“…We were able to demonstrate a statistically significant correlation of the observed adverse effect of hypoxia and the symptom of fatigue with p < 0.05 in the quantitative evaluation of the primary studies. Our review of the literature shows that both healthy and sick people can experience Mask-Induced Exhaustion Syndrome (MIES), with typical changes and symptoms that are often observed in combination, such as an increase in breathing dead space volume [22,24,58,59], increase in breathing resistance [31,35,60,61], increase in blood carbon dioxide [13,15,17,19,[21][22][23][24][25][26][27][28][29][30]35], decrease in blood oxygen saturation [18,19,21,23,[28][29][30][31][32][33][34], increase in heart rate [23,29,30,35], increase in blood pressure [25,35], decrease in cardiopulmonary capacity [31], increase in respiratory rate [15,21,23,…”