Estimating the economic consequences of an increased medication adherence due to a potential improvement in the inhaler technique with Spiromax^®compared with Turbuhaler^®in patients with moderate-to-severe chronic obstructive pulmonary disease in Spain

Abstract

ObjectiveThe objective of this study was to estimate the economic impact of the introduction of DuoResp® Spiromax®, budesonide/formoterol fixed-dose combination (FDC), focusing on an increase in medication adherence due to an enhancement of the inhalation technique for the treatment of COPD patients in Spain and 5 regions including Andalusia, Catalonia, Galicia, Madrid, and Valencia.MethodsA 4-year budget impact model was developed for the time period of 2015–2018. This study aimed at evaluating the budget impact associated with the introduction of DuoResp Spiromax in comparison with Symbicort® Turbuhaler® and Rilast® Turbuhaler. National and regional data on COPD prevalence were obtained from the literature. Input data on health care resource utilization were obtained by clinical consultation. Resource included primary care visits, specialist visits, hospitalization, and emergency room visits as well as the length of hospital stay. Based on both pharmacological and health care resource costs, overall annual treatment cost per patient was estimated in EUR 2015.ResultsIt was calculated that 130,777 adults were treated with budesonide/formoterol FDC delivered by a dry powder inhaler, Turbuhaler, in Spain in 2015. However, the target population decreases over the next 4 years. This pattern was observed in 4 regions, but for Andalusia, the treated population increased slightly. The overall budget savings in Spain with the market share of DuoResp Spiromax were estimated to be €6.01 million for the time period of 2015–2018. Region-specific data resulted in savings of €902,133 in Andalusia, €740,520 in Catalonia, €464,281 in Galicia, €748,996 in Madrid, and €495,812 in Valencia for the time period of 2015–2018.ConclusionThe introduction of budesonide/formoterol FDC delivered by Spiromax for COPD treatment is likely to contribute in a reduction of health care costs for Spain and in 5 Spanish regions. This model forecasts that Spain and these 5 Spanish regions were likely to have savings, which might be due to fewer days of hospitalization, avoided emergency room, and primary care visits.

<p>Estimation of the Clinical and Economic Impact of an Improvement in Adherence Based on the Use of Once-Daily Single-Inhaler Triple Therapy in Patients with COPD</p>

“…Overall, the total budget savings for Spain was expected to be €6.01 million over the following 4 years. 45 The previously described Farmaindustria model, on which the current analysis was based, estimated savings of €8.5 million with an increase of 1% in the proportion of adherent patients. 23…”

“…In Spain, the relationship between treatment adherence in COPD and costs and clinical outcomes was estimated in two economic analyses. Darbà et al 45 estimated the economic impact of the introduction of a budesonide/formoterol fixed-dose combination for the treatment of patients with COPD, focusing on an increase in medication adherence due to enhancement of the inhalation technique. Overall, the total budget savings for Spain was expected to be €6.01 million over the following 4 years.…”