The objective of this study was to estimate the burden of morbidity and mortality of Covid-19 in Maranhão over a 24-month period, between the years 2020 and 2022. For this purpose, the data used were obtained from the bulletins of the State Department of Health of Maranhão, the IBGE portal, and the 2019 Global Burden of Disease Study. Using this information (confirmed cases and deaths, life expectancy, and disability weights), the average fatality rate and DALYs for the period were estimated. In the calculation of YLLs, two age distributions were used: 10-year age groups and individual ages. An average fatality rate of 2.58% (3.51% for men and 1.86% for women) and a mortality rate of 0.15% (151.73 deaths per 100,000 inhabitants) were observed. According to IBGE, life expectancy in Maranhão in 2021 was 68 years for men and 76 for women. Based on this, an estimate of 95,206 YLLs and 938.377539 YLDs was obtained, totaling 96,144.377 DALYs for the period or 1,344 DALYs per 100,000 inhabitants. Thus, it can be concluded that these results place Covid-19 at a very high level of morbidity and mortality, surpassing the DALYs recorded for all lower respiratory diseases in Maranhão in 2018 and 2019. These values make studies on the burden of Covid-19 in the region important efforts in understanding the damage caused by this disease.