“…After removal of duplicates, 12 392 unique citations were screened by title and abstract, and 65 full texts were sourced. Of these, 41 EPOC studies 16 , 17 , 18 , 19 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 and three non-EPOC studies 65 , 66 , 67 fit the inclusion criteria ( figure 1 ; appendix, pp 6, 7 ). The EPOC studies included data from more than 57 million births, and from 4·6 million GP diagnoses and 2·7 million hospital admissions for respiratory conditions.…”