psPRS) to 26 populations from the 1000 Genomes to four phenotypes: lactase persistence (… Show more
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